DNA Damage

Attenuated p53 response in preneoplastic lesions growth advantage under stress

Published in Hematology Week, June 28th, 2004

Attenuated p53 response in preneoplastic lesions gives a growth advantage under stress.

According to published research from Sweden, "In the present study p53(+/-) and p53(+/+) C57BL/6 female mice were administered diethylnitrosamine (DEN) once each week for 15-20 weeks. After sacrifice we analyzed the number and size of preneoplastic liver lesions, and found that the same numbers of lesions of similar sizes developed in the two genotypes of mice."

"We also distinguished between two phenotypes: 'p53-positive' and 'p53-negative' lesions (i.e., lesions with or without a p53 response to DNA damage," reported N. Finnberg and coworkers, "as assessed by...

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Source: Hematology Week (2004-06-28)

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