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Fetal Cardiology

Proliferation, not apoptosis, in embryonic mouse heart is affected by maternal folate deficiency

Published in Heart Disease Weekly, September 3rd, 2006

Proliferation of the embryonic myocardium is sensitive to maternal dietary folate, and folate supplementation during pregnancy is important for normal heart development and prevention of heart defects.

According to recent research published in the Journal of Nutrition, "Low dietary folate and deficiency of methylenetetrahydrofolate reductase (Mthfr) were reported to increase the risk for congenital heart defects, but contributory mechanisms have not been elucidated."

"Because low folate and absent MTHFR activity were shown to affect proliferation and apoptosis in developing neural tissue, we examined these processes in the myocardium of...

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