Genomics
LCR promotes beta-globin transcription repression in committed cells
Published in Hematology Week, May 10th, 2004
"During erythroid differentiation, beta-globin gene expression is regulated by the locus control region (LCR). The transcription factor NF-E2p18/MafK binds within this region and is essential for beta-globin expression in murine erythroleukemia (MEL) cells. Here we use the isotope-coded affinity tag (ICAT) technique of quantitative mass spectrometry to compare proteins interacting with NF-E2p18/MafK during differentiation," wrote scientists at the Fred Hutchinson Cancer Research Center.
Results "define MafK as a 'dual-function' molecule that shifts from a repressive to an...
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Source: Hematology Week (2004-05-10)
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