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Resveratrol

Toxicity from resveratrol seen only at the highest dose tested

Published in Hematology Week, February 21st, 2005

Toxicity from resveratrol was seen only at the highest dose tested.

"Resveratrol, (3,5,4'-trihydoxystilbene) a compound found in grapes, mulberries, and peanuts, has antimycotic, antiviral, and beneficial cardiovascular and cancer preventive activities. It is being developed for several clinical indications.

"To evaluate the potential toxicity of resveratrol, rats were administered by gavage 0, 300, 1000, and 3000 mg trans-resveratrol per kilogram body weight per day for 4 weeks," wrote investigators in the United States,

"Most of the adverse events occurred in the rats administered 3000 mg per kilogram body weight per day.

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