Obesity and Diabetes

Despite Overeating, Morbidly Obese Mice Gain Protection Against Diabetes

Published in Heart Disease Weekly, September 9th, 2007

The “world’s fattest mice” can overeat without developing insulin resistance or diabetes thanks to a glut of a key hormone, a dichotomy that helps explain why not all obese people are diabetic, a UT Southwestern Medical Center researcher has found.

Consuming excess calories usually spurs insulin resistance and diabetes. But in a multicenter study appearing online today in the Journal of Clinical Investigation, scientists show how an abundance of adiponectin, a hormone that controls sensitivity to insulin, and a lack of leptin, a hormone that curbs appetite, enables mice to store excess calories in fat tissue instead of in liver, heart or muscle tissue – places where...

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Source: Heart Disease Weekly (2007-09-09)

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