Follicular Lymphoma

Flow cytometry can give differential diagnosis by bcl-2 expression level

Published in Hematology Week, March 10th, 2003

Recent research in the United States tested for "the expression of bcl-2, CD10, and CD20 was examined by multicolor flow cytometry in 78 samples including lymph node or other tissue biopsy specimens containing follicular lymphoma (FL; n=17), reactive hyperplasia (RH; n=28), or other malignant lymphomas (n=20), as well as bone marrow aspirates (n=13).

"The presence of CD10+ cells with high bcl-2 expression predicted the presence of FL rather than RH with a positive predictive value of 100% and negative predictive value of 96%. CD10+ cells with high bcl-2 expression also were found in a subset of diffuse large B-cell lymphomas and were otherwise rare in other types of...

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Source: Hematology Week (2003-03-10)

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