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Gastric Cancer

 H. pylori+enhanced mucosal IL-1beta production increases gastric cancer risk

Published in Hematology Week, May 30th, 2005

Helicobacter pylori infection and enhanced mucosal IL-1beta production increases the risk for developing gastric.

"Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians.

"We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1beta and an increased risk of developing GC in a Korean population," investigators in South Korea report.

"Polymorphisms of IL-1A-889,...

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