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Cardiovascular Research

Hypertrophic, myotoxic effects of clenbuterol are dose-determined in rat model

Published in Heart Disease Weekly, July 2nd, 2006

The hypertrophic and myotoxic effects of the beta2 -adrenergic receptor agonist clenbuterol are dose-determined in a rat model.

According to recent research from England, "Muscle growth in response to large doses (milligrams per kilogram) of beta2 -adrenergic receptor agonists has been reported consistently. However, such doses may also induce myocyte death in the heart and skeletal muscles and hence may not be safe doses for humans."

"We report the hypertrophic and myotoxic effects of different doses of clenbuterol," wrote J.G. Burniston and colleagues at Liverpool John Moores University. "Rats were infused with clenbuterol...

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