Hematology Week
Susan Hasty, Publisher
Table of Contents . . . November 22nd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Hematology Week | Other Publications
Anti-Infective Agents - Sulfamates offer promise as anti-infective/anticancer agents
Diagnostics - Novel method detects/quantitates hemoglobin-based oxygen carriers in plasma
Drug-Resistant Staphylococcus Aureus - Molecular monitoring determines nosocomial dissemination of MSRA
Human Papillomavirus - Microscopy/RT-PCR identifies mechanisms of long-term HPV oral mucosal infection
Placental Barrier - Polychlorinated biphenyl pollutants cross the placental barrier
Acute Myelogenous Leukemia - Phenotypic karyotype markers identified in AML with t(8;21)
Angiology - The use of statins is associated with a reduced risk of venous thromboembolism
Anti-Inflammatory Agents - Resveratrol has novel nonsteroidal anti-inflammatory properties
Antiretroviral Therapy - Antiretroviral CSF penetration improves cognitive disorders in HIV infection
Antiviral Drug Development - Rab9 identified as a novel antiviral drug target
Apoptosis - Capillin induces apoptosis in tumor cells
Apoptosis - HTLV-1 Tax oncogene causes tumorigenesis
Arsenic Contamination - Reducing arsenic contamination often increases water-related infectious diseases
Artificial Blood - Loyola joins artificial blood study; patients to be tested without permission
Atherosclerosis - Nuclear medicine diagnostic techniques reviewed
Blood Banking - Diagnostic company launches blood bank educational initiative
Blood Banking - SC refrigeration is simple option for autotransplants within few days of harvest
Bone Marrow Transplantation - Bone marrow found for woman seeking South Asian donors
Bone Marrow Transplantation - Patients with impaired LV ejection fraction can achieve long-term survival
Bone Marrow Transplantation - Psychosocial/behavioral variables do not effect 1-year survival after BMT
Botulism - Eighty percent of botulism outbreaks attributed to home-preserved vegetables
Bovine Spongiform Encephalopathy - Scientists raise concerns about second wave of 'mad cow' prion infection
Business & Finance - Pharmaceutical firm reports loss of $0.32 per share, provides pipeline update
Business & Finance - Pharmaceutical updates divestiture process, clinical development projects
Cancer Therapy - Biopharmaceutical, MGI Pharma announce Dacogen MAA accepted for review by EMEA
Caprine Arthritis Encephalitis Virus - Caprine arthritis encephalitis virus isolated from sheep during epidemic
Cardiology - A new thrombosis and angiogenesis signaling pathway has diagnostic value
Cardiology - Antiplatelet agent slated for new Phase III trial
Cardiology - Kensey Nash provides update on TriActiv System FDA approval status
Cardiology - Six U.S. medical centers using NMR spectroscopy to manage heart disease
Chronic Lymphocytic Leukemia - Utility of antibody-based CLL treatments reviewed
Collaborations - Drug discovery company, Novo Nordisk collaborate on TTP translational technology
Colon Cancer - Novel Bcl-2 family gene associated with progression of colon cancer
Colon Cancer - Targeted therapy + efficient chemotherapy increases colorectal cancer survival
Colorectal Cancer - Excessive alcohol intake plus low folate increase risk of colorectal cancer
Complementary & Alternative Medicine - Studies suggest green tea/tea polyphenols lower cancer risk/inhibits tumors
Congenital Hypothyroidism - High prevalence of parental consanguinity in infants with permanent CH
Cytomegalovirus - Human cytomegalovirus-induced host cell enlargement is iron dependent
DNA Research - Automated scoring procedure developed for micronucleus test
Dermatology - Cells expressing nestin-driven marker model early skin angiogenesis
Diagnostics - A new assay improves the timeliness and sensitivity of hepatitis C detection
Diagnostics - Counting immunoassay detects hepatitis markers in whole-blood samples
Down Syndrome - Gene signatures of transient and acute megakaryoblastic leukemia identified
Drug-Resistant Enterococcus - Vancomycin-resistant E. facecalis disseminated between hospitals 100 km apart
Endocrinology - Combined oral contraceptives affect activated protein C resistance
Environmental Health - A long wait for Love Canal health study that promises no answers
Environmental Health - Health investigators link North Carolina E. coli cases
Epidemiology - Human disease outbreaks are bioindicators of ecologic well-being
Epstein-Barr Virus - Rheumatoid factors induce signaling from B cells and lead to EBV activation
Finance - Pharmaceutical company completes financing round in support of clinical development
Formaldehyde Exposure - Formaldehyde-induced DNA adducts biomarkers of nasal cell formaldehyde exposure
Genital Herpes - Viral shedding explored as a surrogate marker for genital herpes transmission
Glioblastoma - 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells
HIV/AIDS Drug Resistance - Incomplete HIV suppression may account for resistant mutations in brain
HIV/AIDS Epidemiology - Use of blood donor data for HIV surveillance does not reflect normal population
HIV/AIDS Genetics - HIV-1 recombination is a major evolutionary force affecting genetic variation
HIV/AIDS Pathogenesis - Non-syncytia-inducing HIV inhibits replication of syncytia-inducing strains
HIV/AIDS Perinatal Transmission - Nevirapine does not prevent perinatal HIV-1 transmission in the field
HIV/AIDS Research - 2-Aminopurine fluorescence binding assay quantitates HIV-1 TAR interactions
HIV/AIDS Research - CD4 infection with infectious HIV-1 leads to IL-2 promoter hyper-responsiveness
HIV/AIDS Research - CD4+ cell loss in T-tropic HIV-1 infection is not directly mediated by apoptosis
HIV/AIDS Research - Conserved carboxy terminus of HIV-1 Gag important for virion assembly/release
HIV/AIDS Research - Cyoplasmic p53 may enhance the accuracy of HIV-1 RT DNA synthesis
HIV/AIDS Research - Determinants within gp120 and gp41 contribute to CD4 independence of SIV Env
HIV/AIDS Research - HIV-1 integration sites flanked by potential MARs can act as promoters
HIV/AIDS Research - HIV-infected CD8 lymphocytes generated through infection of activated CD8 cells
HIV/AIDS Research - Hsp70 protects cells from cell cycle arrest and apoptosis induced by HIV-1 Vpr
HIV/AIDS Research - IgMs selectively cleave HIV gp120 by a nucleophilic mechanism
HIV/AIDS Risk - Adolescent woman may be more susceptible to HIV infection than men in Cameroon
HIV/AIDS Screening - HIV screening inadequate in North Carolina jails
HIV/AIDS Therapy - Antiretroviral treatment decisions based on toxicity/resistance/convenience
HIV/AIDS Therapy - Each nucleoside/nucleotide backbone of HIV therapy has its advantages
HIV/AIDS Therapy - HIV viral load after 4 weeks of HAART predicts virologic outcome at 24 weeks
HIV/AIDS Therapy - Improved activity of abacavir prodrug due to increased CBV-TP metabolites
HIV/AIDS Therapy - Mechanism elucidated for bleomycin inhibition of HIV-1
HIV/AIDS Therapy - NRTIs decrease mitrochondrial DNA synthesis and oxidative enzyme content
HIV/AIDS Therapy - Quality of life increased with enfuvirtide plus optimized background regimen
HIV/AIDS Therapy - Safety data should not be extrapolated from early to new HIV protease inhibitors
HIV/AIDS-Related Cardiology - Surgical drainage not justified in AIDS-related cardiac tamponade
HIV/AIDS-Related Depression - Nonadherence to HAART independently associated with depression
HIV/AIDS-Related Insulin Resistance - Indinavir increases glucose production in healthy HIV-uninfected men
HIV/AIDS-Related Mycobacterium - Mycobacterium avium complex infection in HIV infection rare in the era of HAART
HIV/AIDS-Related Nutrition - Nutrition management is complicated in HIV-infected persons
HIV/AIDS-Related Renal Disease - Increased prevalence of HIV-related end-stage renal disease is minimal
HIV/AIDS-Related Wasting Syndrome - Hyperphagia contributes to normal body composition in asymptomatic HIV infection
Hantavirus - Hantavirus pulmonary syndrome outbreak documented in Los Santos, Panama
Hematology - Mice expressing defective human factor IX aid hemophilia B research
Hemophilia - Regulatory application submitted in Japan for Advate
Hemophilia B - Factor IX replacement postpartum may prevent bleeding in women with deficiency
Hepatitis - Hepatitis study information presented at conference
Hepatitis A Virus - Ninety-two people infected with hepatitis A in central Romanian
Hepatitis B Virus - Hepatitis B cases down 89% among children, adolescents
Herpes Simplex Virus - HSV-1 VP16 recruits general transcription factors/coactivators to IE promoters
Herpesvirus - E2F1/CDK2 promoter activation requires N- and C-terminal regions of KSHV LANA
Herpesvirus - Kaposi sarcoma-associated herpesvirus immediate early gene activity explored
Human Herpesvirus 6 - DC-SIGN expression altered at transcriptional level by HHV-6 infection
Hypertension - Health Canada approves therapeutic breathing device to lower blood pressure
Hypertension - Progress is expected to lead to specific antihypertensive treatments
Hypotension - Arterial BP control based on neural network during acute hypotension reported
Immunology - Fresh blood and liver natural killer cells demonstrate genetic differences
Immunology - Novel assay provides simultaneous measure of serum and PBMC cytokines
Insulin Resistance - Fad diets high in saturated fats can induce insulin resistance
JC Virus - PMA and IL-1beta dramatically increase JC virus transcription in glial cells
Kaposi Sarcoma Herpesvirus - KSHV ORF36 protein kinase activates c-Jun N-terminal kinase signaling pathway
Kaposi Sarcoma-Related Herpesvirus - Poly(ADP-ribose) polymerase 1 binds to KSHV TR and modulates latency replication
Leishmania - Leishmania donovani activates NF-kappaB in macrophages through ROS intermediates
Leukemia - Antiviral therapy for adult T cell leukemia lymphoma is promising
Leukemia - Obesity increases older women's risk of acute myelogenous leukemia
Leukemia - Orphan drug designation granted for the treatment of leukemia
Leukemia - Signaling mechanisms underlie human leukemia cell life/death switching
Leukemia - U.S. FDA grants orphan drug designation to acute myelogenous leukemia drug
Leukemia Therapy - Guidelines to define therapeutic strategies for leukemia described
Lung Cancer - cis-Pt(II) complex of 3-aminoflavone induces lung tumor apoptosis and necrosis
Lysosomal Storage Disease - Modified bone marrow cells improve cognition in mucopolysaccharidosis models
Malaria - Platelet count is an important clue to the diagnosis of malaria
Malaria - Submicroscopic P. falciparum infection may affect immunity during pregnancy
Malaria - Weather monitoring warns of malaria epidemics in African highlands
Medical Devices - Biotech company submits FDA application to market blood component separator
Minibodies - Antibody research to be published in hematology journal
Motor Neurons - Embryonic SC-derived motoneurons develop appropriate transmitter receptors
Murine Leukemia Virus - Real-time PCR evaluates X-MuLV removal during protein purification
Myocardial Infarction - Bone marrow cells can acquire cardiac phenotype in vivo
Natural Products - HIV-1 inhibitory compounds isolated from Calophyllum brasiliense leaves
Neonatal Sepsis - High-risk-based antibiotic prophylaxis better prevents onset of GBS sepsis
Neural Stem Cell Research - Beta1 integrins mediate stratum-derived neural SC adhesion and migration
Non-Hodgkin Lymphoma - BEAM with only cytokine support effective in high-risk patients
Organ Donation - Marrow donor program celebrates 20,000 transplants facilitated
Pediatric Cancer - Nongenetic causes are most likely risk factors for childhood cancer development
Pediatric Leukemia - Donor characteristics/herpesvirus exposure impact survival in pediatric leukemia
Percutaneous Coronary Intervention - Integrin beta3 regions that control binding of murine mAb 7E3 identified
Photoaging - Solar UV irradiation reduces collagen by blocking TGF-betaRII/Smad signaling
Polyomavirus - Polyomavirus infection in pediatric renal transplants monitored via PCR
Preeclampsia - Animal model has features of gestational hypertension
Preeclampsia - Common thrombophilia gene variants not risk factors for preeclampsia
Prostate Cancer - CYP1B1 and PR polymorphisms may be associated with prostate cancer risk
Pythiosis Therapy - Pythium insidiosum antigens effective against vascular pythiosis
Quality of Life - Physically active HIV-infected persons have higher life satisfaction
Renal Disease - U.S. FDA approves phosphate binder for patients with end-stage renal disease
Reperfusion - Delta-opioid receptor may play a role in ischemic preconditioning
Rotavirus - Rotavirus serotype G9P[8] responsible for outbreak in Northern Australia
Salmonella - Ingested Salmonella dose correlates with disease rate
Sepsis - Active hemoglobin enhances LPS-induced injury to endothelial cells
Skeletal Myoblast Transplantation - Skeletal myoblast grafts generated heterogeneity of Ca2+i ) signaling
Stem Cell Research - California stem cell vote means competition for University of Minnesota
Stem Cell Research - Hypoxia triggers stem cell proliferation followed by neuronal SC differentiation
Stem Cell Research - Molecular phenotype of renal progenitor cells identified
Stem Cell Research - Nuclear reprogramming is a key to stem cell function in regenerative medicine
Stem Cell Research - Self-renewal and multipotency demonstrated in stem cells
Stem Cell Research - Telomerase maintained in self-renewing tissues during serial regeneration
Stem Cell Transplant-Related Aspergillosis - Aspergillosis occurs later after reduced intensity versus regular SCT
Stem Cell Transplantation - Daily IV busulfan + cyclophosphamide for 4 days followed by SCT may be toxic
Stem Cell Transplantation - Multiagent strategy lowers regimen-related toxicity in children undergoing HSCT
Stem Cells - Cancer center doctor receives $25,000 award for research
Stomach Cancer - Hot-water extracts from adzuki beans reported to suppress tumorigenesis
Stroke - MRI-detectable microbleeds linked to cognitive impairment
Synthetic Blood - Synthetic red blood cell being tested at three medical schools in U.S. and Canada
Tuberculosis - Effective TB control requires treatment to include nonactive disease
Virology - CMV UL76 encodes novel virion-associated protein that inhibits viral replication
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