Heart Disease Weekly
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Ventricular Fibrillation
Study results from J. Bai et al provide new insights into ventricular fibrillation
December 28th, 2008
"Sympathetic denervation is frequently observed in heart disease. To investigate the linkage of sympathetic denervation and cardiac arrhythmia, we developed a rat model of chemical sympathectomy by subcutaneous injections of 6-hydroxydopamine (6-OHDA)," scientists writing in the Canadian Journal of Physiology and Pharmacology report. "Cardiac sympathetic innervation was visualized by means of a glyoxylic catecholaminergic histofluorescence method. Transient outward current (I-to) of ventricular myocytes was recorded with the whole-cell configuration of the patch clamp technique. We observed that sympathectomy (i) decreased cardiac sympathetic nerve density and...
Source: Heart Disease Weekly (2008-12-28)
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