Published in Hematology Week, May 30th, 2005
Study 1: NNRTIs and RNase H inhibitors given in the same HAART regimen may be therapeutically beneficial.
"Although HIV-1 reverse transcriptase (RT) DNA polymerase and ribonuclease H (RNase H) activities reside in spatially distinct domains of the enzyme, inhibitors that bind in the RT polymerase domain can affect RNase H activity.
"We used both gel assays and a real-time FRET assay to analyze the impact of three mechanistically distinct RT polymerase inhibitors on RNase H activity in vitro," investigators in the United States report.
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