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Ischemia

Fibrin-derived peptide B beta(15-42) studied, myocardial protection noted

Published in Hematology Week, May 2nd, 2005

According to a study from Germany, the fibrin-derived peptide B beta(15-42) protects the myocardium against ischemia-reperfusion injury.

"In the event of a myocardial infarction, current interventions aim to reopen the occluded vessel to reduce myocardial damage and injury. Although reperfusion is essential for tissue salvage, it can cause further damage and the onset of inflammation," wrote P. Petzelbauer and colleagues, University Hospital of Dusseldorf.

"We show a novel anti-inflammatory effect of a fibrin-derived peptide, B beta(15-42). This peptide competes with the fibrin fragment N-terminal disulfide knot-II (an analog of the fibrin E1...

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