Heart Disease Weekly
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Enzyme Research
Data on enzyme research discussed by researchers at National Taiwan University
June 21st, 2009
"Infective endocarditis is characterized by inflammatory infiltrates of mononuclear cells in infected cardiac valve leaflets. To delineate the role of valve interstitial cells (VICs) in leukocyte recruitment, we stimulated human VICs with glucosyltransferase, a modulin from viridians streptococci," scientists in Taipei, Taiwan report. "Interstitial cells were activated directly by glucosyltransferase in a dose-dependent manner through concerted mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways; activation resulted in up-regulation of synthesis and release of interleukin-6, interleukin-8, or monocyte chemoattractant protein-1 and enhanced...
Source: Heart Disease Weekly (2009-06-21)
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