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Heart Failure

Studies in the area of heart failure reported from University of Nebraska

Published in Heart Disease Weekly, October 7th, 2007

Current study results from the report, "NADPH oxidase-derived superoxide anion mediates angiotensin II-enhanced carotid body chemoreceptor sensitivity in heart failure rabbits," have been published. "A previous study from this laboratory showed that elevation of endogenous angiotensin II (Ang II) and upregulation of the angiotensin II type 1 (AT(1)) receptor in the carotid body (CB) are involved in the enhanced peripheral chemoreceptor sensitivity in rabbits with chronic heart failure (CHF). NADPH oxidase-derived superoxide anion mediates the effects of Ang II in many organs," scientists in the United States report.

"We investigated whether this signaling pathway may...

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