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HIV/AIDS Pathogenesis

Prognostic CCR5 mutations affect co-receptor expression

Published in Hematology Week, November 10th, 2003

Prognostically useful CCR5 mutations affect the density of the HIV co-receptor on mononuclear cell surfaces.

"The common CCR5 promoter polymorphism at position -2459 (A/G) has been associated with differences in the rate of progression to AIDS, where HIV-1-infected individuals with the CCR5-2459 G/G genotype exhibit slower disease progression than those with the A/A genotype," scientists in Cleveland explained. However, the "mechanisms underlying the relationship between these polymorphisms and disease progression are not known."

In a recent study examining "in vitro infection of peripheral blood mononuclear cells obtained from healthy Caucasian...

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