Diagnostics

Two mass spectrometry methods comparably measure total homocysteine in serum

Published in Hematology Week, November 10th, 2003

Two forms of mass spectrometry are found comparable in accurately determining total homocysteine in plasma, serum.

According to a study from the United States, "Two independent methods have been critically evaluated and applied to the measurement of total homocysteine in serum and plasma: solid-phase anion extraction (SPAS) gas chromatography/mass spectrometry (GC/MS) and protein precipitation liquid chromatography/tandem mass spectrometry (LC/MS/MS). In addition, analysis of samples prepared by SPAS was accomplished by liquid chromatography/mass spectrometry (LC/MS) and LC/MS/MS.

"These methods have been used to determine total homocysteine levels...

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Source: Hematology Week (2003-11-10)

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