Published in Heart Disease Weekly, April 11th, 2006
"Essential hypertension is frequently associated with insulin resistance of skeletal muscle glucose transport, and angiotensin II(ANGII) can contribute to the pathogenesis of both conditions. The male heterozygous TG(mREN2)27 rat (TGR) harbors the mouse transgene for renin, exhibits local tissue elevations in ANGII and is an excellent model of both hypertension and insulin resistance associated with...
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