Leukemia
Variant MYST4-CBP gene fusion found in t(10;16) acute myeloid leukemia
Published in Hematology Week, August 2nd, 2004
According to published research from France, "We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukemia (AML)-M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4-CBP and CBP-MYST4 chimeric transcripts were products of in-frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively."
"The potential resulting chimeric proteins showed similarities with MYST3-CBP, MYST3-P300 and MYST3-NCOA2 putative fusion proteins found in other cases of AML," wrote...
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Source: Hematology Week (2004-08-02)
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