Hematology Week

Anti-Inflammatory Therapy - Modulation of iron metabolism a potential approach for anti-inflammatory therapy

Antioxidants - Reactive oxygen species mediate RANK signaling in osteoclasts

Colorectal Cancer - Functional polymorphism in E-cadherin gene associated with colorectal cancer

Resveratrol - Toxicity from resveratrol seen only at the highest dose tested

Stomach Cancer - COX-2 overexpression may contribute to carcinogenesis

Acute Myeloid Leukemia - Elevated AFlq gene expression is an independent adverse prognostic factor in AML

Acute Myeloid Leukemia - MNK1 is target of several leukemogenic fusion proteins

Acute Myeloid Leukemia - Multiplex PCR profiles minimal residual disease gene expression in AML

Antibiotic Resistance - Quantitative PCR is a reliable method for determining antibiotic susceptibility

Anticoagulants - Management varies for patients at risk for bleeding due to anticoagulants

Anticoagulation Therapy - Ximelagatran is a promising anticoagulant to decrease risk of embolic events

Antimicrobial Resistance - Bayesian model predicts risk of emerging resistance to antimicrobials

Antimicrobials - Plant extracts show antimicrobial activity against Gram-positive bacteria

Apoptosis - Cyclin B1 is a critical target of RhoB in the cell suicide program

Apoptosis - MKP-1 induction by proteasome inhibitors plays an antiapoptotic role

Apoptosis - NAC enhances hypoxia-induced apoptosis through NfkappaB inhibition

Apoptosis - Rho/rhotekin-mediated NF-kappa B activation confers resistance to apoptosis

Apoptosis - Sox4 CD is a pivotal pro-apoptotic domain to induce apoptotic cell death

Apoptosis - TRAF6 essential in mediating p75 signal transduction/apoptosis induction

Artificial Heart - Compact centrifugal blood pump with magnetically levitated rotor devised

Axonal Degeneration - Endogenous erythropoietin mediated pathway prevents axonal degeneration

Biomedical Engineering - Mandible reconstruction with bone grafts/platelet rich plasma is effective

Bladder Cancer - 9p21 aberrations induced by tobacco smoke associated with bladder cancer risk

Bone Marrow Cell Research - SF-1/Ad4BP transforms cultured BM cells into ACTH-responsive steroidogenic cells

Bone Marrow Transplantation - Transfusion-related acute lung injury possible after allo-BMT

Breast Cancer - Aurora A Ile/Ile genotype significantly associated with breast cancer risk

Business & Finance - Science-based pharmaceutical company reports Q4, full-year 2004 results

Business Update - Clinical lab company wins federal contract for hematology, urinalysis products

Business Update - Global Med Technologies announces milestone SafeTrace installation

Business Update - Medical device company extends contract to supply hemostatic bandages

Cancer Cell Suppression - TG2 suppression may retard differentiation of chronic myelogenous leukemia cells

Cancer Prevention - Citrus fruit consumption positively associated with GST enzyme activity

Cancer Therapy - Addition of water-soluble antioxidants increases quercetin anticancer activity

Cancer Therapy - Gene sets are indicted in glucocorticoid-induced leukemic cell death

Cardiology - Cardiovascular device company comments on HeartMate II clinical study filing

Cardiovascular Devices - Leakage flow rate and wall shear stress determined in biocentrifugal VAD

Cell Biology - Autofluorescence detects single living cells in microfluidic systems

Chemotherapy - Doxorubicin inhibits DNMT1 and results in conditional apoptosis

Chronic Lymphocytic Leukemia - Constitutive expression of MMP-9 dependent on p38-activity

Cold Hemagglutinin Disease - Cryofiltration apheresis effective as last-resort treatment

Collaborations - Alliance formed to research childhood leukemia biomarkers

Collaborations - Joint stem-cell research program launched

Colon Cancer - APC E 1317Q/I1307K germ-line variants not detected in sporadic colon cancer

Colon Cancer - GADD153 protein may be important for curcumin-induced apoptosis

Colorectal Cancer - Avastin plus FOLFOX4 chemotherapy regimen clinical trial results reported

Colorectal Cancer - Biallelic/monoallelic MYH gene mutations associated with colorectal cancer risk

Complementary & Alternative Medicine - Nonprescription plant-based drug to lower cholesterol introduced

Cord Blood Cell Research - Higher temperature increases megakaryopoiesis in cord blood cell cultures

Crosslinking - Optimal crosslinking conditions determined for cholesterol removal from milk

Cryopreservation - Company anticipates developing first adult oriented stem cell bank

Cryptosporidium Parvum - Two Cryptosporidium parvum genotypes caused recreational water outbreak

Cytoskeleton - Actin cytoskeletal organization analyzed, basis of regulation revealed

Diagnostics - Blood tests might eliminate tissue extractions in leukemia, lymphoma patients

Diagnostics - Molecular assays to replace current modes of detecting bloodstream infections

Diagnostics - Quantitative biofilm assay/plate screens enteroaggregative E. coli

Diagnostics - Rapid whole-body MRI used to image therapeutic response in bone marrow

Diagnostics - Researchers' work adds to diagnostics body of knowledge

Drug Development - HIV/HTLV-1 protease inhibitors and antimalarial compounds developed

Drug Research - Heparin cofactor II-deficient mice studied, antithrombotic activity revealed

Embryonic Stem Cell Research - Ceramide-induced apoptosis eliminates residual pluripotent EBCs after SCT

Embryonic Stem Cell Research - Wnt11 facilitates ESC differentiation to Nkx2.5-positive cardiomyocytes

Embryonic Stem Cell Research - Zap3 overexpression reduces telomerase activity during ESC differentiation

Endothelial Cell Production - Ursodeoxycholic acid inhibits endothelin-1 production in vascular endothelium

Environmental Exposure - Industrial residues from household-wax manufacturing are mutagenic

Fibrinogen - Fibrinogen-binding surface protein Fbl of S. lugdunensis characterized

Finance - Stem cell research company completes $755,000 private placement

Finance - Stem cell-focused biotechnology company announces completion of IPO

Finance - Thalomid maker reports strong revenue growth and profits

Gene Expression - Glycolysis genes are ubiquitously overexpressed in 24 cancer classes

Gene Expression - Myeloid leukemic cells express genes expressed in normal nonhematopoietic tissue

Gene Research - von Willebrand factor studied, multi-effect mutation revealed

Geriatrics - Pilot program with toolkit, assessment for elderly cancer patients launched

HAART Monitoring - HPLC/UV effective for therapeutic antiretroviral drug monitoring

HIV/AIDS Coinfection - HAART immune reconstitution trigger adverse effects in M. leprae coinfection

HIV/AIDS Pathogenesis - CCR5/CCR2 genetic variants not responsible for maintenance of HIV nonprogression

HIV/AIDS Pathogenesis - Changes in HIV-1 V3 region correspond with disease progression

HIV/AIDS Pathogenesis - HIV-1 gp120 reduces brain-derived neurotrophic factor levels

HIV/AIDS Pathogenesis - Improved control of HIV-2 infection may relate to contribution of CD4 response

HIV/AIDS Pathogenesis - Studies add new findings to HIV/AIDS pathogenesis body of knowledge

HIV/AIDS Prevention - HIV-infected gay men acknowledge risky sex behavior

HIV/AIDS Research - Annexin II may be new target for prevention of HIV-1 infection

HIV/AIDS Research - Peptides specifically binding to HIV-1 psi RNA selected/characterized

HIV/AIDS Screening - HIV screening based on patient complaint is cost-effective in low-resource areas

HIV/AIDS Therapy - Curcumin inhibits acetylation of HIV Tat by p300 as well as virus proliferation

HIV/AIDS Therapy - Highly potent HIV entry inhibitors developed