HIV/AIDS Pathogenesis
HIV CCR5/CXCR4 upregulation partially contribute to YY1 downregulation
Published in Hematology Week, May 30th, 2005
"We have found previously that the chemokine receptors CCR5 and CXCR4, which are the coreceptors of HIV, are upregulated in human macrophage cell line U937 infected by Mycobacterium tuberculosis (MTB). This suggests another possibility to explain the coinfection of MTB and HIV.
"In order to detect the upregulation of CCR5 and CXCR4 as a unique phenomenon of MTB infection or a ubiquitous phenomenon of pathogenic bacteria, we investigated the expression changes of these two chemokine receptors in macrophages attacked by another bacterium Actinobacillus...
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Source: Hematology Week (2005-05-30)
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