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Liposomal Delivery

Liposome-encapsulated prolidase studied, role as delivery system assessed

Published in Hematology Week, April 4th, 2005

A study from Italy has explored the intracellular delivery of liposome-encapsulated prolidase in cultured fibroblasts.

"Prolidase is a cytosolic exopeptidase whose deficiency causes the development of a rare autosomal recessive disorder known as Prolidase Deficiency (PD). The main manifestations of PD are intractable ulcerations of the skin, recurrent infections and mental retardation. At this time only a hazardous and expensive chronic therapy based on blood transfusions is the suggested treatment for PD.

"The aim of this work was to investigate the capability of utilizing liposomes as enzyme carriers: these vesicular systems have been recently...

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