Acute Lymphoblastic Leukemia

Cases of symptomatic epilepsy associated with intracranial calcifications

Published in Hematology Week, March 10th, 2003

According to recent research from Croatia, "Acute and long-term sequels of central nervous system (CNS) prophylaxis with irradiation and intrathecal chemotherapy in children suffering from acute lymphoblastic leukemia (ALL) include vasculopathies, leucoencephalopathies, intracranial calcifications, intellectual and neurological impairment.

"We report two children at the age 5 and 8 years who manifested partial motor or complex seizures and intracranial calcifications 2 - 4 years after the diagnosis of ALL had been established. The occurrence of these disorders was much earlier than reported in the literature.

"Both children received prophylactic CNS...

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Source: Hematology Week (2003-03-10)

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