HIV/AIDS Therapy

Research add new data to HIV/AIDS therapy body of knowledge

Published in Hematology Week, May 30th, 2005

New findings from the United States and Belgium describe advances in HIV/AIDS therapy.

Study 1: NNRTIs and RNase H inhibitors given in the same HAART regimen may be therapeutically beneficial.

"Although HIV-1 reverse transcriptase (RT) DNA polymerase and ribonuclease H (RNase H) activities reside in spatially distinct domains of the enzyme, inhibitors that bind in the RT polymerase domain can affect RNase H activity.

"We used both gel assays and a real-time FRET assay to analyze the impact of three mechanistically distinct RT polymerase inhibitors on RNase H activity in vitro," investigators in the United States report.

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Source: Hematology Week (2005-05-30)

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