Alcoholic Liver Disease

Intracellular SAH removal may be therapeutic option in alcoholic liver disease

Published in Hematology Week, December 6th, 2004

Intracellular S-adenosylhomocysteine removal may be a therapeutic option in alcoholic liver disease.

According to a study from the United States, "In alcoholic liver disease, tumor necrosis factor-alpha (TNF-alpha) is a critical effector molecule, and abnormal methionine metabolism is a fundamental acquired metabolic abnormality.

"Although hepatocytes are resistant to TNF-alpha-induced killing under normal circumstances, previous studies have shown that primary hepatocytes from rats chronically fed alcohol have increased TNF-alpha cytotoxicity. Therefore, there must be mechanisms by which chronic alcohol exposure "sensitizes" to TNF-alpha...

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Source: Hematology Week (2004-12-06)

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