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Lung Cancer

 M. tuberculosis infection associated with FHIT gene LOH in lung cancer

Published in Hematology Week, June 13th, 2005

Mycobacterium tuberculosis infection is associated with the FHIT gene LOH in lung cancer.

"Although it is fairly well accepted that pulmonary tuberculosis is a major risk factor of lung cancer, the exact molecular mechanisms involved in its tumorigenesis are unclear.

"For this purpose, we have examined the relationship between Mycobacterium tuberculosis (M-TB) infection and FHIT gene alteration in lung cancer," scientists in China report.

"Tumors with M-TB infection had a slightly higher abnormal FHIT protein expression compared with tumors without M-TB infection, although not statistically significant (Fisher's...

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