Transplant Medicine
HLA-G may be factor in graft rejection
Published in Hematology Week, March 10th, 2003
According to a study from France, "The human MHC class I molecule HLA-G has long been known as a molecule selectively expressed by cytotrophoblastic cells. By inhibiting the cytolytic function of decidual NK cells, HLA-G protects the HLA-A and HLA-B negative semiallogeneic embryonic tissue against the maternal immune system. In light of this immunosuppressive function, the role of HLA-G in transplantation was investigated.
"We will review here recently published data on this topic, showing that expression of HLA-G affects the responsive capacity of the immune system, might directly participate in graft acceptation, and should be taken into account for the monitoring...
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Source: Hematology Week (2003-03-10)
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