Hematology Week

Acute Lymphoblastic Leukemia - RAS mutation associated with hyperdiploidy/parental characteristics in ALL

Bacterial Diagnostics - Microbial typing system characterizes S. aureus strains faster than PFGE

Bladder Cancer - Drinking water improvement reduced bladder cancer mortality in high arsenic area

Lung Cancer - SPLUNC1 may be useful marker for lung cancer

Pancreatic Cancer - Dietary intake of lycopene associated with reduced pancreatic cancer risk

Abdominal Surgery - Transarterial embolization effective for postoperative hemorrhage

Acute Lymphocytic Leukemia - Radiation-related ALL via pre-existing clonally expanded preleukemic cells

Acute Myeloid Leukemia - CEBP alpha gene mutations occur in 6% of childhood acute myeloid leukemia

Acute Myeloid Leukemia - Pericentric chromosome 8 inversion associated with 5'RUNX1/3'CBFA2T1 gene in AML

Acute Peripheral Arterial Occlusion - Enrollment begins in phase 3 trial of alfimeprase

Adenovirus Infection - Oculopathogenic adenoviruses identified by fiber/hexon gene amplification

Oncology - Researchers describe findings in oncology studies

Anthrax - Anthrax antigen and toxin receptor studied, molecular dynamics clarified

Antibiotic Resistance - Antibiotic resistance transmission rates/prevalence higher in urban hospitals

Antimicrobials - Altered pharmacokinetics in the elderly make antimicrobial dosing difficult

Apoptosis - CAPE may act as scavenger of free radicals to prevent apoptotic effect of I/R

Beta Amyloid - Beta-amyloid analyzed, role in neuroblastoma cells detachment clarified

Biosensors - Carbon nanotube-modified biosensor used to monitor total cholesterol in blood

Blood Donation - Threshold for becoming a blood donor in Norway is high

Bone Marrow - Murine permeability-increasing protein ortholog studied, locations shown

Bone Regeneration - Bioactive glasses influence bone marrow stromal cell differentiation

Business & Finance - Cell therapy company provides research and financial update

Campylobacter - Sources other than chickens important in human campylobacteriosis

Cancer Immunotherapy - Coexpressed ligands stimulate anti-leukemia cell immunity

Cancer Research - Accrual to phase 2 trial acute myeloid leukemia, high-risk MDS drug closed

Cancer Therapy - Efficacy of telomerase inhibitor drug discussed at AACR annual meeting

Cancer Therapy - Phase I-II trial of ABIO 05/01 begins in peritoneal carcinosis patients

Cholestasis - Cholestasis studied, role of tight-junction-associated proteins clarified

Chronic Lymphocytic Leukemia - Phase I trial for CHIR-12.12 for CLL begins

Chronic Myelogenous Leukemia - P210(BCR/ABL) suppresses cell adhesion/motility gene expression in CML

Chronic Myeloid Leukemia - Telomerase activity may not be elevated on a cell-to-cell basis in CML

Collaborations - Biotech company signs contract with South African National Blood Service

Congenital Tuberculosis - Congenital tuberculosis nosocomially transmitted in neonatal ICU

Corticosteroid - Corticosteroids frequently mask inflammatory reactions in ASCT recipients

Coxsackievirus Outbreak - Coxsackievirus A24 variant outbreak rapidly identified by molecular serotyping

Cryptococcosis - Pulmonary cryptococcosis/nonsmall cell lung cancer in ICL/non-HIV patient

Cryptosporidiosis - Nested PCR and RFLP detects Cryptosporidium/identifies to species level

Dengue Fever - Approximately 1/2 suspected dengue outbreak infections confirmed IgM Ab positive

Diagnostics - CNS leukemia detected in children with acute lymphoblastic leukemia

Diagnostics - Hematology analyzer used to test cyclists for blood doping, erythropoietin abuse

Diagnostics - Leukocyte HLA-B*420502 allele identified by HLA typing and subsequent sequencing

Diagnostics - Study: Fetal erythroblast isn't best target for noninvasive prenatal diagnosis

Diagnostics - Using NRBCs to determine fetal gender and hemophilia A status is questionable

Disease Associations - Regulation of Hfe by stress factors in BV-2 cells

Donor Lymphocyte Infusion - Outcome established in relapsed HSCT patients given donor lymphocyte infusions

Drug Delivery - Hydrogels from oxidized alginate/gelatin are injectable for tissue engineering

Drug Development - Australian regulatory approval granted for Advate to treat hemophilia A

Drug Development - Phase III study evaluating Trasylol during hip replacement surgery

Embryonic Stem Cell Research - Lecithinized brain-derived neurotrophic factor promotes ESC differentiation

Endothelin - Myocyte behavior during sepsis studied, role of signaling revealed

Extended-Spectrum Beta-Lactamase Diagnostics - Four commercially available ESBL phenotypic confirmation tests comparable

Fetal Chemical Exposure - Umbilical cord is best sample choice to assess fetal chemical exposure

Finance - Biotechnology company reports 2005 fiscal first quarter financial results

Food Poisoning - Food poisoning outbreak caused by contaminated milk powder

Gastrointestinal Stromal Tumor - PKC theta useful marker for identifying KIT-negative tumors

Gene Silencing - Lentiviral vectors encoding short hairpin RNA stop primary effusion lymphomas

HIV/AIDS Diagnostics - Neutralizing/nonneutralizing IgG captures HIV-1 via antibodies against gp41

HIV/AIDS Drug Development - High-mannose sugar-binding proteins may be used to control HIV infection

HIV/AIDS Drug Development - Topological models predict anti-HIV activity of S-DABO analogues

HIV/AIDS Epidemiology - HIV non-B subtypes circulating in Italy

HIV/AIDS Epidemiology - Two-sample tests compare intraindividual genetic diversity in HIV infection

HIV/AIDS Pathogenesis - FCP1 required for HIV-1 Tat-mediated transactivation

HIV/AIDS Pathogenesis - HIV-1 Tat N-terminus essential for Tat-TAR RNA interaction

HIV/AIDS Pathogenesis - HIV-1-associated uracil DNA glycosylase activity essential to HIV-1 life cycle

HIV/AIDS Pathogenesis - SPRY protein domain "patch" essential for retroviral restriction

HIV/AIDS Research - KIR epitope expression may influence NK-mediated immune response in HIV/AIDS

HIV/AIDS Research - Studies add new findings to HIV/AIDS body of knowledge

HIV/AIDS Tuberculosis Coinfection - HIV/TB patients have difficulty accessing ART outside Malawi hospital setting

HIV/AIDS Vaccine - Vaccine developed against Chinese HIV-1 subtype C

Hairy Cell Leukemia - Immunohistochemical DBA.44/TRAP expression useful in diagnosis

Heart Surgery - Novel ECC device prevents immune hyperactivation with anti-Fas antibodies

Hematology - Antiangiogenic gene therapy halts hematological malignancy in mice

Hematology - Factor IX variants extend the potential of hemophilia B gene therapy

Hematology - Systemic hypoxia affects proangiogenic cytokine in patients with solid tumors

Hematopoiesis - Cyclic ADP-ribose uptake by BST-1⁺ stroma stimulates hematopoiesis

Hematopoietic Stem Cell Research - Multiple classes of hematopoietic CD34+ cells differ greatly in telomere length

Hemophilia A - Full-length sucrose-formulated recombinant FVIII effective for young children

Hemorrhagic Conjunctivitis Outbreaks - Hemorrhagic conjunctivitis outbreak caused by coxsackievirus A24 variant

Heparin - Low-molecular-weight heparin used for secondary prophylaxis of thromboembolism

Hepatitis C Treatment - Final analyses of drug for chronic hepatitis C in phase 2 trial presented

Hepatocyte Bioreactor - Perfused hepatocyte bioreactor produces in vitro model of zonation

Human T Cell Leukemia Virus Type 1 - HTLV-I Tax activates CD40 gene expression via the NF-kappa B pathway

Hypertension - Low estrogen levels differentially affect rats' blood pressure depending on age

Immunology - Utility of protein arrays for blood cells reviewed

Infection Spread - Air travel has important role in rapid spread of newly emerging infections

Influenza Pandemic - Genome reassortment of avian/human influenza virus may generate pandemic viruses

Influenza Pandemic - Oseltamivir has potential use in influenza pandemic if used responsibly

Ischemia - Focal cerebral ischemia examined, evolution of GADD34 expression shown

Ischemia - Hypothermia analyzed, long-term neuronal effects clarified

Ischemia - Ischemic brain injury examined, protective role of fusion protein revealed

Ischemia - Longer ischemias may inhibit vasoconstriction and reduce nitric oxide production

Ischemia - Transient cerebral ischemia studied, effects on mitochondria clarified