Anti-Inflammatory Therapy
Modulation of iron metabolism a potential approach for anti-inflammatory therapy
Published in Hematology Week, February 21st, 2005
According to a study from the United States, "During inflammation, NF-kappaB transcription factors antagonize apoptosis induced by tumor necrosis factor (TNF)alpha.
"This antiapoptotic activity of NF-kappaB involves suppressing the accumulation of reactive oxygen species (ROS) and controlling the activation of the c-Jun N-terminal kinase (JNK) cascade. However, the mechanism(s) by which NF-kappaB inhibits ROS accumulation is unclear."
"We identify ferritin heavy chain (FHC)-the primary iron storage factor-as an essential mediator of the...
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Source: Hematology Week (2005-02-21)
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