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Cardiovascular Disease

Coronary artery disease patients show increased plasma concentrations of matrix metalloproteinase-7

Published in Heart Disease Weekly, October 8th, 2006

Coronary artery disease patients show increased plasma concentration of matrix metalloproteinase-7.

According to a study from Sweden, "Plaque rupture is often associated with breakdown of the extracellular matrix in the shoulder region of a plaque. We tested whether plasma concentrations of various matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase-1 (TIMP-1) could serve as markers for plaque instability as well as relationships between plasma MMPs and inflammatory markers."

"The study group included 65 men with angiographically verified CAD (45 with stable and 20 with unstable CAD) and 28 healthy controls," wrote L. Nilsson...

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