Published in Heart Disease Weekly, October 22nd, 2006
According to investigators in Israel, "Tissue-type plasminogen activator (tPA) regulates vascular contractility through the low-density lipoprotein-related receptor (LRP), and this effect is inhibited by plasminogen activator inhibitor type 1 (PAI-1). We now report that tPA-mediated vasocontraction also requires the integrin alphav beta3 ."
S. Akkawi and colleagues at Hadassah University Hospital in Jerusalem wrote, "tPA-induced contraction of rat aortic rings is...
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