Malaria Pathogenesis

Malaria parasite egress from host erythrocytes clarified

Published in Hematology Week, November 10th, 2003

The process of malaria parasite egress from infected erythrocytes has been clarified, and may represent a therapeutic target.

"Escape from the host erythrocyte by the invasive stage of the malaria parasite Plasmodium falciparum is a fundamental step in the pathogenesis of malaria of which little is known," scientists in Australia explained. "Upon merozoite invasion of the host cell, the parasite becomes enclosed within a parasitophorous vacuole, the compartment in which the parasite undergoes growth followed by asexual division to produce 16-32 daughter merozoites. These daughter cells are released upon parasitophorous vacuole and erythrocyte membrane...

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Source: Hematology Week (2003-11-10)

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