Leukemia Therapy
MEN 11079 shows promise as antileukemic agent
Published in Hematology Week, November 10th, 2003
In a recent study from Italy, "The biological activity of MEN 11079, a new daunorubucin analogue with a fluorine atom in C-8 of ring A, was investigated in the human leukemic cell lines K-562 and in mononuclear cells (MNCs) of 40 patients with acute myeloid leukemia (AML) and the activity compared to two well-characterized anthracyclines, idarubicin (IDA) and doxorubicin (DOXO)."
"IDA and MEN 11079 were more active than DOXO in cytotoxicity tests (WST-1 assay)," reported M. Biscardi and coauthors at the University of Florence. "IDA and MEN 11079 ID50 values were also significantly...
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Source: Hematology Week (2003-11-10)
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