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Hematology Week

Susan Hasty, Publisher

Table of Contents . . . December 15th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Hematology Week | Other Publications

Hematology - ABO blood type and race affects von Willebrand factor activity

Thrombophilia - Oral contraceptives and the factor V Leiden mutation increase thrombosis risk

Hematology - An antiangiogenic approach is key to managing multiple myeloma

Immunotherapy - Risks associated with use of intravenous immunoglobulin reviewed

Stem-Cell Research - Culture system for growth of c-Kit(-) hematopoietic cells developed

Adoptive Cellular Therapy - CMV-specific T cells useful in combating post-transplant CMV infection

Allergy Medicine - Human HtrA1 is found in many human tissues with secretory function

Allergy Medicine - Peroxisome proliferator activated receptor ligands can lower IgE, some cytokines

Asthma - Underlying airway smooth muscle may have immunomodulatory effects in asthma

B-Cell Subtypes - Peripheral lymphoid tissue has large B cells similar to thymic asteroid cells

Burn Medicine - Non-fibrin keratinocyte cell sprays may be superior to fibrin-based sprays

Cancer Therapy - Safety and efficacy of IL-6 mAb therapy reviewed

Cancer Vaccine - Immunotherapy of AMLs: Development of vaccines and cell therapy approaches

Celiac Disease - There are many immunogenic sequences in gluten; they bind HLA, activate T cells

Cerebral Malaria - Inhibition of platelet adherence in brain protects mice against severe cerebral malaria

Critical Care Medicine - Organizational approach more effective than education in reducing diagnostic blood loss

Cystic Fibrosis - Surfactant protein D increases with lung dysfunction, not aspergillosis in CF

Dendritic-T Cell Interactions - Antigen-specific T cells induce MHC-II tube-shaped vesicles in dendritic cells

Drug Development - Biotin derivative blocks Plasmodium-induced permeation pathways in infected erythrocytes

Epstein-Barr Virus - Germinal center B cells appear to be those susceptible to EBV transformation

Gastroenterology - Causes of bleeding in GI angiodysplasia elucidated

Guillain Barre Syndrome -  Campylobacter jejuni infection leads to GBS via improper antibody regulation

HIV/AIDS - Hemoglobin levels strongly predict HIV progression

HIV/AIDS Therapy - Anemia management in chronic HIV patients reviewed

Human Leukocyte Antigen - HLA-B alleles B*4414 and B*5708 are found in European Caucasians but are rare

Immunology - Complement system plays key role in GBS-induced TNF-alpha release

Immunology - Innate immune system fully functional in neonates

Immunology - Natural killer, NK T cells produce rapid IL-4, IFNgamma due to collected mRNAs

Immunosenescence - CD8+ T cells may have higher levels of internal cytokines as humans age

Infectious Disease - Serum albumin level linked to HFRS severity

Inflammation - Macrophages oxidize ECM; LPS, IgG increases effect, dexamethasone lowers it

Kidney Transplantation - Daclizumab can slowly replace cyclosporine therapy; avoids long-term renal damage

Leukemia Animal Models - Murine model of megakaryocytic myeloproliferative syndrome developed

Leukemia Therapy - BACH2 expression can augment the cytotoxic effects of anticancer agents

Leukemia Therapy - Loss of post-SCT immune VZV control and leukemia relapse may be linked

Leukemia Therapy - Use of immunoregulatory cells in stem cell transplantation reviewed

Malaria Pathogenesis -  P. falciparum uses erythrocyte vesicle transport system for protein transport

Multiple Myeloma Therapy - High-dose VAD with auto-SCT effective for acute MM patients

Multiple Sclerosis - CD8+ T cells in MS types are correlated to adverse MRI lesion load features

Neurological Disease - Serum anti-Fas antibody levels aren't specific for amyotrophic lateral sclerosis

Neuromuscular Disease - Lack of dysferlin gives high MHC-I, macrophage; no cytotoxic T cells in muscle

Pediatric Hemodialysis - Novel pre-dialysis treatment normalizes blood prime pH and electrolyte levels

Prognostic Modeling - Immunosuppressive therapy response in myelodysplastic syndrome is predictable

Protein Folding - The lipocalin superfamily has conserved residues involved in protein folding

Psychology - Atopic dermatitis can be caused by psychological stress; immunity is altered

Rheumatology - French studies on early arthritis provide risk factors as well as clinical data

Semen Granulocytes - Male accessory gland inflammation can be detected through leukocytospermia

Stem-Cell Research - Cell fusion: an alternative to stem-cell plasticity?

Stem-Cell Research - Emu-GFP-3'LCR transgene forces B lineage expression

Stem-Cell Research - Mesenchymal stem cells can differentiate into neuron-like cells in vitro

Stem-Cell Research - Thrombopoietin stimulates Hoxb4 expression by primitive hematopoietic cells

Stem-Cell Transplantation - Cytomegalovirus prophylaxis for allo-SCT recipients reviewed

Stem-Cell Transplantation - First case of DLI-linked nephrotic syndrome described

Stem-Cell Transplantation - Late post-SCT diversification of CMV-specific CD8 cells possible

Stem-Cell Transplantation - Safety and efficacy of nonmyeloablative SCT reviewed

Transfusion Medicine - Antibody screens for Mongoloid populations should include Di(a) panel cells

Transplant Medicine - Acute liver rejection occurs most often if early steriods are not used

Transplant Medicine - Serial serum protein electrophoresis can be used to monitor PTLD following transplantation

West Nile Risk - West Nile virus can cause death, no IgM, in bone marrow transplant recipients

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