Heart Disease Weekly
Susan Hasty, Publisher
Table of Contents . . . April 11th, 2006
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Heart Disease Weekly | Other Publications
Angiology - G protein-dependent regulation of endothelial NO synthase expression is a novel mechanism
Angiology - Wall shear stress implications in atherosclerosis are verified by hemodynamic analysis
Coronary Artery Disease - Trial shows varied stenting methods can be effective in treating complex artery disease
Statins - Statin anti-inflammatory properties involve peroxisome proliferator-activated receptor-alpha
Statins - Statins are suggested to have anti-arrhythmic properties
Anesthesia - Blood versus crystalloid cardioplegia shows little difference in myocardial oxygen tension
Anesthesia - Recent findings in anesthesia described
Aneurysms - Large unruptured aneurysms are benefited by treatment
Angiology - 8-iso-PGF2alpha is linked to coronary artery disease in coronary angiography patients
Angiology - Artery stiffness may be predicted by carotid-femoral pulse wave velocity and carotid stiffness
Angiology - Carotid endarterectomy is associated with transient increase in S-100B serum levels
Angiology - Effects of HDL-associated lysosphingolipids operate via Akt->NF-kappa B signaling pathways
Angiology - Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake
Angiology - Homocysteine-induced endothelin-1 release depends on hyperglycemia and reactive oxygen species
Angiology - Lectin-like oxidized LDL receptor-1 is expressed after vascular injury
Angiology - Microenvironmental determinates regulate endothelial cell ephrinB2
Angiology - Neo-aortic regurgitation progresses after arterial switch operation
Angiology - Plasma N-terminal pro-atrial natriuretic peptide is key correlate of vascular endothelial function
Angiology - Reports add new data to angiology research
Angiology - Research in angiology provides new insights
Angiology - Researchers report details of new studies and findings in the area of angiology
Angiotensin - The active losartan metabolite EXP3179 is a partial PPAR-gamma agonist
Aortic Injury - Open surgical repair is better for young patients without brain injury
Apoptosis - Schisandrin B enhanced doxorubicin-induced apoptosis of cancer cells
Atherosclerosis - Atherosclerosis, MI, and cardiac dysfunction were delayed by hepatic lipase deficiency in model
Atherosclerosis - Findings describe new data in atherosclerosis research
Atherosclerosis - PPARdelta promotes very low-density lipoprotein-derived fatty acid catabolism in macrophage
Atherosclerosis - Reports describe recent advances in atherosclerosis research
Atherosclerosis - Researchers' data advance atherosclerosis research
Atherosclerosis - Studies describe new findings in atherosclerosis research
Autoimmune Disease - Osteopontin-CD44 pathway does not participate in development of autoimmune myocarditis
Awards - Frost & Sullivan recognizes Dade Behring for excellence in customer service leadership
Biomedical Engineering - Bioengineered grafts generate angiogenesis
Blood Safety - Blood transfusions linked to increased mortality in patients suffering from cardiac episodes
Business Update - DATATRAK's ECG laboratory component of the eClinical Platform selected by Duke business unit
Business Update - Korean NIH, Affymetrix to collaborate to identify genes associated with critical diseases
Cardiac Migraine - Cardiac migraine may be a distinct entity
Cardiac Risk - Dangers of stopping clopidogrel (Plavix) reported for patients with stents, other conditions
Cardiology - ARRIVE II registry demonstrates 2.5% Taxus-related re-intervention rate in complex lesions
Cardiology - Anti-thrombotic medication reduces risk of death for heart attack patients
Cardiology - Arrhythmogenic right ventricular dysplasia histopathology varies with age - in both ventricles
Cardiology - Cardiovascular risk may be mainly associated with waist circumference in Tehranian women
Cardiology - Coronary heart disease deaths in Ireland halved in 15 years
Cardiology - ECG transmission from ambulance to hospital cuts time to treat heart attacks
Cardiology - Estrogen receptor alpha mediates potassium channel stimulation
Cardiology - Findings describe new data in cardiology research
Cardiology - First human implanted with WorldHeart's next-generation rotary VAD
Cardiology - Functional capacity may help stratify women to pharmacologic versus exercise stress testing
Cardiology - GDF15/MIC-1 functions as a protective and antihypertrophic factor
Cardiology - Many high-risk patients do not receive cholesterol-lowering therapies
Cardiology - New findings in cardiology described
Cardiology - New findings in the area of cardiology described
Cardiology - Obesity-related heart disease may be linked to plasma endothelial cell-specific molecule-1
Cardiology - Patients with angina and coronary occlusion display varying levels of angiogenic growth factor
Cardiology - Patients with subclinical hyperthyroidism show longer corrected QT intervals
Cardiology - Postural blood pressure changes and orthostatic hypotension may be traced to arterial stiffness
Cardiology - Progressive myocardial ischemia stalls upon angiogenic induction by VEGF-C
Cardiology - Recent findings illuminate research in cardiology
Cardiology - Recent studies add new data to cardiology research
Cardiology - Refinements and innovations enhance safety, effectiveness of therapies for acute coronary syndromes
Cardiology - Reports advance knowledge in cardiology research
Cardiology - Researchers develop method to identify children and teens at risk for sudden cardiac death
Cardiology - Researchers publish new studies and findings in the area of cardiology
Cardiology - Researchers' findings advance cardiology research
Cardiology - Should heart attack care be more like trauma care?
Cardiology - Vagal excitation is associated with shortening of fibrillatory cycle length in the pulmonary vein
Cardiology - Vascularized extracellular matrix replaces implanted scaffolds in injured myocardium
Cardiomyocytes - Adenylyl cyclase type V deletion reduces LV responsiveness to beta-adrenergic stimulation
Cardiomyocytes - Hypercontractile female hearts exhibit reduced ischemia/reperfusion injury
Cardiomyocytes - Role of cAMP response element binding protein in cardiovascular remodeling is focus of review
Cardiovascular Disease - After adenosine-induced cardiac arrest, changes in hemodynamic variables reversed completely
Cardiovascular Disease - Findings in cardiovascular disease provide new insights
Cardiovascular Disease - For some aortic aneurysms with distal extension, stepwise anastomosis is a secure option
Cardiovascular Disease - ISIS 301012 does not interact with currently marketed lipid-lowering drugs, study says
Cardiovascular Disease - Ischemic heart disease is associated with mental vulnerability as risk factor
Cardiovascular Disease - Managing hyperlipidemia includes new LDL-C targets for persons at high risk
Cardiovascular Disease - NHLBI Working Group on research in adult congenital heart disease issues recommendations
Cardiovascular Disease - Postoperative white blood cell count predicts atrial fibrillation after cardiac surgery
Cardiovascular Disease - Researchers detail new studies and findings in the area of cardiovascular disease
Cardiovascular Disease - Researchers report details of new studies and findings in the area of cardiovascular disease
Cardiovascular Research - Atrial fibrillation is associated with differential remodeling in myocardium
Cardiovascular Research - Cardiac Science announces new research for assessing risk of cardiovascular death
Cardiovascular Research - Cardiovascular effects of matrix metalloproteinases in murine models provide wealth of data
Cardiovascular Research - Clinical impact of bleeding measured by two classifications was compared in acute coronary syndrome
Cardiovascular Research - Data analysis shows Vytorin significantly reduced LDL cholesterol in comparison group
Cardiovascular Research - Heart attack patients do better with sirolimus-eluting stent than bare-metal stent, study says
Cardiovascular Research - High intensity statin therapy shows promise for inducing regression of coronary atherosclerosis
Cardiovascular Research - In atherosclerotic lesions of heart disease patients, diverse bacterial signatures were detected
Cardiovascular Research - Inflammatory heart disease, myocardial proteases, and matrix remodeling are focus of review
Cardiovascular Research - Ischemic preconditioning causes biphasic pattern of ST elevation during repeat coronary occlusions
Cardiovascular Research - Use of cardiac resynchronization devices during hospital stays linked to better outcomes
Cardiovascular Risk Factors - Coronary heart disease risk is associated with plasma homocysteine thiolactone adducts
Clinical Trials - Alexion updates phase III results for PRIMO-CABG2 study
Clinical Trials - Arixtra reduced risk of death or recurrent heart attack in patients with acute coronary syndromes
Clinical Trials - Atherosclerotic events are reduced as effectively by angiotensin receptor blockers as ACE inhibitors
Clinical Trials - Critical Therapeutics announces decision to discontinue clinical trial of CTI-01
Clinical Trials - Eisai reports results from latest Donepezil study in vascular dementia
Clinical Trials - Excellent in-stent restenosis clinical trial results reported for TAXUS Stent System
Clinical Trials - Phase 2 efficacy study in patients with acute decompensated heart failure initiated
Clinical Trials - Role of angiotensin II receptor blocker therapy is focus of review
Clinical Trials - Tenecteplase-facilitated PCI was associated with more major adverse events than PCI alone
Clinical Trials - X-Cell Medical initiates enrollment for clinical trial of estradiol eluting stent
Collaborations - Medeikon and American Cardiovascular Research Institute collaborate on cardiac disease technology
Complementary & Alternative Medicine - Study shows complementary alternative medicine reduces pain and tension in heart surgery patients
Coronary Artery Bypass - No relation seen between volume and outcome of off-pump coronary artery bypass
Dental Research - Earlier periodontal treatment leads to lower medical costs
Depression - Link between depression and medication nonadherence should be considered in cardiovascular care
Developmental Biology - Myocardial wall rotation of the outflow tract is implicated in positioning of great arteries
Diabetes Complications - Aspirin can inhibit platelet aggregation in most patients with diabetes
Diabetes Complications - EDHF-mediated and endothelium-independent relaxations are impaired in diabetic rat arteries
Diabetes Complications - Glucagon-like peptide 1 administration may reduce cardiovascular risk in type 2 diabetes
Diabetes Complications - Glycoxidation of LDL promotes apoptotic pathways and NFkappaB activation in coronary cells
Diabetes Complications - Nai + increase influences ischemia susceptibility in hearts from diabetic mice
Diabetes Diagnosis - Primary care practices may improve undiagnosed diabetes detection and improve 1-year outcomes
Diabetes Pathogenesis - Baroreflex gain are progressively reduced with increasing severity of insulin resistance
Diabetes Pathogenesis - RAS and NOS3 polymorphisms do not seem to influence cardiovascular disease in diabetics
Diabetes Pathogenesis - Tissue degeneration in hearts could be caused by increased cell-cycle arrest and DNA repair
Diabetes Therapy - Lisinopril plus telmisartan may prevent diabetic nephropathy type 2 diabetes, hypertension
Diabetes Therapy - NCX4016 has protective effect against ischemia-reperfusion injury in diabetic rat hearts
Diabetes Therapy - Restenosis in diabetics with coronary lesions was reduced by radiation after stent implant
Diagnostics - Cardiovascular mortality is predicted by ambulatory arterial stiffness index
Diagnostics - New findings in the area of diagnostics detailed
Diagnostics - Reports add new data to diagnostics research
Diagnostics - Researchers detail new studies and findings in the area of diagnostics
Diet & Nutrition - Aortic valve disease induced by high fat/high carbohydrate diet in C57BL/6J mice
Diet & Nutrition - Appropriate nutrition is an important component of healthy aging
Diet & Nutrition - Genetic interactions with diet influence the risk of cardiovascular disease
Diet & Nutrition - Leptin appears to raise renal sympathetic nerve activity and BP after chronic high-fat diet
Drug Delivery - Scientists use wireless MicroChips to control drug release over time
Drug Development - Adenosine kinase is a novel target for protecting tissues against ischemia
Drug Development - Ambrisentan receives U.S. FDA fast track designation for PAH development
Drug Development - Glibenclamide in single oral dose does not reduce pain-free or maximal walking distance
Drug Resistance - Methicillin-resistant Staphylococcus is linked to in-hospital mortality in cardiac surgical patients
Drug Toxicity - Education on NSAIDs and aspirin-associated toxicity for primary care physicians is warranted
End-of-Life Issues - Living fully with end-stage heart failure includes attending to four types of tasks
Endocrinology - Fat distribution pattern and coronary risk profile linked to X chromosome
Endocrinology - Recombinant human growth hormone affects metabolic parameters and atherosclerotic markers
Environmental Health Risk - Atrazine monitoring reveals the effectiveness of Abraxis ELISA method may be limited
Finance - DeCODE genetics reports 2005 revenues of $44 million, up from $42.1 million for 2004
Finance - Egalet a/s secures US$27.6 million via financing co-led by Atlas Venture and Index Ventures
Finance - Medical device company TransMedics, Inc. raises $29.75 million in series C funding
Finance - Mera Pharmaceuticals announces first quarter revenue of $152,394
Fitness & Wellness - Exercise raises VEGF receptor levels in study volunteers
Gene Therapy - Uronic acid functionalized copolymers can be synthetic gene carriers
Gene Therapy - Viral vectors activate endothelial cell signal transduction
Genetics & Genomics - Influence of matrix metalloproteinase genotype on cardiovascular disease is focus of review
Genetics & Genomics - New findings in the area of genetics & genomics described
Geriatrics - Cardiovascular gene expression shifts with advancing age
Heart Disease - Recent findings in heart disease provide new insights
Heart Failure - Advanced heart failure is independent predictor of inappropriate ICD shocks
Heart Failure - African American heart failure trial shows women, men both benefit from BiDil
Heart Failure - Biventricular pacing may be beneficial over univentricular pacing for resynchronization patients
Heart Failure - Coreg at hospital discharge associated with improved survival in heart failure
Heart Failure - Gene variations may determine which heart failure patients will benefit from BiDil
Heart Failure - Heart failure functional class and prognosis correlate with Doppler measures
Heart Failure - Heart failure severity linked to increased prevalence of sleep-related breathing disorders
Heart Failure - In mild, stable heart failure, metoprolol increases plasma B-type natriuretic peptides
Heart Failure - Leptin modulates cell size, MMP-2 expression, and collagen profile in human cardiomyocytes
Heart Failure - Pathways of matrix metalloproteinase induction in heart failure are focus of review
Heart Failure - Treatment of anemia with Aranesp may provide clinical benefits in heart failure patients
Hematology - Hemorrhage risk among patients with warfarin-associated coagulopathy is low
Hematology - Immobilized thrombin facilitates platelet adhesion and aggregation
Hepatitis C Virus - Studies advance knowledge in hepatitis C virus research
High Cholesterol - Torcetrapib/atorvastatin research further supports raising good and lowering bad cholesterol
Hypertension - Coreg CR new drug application as blood pressure therapy accepted for review by U.S. FDA
Hypertension - High prevalence of hypertension is found with in-hospital 24-h blood pressure measurement
Hypertension - Hypertension and cardiovascular disease risk are linked to age, diabetes, and albuminuria
Hypertension - Hypertension may be adversely affected by swimming therapy in older women
Hypertension - Hypertension may be linked to ethnicity-specific regulator of G-protein signaling
Hypertension - In hypertension, ACE inhibition modulates vascular smooth muscle activation, wall remodeling
Hypertension - In hypertensive families, acute exercise reduces vascular reactivity to mental challenge
Hypertension - In idiopathic pulmonary arterial hypertension, arterial capacitance is predictor of mortality
Hypertension - In prehypertensives, impaired glucose tolerance raised cardiovascular disease risk
Hypertension - Initial studies show Aliskiren effective as hypertension drug
Hypertension - New data illuminates research in hypertension
Hypertension - Recent findings in hypertension provide new insights
Hypertension - Reports add new data to hypertension research
Hypertension - Researchers provide details of new studies and findings in the area of hypertension
Hypertension - Resting blood pressure reflects varied cardiovascular, sympathetic responses to mental stress
Hypotension - Clinical response to BiDil evaluated by baseline blood pressure
Hypoxia - Recent studies add new data to hypoxia research
Imaging - Dobutamine stress echocardiography sensitivity improves after beta blockade
Imaging - New data illuminates research in imaging
Imaging - Optical coherence tomography is promising for imaging coronary atherosclerotic plaque
Imaging - Pre-op MRI predicts left ventricular function after drug-eluting stent implantation
Imaging - Reports describe recent advances in imaging research
Imaging - Speckle tracking echocardiography enables angle-independent measures of left ventricular strains
Imaging - Stress ECG, heart rate response to dobutamine should be included in image interpretation
Imaging - Studies advance knowledge in imaging research
Imaging - Studies describe new findings in imaging research
Imaging - U.S. FDA clears 3D imaging system with cardiac navigation technology
Imaging - U.S. FDA grants clearance for Toshiba's MRI system with advanced cardiac imaging applications
Imaging - Vulnerable plaques causing acute coronary syndrome are assessed using intravascular ultrasound
Ischemia - Hypercapnia uses nitrative stress to foil angiogenesis
Ischemia - Myocardial perfusion is improved by tibolone therapy in women with ischemic heart disease
Ischemia - Post-conditioning reduces infarct size in the isolated rat heart
Ischemia - Post-conditioning-induced cardioprotection mechanisms are investigated
Ischemia - Transient ischemic episodes modulate brain damage through action of prostaglandin receptors
Kidney Disease - In long-term peritoneal dialysis, volume control is associated with better cardiac function
Kidney Disease - Renal dysfunction predicts higher mortality in patients with acute coronary syndrome
Lung Transplantation - Ex vivo evaluation called valuable for some nonacceptable donor lungs
Medical Devices - ATS Medical reports first implant of Simulus annuloplasty ring
Medical Devices - Conor Medsystems licenses pimecrolimus from Novartis for use in reservoir-based drug-eluting stents
Medical Devices - Cypher stent shown to outperform Taxus stent in long complex lesions
Medical Devices - Low adverse cardiac events rate using embolic protection system in SVG treatment reported
Medical Devices - Medtronic's Endeavor stent continues to show consistent clinical efficacy and strong safety profile
Medical Devices - New research in the area of medical devices detailed
Medical Devices - Recent findings in medical devices described
Medical Devices - ScottCare introduces Nicore Advantage external counterpulsation solution for cardiac patients
Medical Devices - U.S. FDA approves expanded labeling of Medtronic CRT biventricular pacing systems
Medical Education - Virtual classroom proves better teacher for certain medical skills
Mental Health - Reports advance knowledge in mental health research
Mergers & Acquisitions - Novoste sells vascular brachytherapy business to Best Vascular
Migraine Headache - NMT Medical's MIST study indicates that closing a PFO has an effect on migraine
Myocardial Infarction - For myocardial infarction diagnosis, studies are needed to define optimal troponin threshold
Myocardial Infarction - Remodeling after myocardial infarction is unaffected by deletion of NADPH oxidase subunit
Neuropathy - Dichloroacetate causes toxic neuropathy in MELAS in clinical trial
Obesity Complications - Carotid artery stiffness and C-reactive protein were linked to metabolic syndrome in obese
Obesity Complications - Obesity is an independent risk factor for coronary heart disease mortality
Obesity Pathogenesis - CD11b expression and endothelial cell adhesion in monocytes is linked to high fatty acid levels
Obesity Pathogenesis - Leptin has a common link to obesity and hypertension
Obesity Pathogenesis - Researchers detail new studies and findings in the area of obesity pathogenesis
Obesity Surgery - Mayo Clinic researchers say bariatric surgery may reduce risk of heart disease
Obesity Therapy - Cardiovascular fitness in obese improved by 'Walking for pleasure'
Obstetrics - Adult hypertension and chronic kidney disease may be associated with low birth weight
Obstetrics - Changes in fetal echocardiography referral trends are focus of review
Obstetrics - Pregnancy complications increase women's risk of heart disease, death
Pacemakers - Pacemaker patients benefit from upgraded biventricular pacing
Pediatric Cardiology - Researchers' data advance pediatric cardiology research
Personnel - Cardium adds Kelly D. Scott as vice president of new medical technology business
Personnel - Guidant Cardiac Rhythm Management President R. Frederick McCoy elects early retirement
Personnel - Jeff L. Myers named chief of pediatric cardiothoracic surgery at Le Bonheur medical center
Personnel - MedCath names Phil Mazzuca as chief operating officer
Physiology - Intermedin activates aortic L-Arg/nitric oxide synthase/nitric oxide pathway
Proteomics - Crystal structure of apolipoprotein A-I offers insights into its protective cardiovascular effect
Proteomics - Deformability, dynamics, and remodeling of cytoskeleton of adherent living cells are considered
Proteomics - Proteomics of the heart and the study of cardiovascular disease are focus of review
Renal Angiomyolipomata - Renal angiomyolipomata in patients with tuberous sclerosis complex treated by embolization
Respiratory Medicine - Positive pressure-assisted breathing alters sympathetic baroreflex drive
Respiratory Medicine - Sleep-related breathing disorder therapies must be determined individually
SIDS - A genetic variant is probable cause of increased SIDS in African Americans
Statins - Findings advance knowledge in statins research
Statins - In rat model of heart failure, pravastatin increases survival, suppresses MMP activity
Statins - Pravastatin inhibits expression of lectin-like oxidized LDL receptor-1
Statins - Recent studies add new data to statins research
Statins - Reports advance knowledge in statins research
Statins - Statin-related adverse events are synthesized in a meta-analysis of clinical trials
Stem Cell Research - Adult stem cells improve cardiac function, blood flow in patients with heart disease
Stem Cell Research - Stem cells improved left ventricle wall thickness, capillary density following heart attack
Stroke - A neuroactive steroid may be a useful co-therapy with thrombolytics for stroke
Stroke - Cardiovascular risk factors and 5-year mortality in Copenhagen stroke study are reported
Stroke - Clopidogrel and aspirin did not reduce heart attack, stroke, or cardiovascular death risk in study
Stroke - For patients with atrial fibrillation, discontinuing warfarin over time is a cause for concern
Surgical Technology - Large-model femoral bypass graft exhibits better hemodynamics than smaller version
Surgical Technology - Michigan hospital utilizes Spy Intra-operative Imaging System to confirm success of heart surgery
Surgical Technology - Paclitaxel-eluting stent use, lumen diameter, and lesion length were predictors of restenosis
Surgical Technology - Restenosis is frequent after SES implantation for unprotected left main coronary artery lesions
Surgical Technology - Sirolimus-eluting stents induced redistribution of memory T lymphocytes in coronary sinus
Telemedicine - Low-income patients may reduce heart disease risk via internet
Tobacco Use - Recent studies add new data to tobacco use research
Transplant Medicine - After cardiac transplant, early stage graft vasculopathy is accompanied by hypersensitivity
Transplant Medicine - For heart transplant recipients, virtual crossmatch may improve organ availability
Transplant Medicine - Lymphoproliferative disorder is serious complicating outcome of cardiac transplantation
Transplant Medicine - Medwave's blood pressure monitoring technology studied in difficult liver transplant cases
Transplant Medicine - Pre-op creatinine clearance <40 ml/min is an outcome marker after orthotopic heart transplant
Type 2 Diabetes - Dopamine D3-RA had a positive effect on renal morphology and albuminuria in type 2 diabetes
Type 2 Diabetes - Postprandial deterioration of endothelial dysfunction in diabetes is decreased by vitamin C
Vascular Disease - Cleveland Clinic reports research results of aspirin alone, in combination with clopidogrel
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