Susan Hasty, Publisher
Table of Contents . . . July 18th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Hematology Week | Other Publications
Bioartificial Liver - Small radial flow bioreactor constructs highly functional artificial liver
Human Herpesviruses - Valacyclovir decreases EBV prevalence in saliva but not HHV-6 and HHV-7
Mercury Poisoning - Loss of IQ due to mercury poisoning is economic productivity loss to U.S.
Prostate Cancer - Sca-1-enriched prostate-regenerating cells can initiate prostate tumorigenesis
Stem Cell Transplantation - Clinical sequelae following microbially-contaminated SC infusions are rare
AIDS-Related Kaposi Sarcoma - Docetaxel rapidly effective in anthracycline-pretreated AIDS-related KS patients
Acinetobacter Baumannii - Imipenem-resistant A. baumannii outbreak produced OXA-23 beta-lactamase
Actin - Actin cytoskeleton studied, differential platelet regulation revealed
Acute Vertebrobasilar Occlusion - IV Abciximab, intra-arterial rtPA, and additional PTA/stenting improve outcome
Adverse Drug Reaction - Epoetin alfa for reversing drug-related anemia causes pure red cell aplasia
Anesthesia - High thoracic epidural anesthesia improved diastolic LV function in CAD patients
Angiology - New data illuminates research in angiology
Aneurysm - Extracranial carotid artery aneurysms can be managed with good results
Angiology - Atenolol or lacidipine treatment was accompanied by decrease in LV mass
Angiology - Endovascular abdominal aortic aneurysm repair
Angiology - Findings advance knowledge in angiology research
Angiology - Knowledge of IJV anatomy may reduce the chance of laceration
Angiology - Researchers report details of new studies and findings in the area of angiology
Angiology - One-third of patients unsuitable for stenting, largely due to carotid anatomy
Angiology - U.S. trial for atrial fibrillation underway
Angioplasty - P2Y12H2 haplotype does not affect platelet response to clopidogrel
Angiology - Studies advance knowledge in angiology research
Angioplasty - Study reports positive results of angioplasty in at-risk region
Angiotensin - Review discusses the role of Ang-(1-7) in the heart and blood vessels
Anopheles - Deforestation facilitates survival of immature stage of Anopheles gambiae
Anti-inflammatory Medicine - Adenosine involved in anti-inflammatory action of ketamine
Antimicrobial Drug Adherence - Pharmionics measures patient adherence to prescribed antimicrobial drug regimens
Aortic Trauma - Endovascular treatment of descending aorta trauma effective
Aspergillosis - Itraconazole did not improve outcome of invasive aspergillosis
HIV/AIDS Pathogenesis - Reports advance knowledge in HIV/AIDS pathogenesis research
Aspergillosis - Scoring system developed to help predict risk of invasive aspergillosis
Atherosclerosis - New findings in the area of atherosclerosis detailed
Avian Influenza - Researchers describe findings in avian influenza studies
Bacterial Vaginosis - TNF-alpha secretion/TLR4 mRNA expression stimulated in bacterial vaginosis
Bioartificial Liver - Collagen coating improves biocompatibility of membranes for hepatocyte culture
Bladder Cancer - Cox-2 & Her2/neu coexpression status not a bladder cancer prognostic indicator
HIV/AIDS Pathogenesis - Studies describe new findings in HIV/AIDS pathogenesis research
Blood Safety - Pathogen inactivation proactively protects the blood supply
Bone Fractures - Bone fracture repair analyzed, role of bone marrow-derived cells defined
Brain Aneurysms - New stent procedure for minimally invasive of brain aneurysms announced
Breast Cancer - LAF-4 aberrantly expressed in human breast cancer
Breast Cancer - Treatment regimen associated with higher incidence of febrile neutropenia
Burkholderia Pseudomallei - Schema developed for laboratory identification of Burkholderia pseudomallei
Business Update - Biological products company announces accelerated integration program
Business Update - Device company completes $8.3 million series B financing
Business Update - Japan-based drug developer awards $1.6 million to collect cardiac safety data
Cachexia - Melanocortin-4 receptor antagonist attenuates cachexia/preserves lean body mass
Cancer Therapy - Pancratistatin initiates rapid apoptosis in human lymphoma cells
Cancer Therapy - U.S. FDA grants fast track status for Fodosine in refractory T-cell leukemia
Cardiac Risk Assessment - Wider use of analysis technique might strengthen evidence base for interventions
Cardiology - CABG and PTCA produce improvement in health-related quality of life
Cardiology - Cardiovascular disease experts urge practice of comprehensive CV risk management
Cardiology - Data advance knowledge in cardiology research
Cardiology - Destination therapy implant of artificial hearts in 2 European patients reported
Cardiopulmonary Bypass - Origin of perioperative neuronal-ischemic markers clarified
Cardiovascular Disease - Induced uremia has a permissive effect for CV damage
Cardiovascular Disease - Measurement of Lp-PLA2 may identify individuals at risk for cardiac events
Cardiovascular Disease - Review relates mitochondrial damage to CV disease risk factors and development
Carotid Artery Occlusion - Integrated MR method shows hemodynamic compromise
Cerebral Hemorrhage - Inflammation occurred in brain after experimental subarachnoid hemorrhage
Cervicocerebral Arterial Dissection - Etiology, diagnosis and treatment reviewed
Circadian Rhythm - Study evaluated rate changes of activated factor X, thrombin generation
Coagulation - Researchers' work adds to coagulation body of knowledge
Collaborations - Reagent maker, Kainos agree to form joint venture
Collaborations - Vitae enters alliance to develop and commercialize hypertension treatment
Coronary Artery Calcification - Social network indices are associated with coronary artery calcification
Coronary Artery Disease - Case Method Learning-supported lipid-lowering strategy is cost-effective
Coronary Artery Disease - High resting heart rate is a predictor for total and cardiovascular mortality
Coronary Artery Disease - Optimized pharmacological therapy can improve prognosis of CAD patients
Cytomegalovirus - Integrin alphavbeta3 is a coreceptor for human cytomegalovirus
Dengue Epidemic - Anticipating emergence/preventing spread reduces effects of dengue epidemics
Dengue Fever - Ultrasound assists in diagnosis of dengue fever
Dextran Sulfate - Dextran sulfate may interfere with leukocyte-endothelial cell adhesion
Diabetes Control - Pager-sized monitor for diabetes control receives FDA clearance
Diagnostics - U.S. FDA grants 510(k) clearance for blood screening controls
Diagnostics - U.S. FDA grants clearance for immunoassay for diagnosing venous thrombembolism
Diet & Nutrition - High-energy intake provides folate intake necessary for tHcy decrease
Diet & Nutrition - Vitamin deficiencies may aggravate the risk of coronary artery disease.
Dilated Cardiomyopathy - Blood flow responses imply signaling defects or structural anomalies
Drug Development - CXR Biosciences collaboration to establish drug screening platform initiated
Drug Development - Microfluidic device detects agonist-induced platelet calcium flux
Echocardiography - Positive stress ECG is a valid method for testing high-risk patients for CAD
Electrocardiography - Dipyridamole-stress SAECG easily detects CAD and myocardial ischemia at bedside
Embryonic Stem Cell Research - BMP signaling inhibition by Noggin induces cardiomyocyte ESC differentiation
Embryonic Stem Cell Research - Embryonic stem cell lines derived on serum-free placental fibroblasts
End-Stage Renal Disease - Lanthanum carbonate suitable for use during hemodialysis
Epstein-Barr Virus - Phenotype and frequency of Epstein-Barr virus-infected cells determined
Erythropoiesis - Kell and XK transcripts occur early during erythropoiesis
Etiology - Genetic analysis of common diseases in postmenopausal women is funded
Finance - Medical device company prices IPO of common stock at $14 per share
Follicular Cancer - Follicular thyroid carcinoma distinguished from adenoma
Genetics & Genomics - FGF2 expression cannot be referred to as an independent clinical marker for CAD
HIV/AIDS Coinfection - HIV-specific cytolysis/increased IL-10 associated w/ S. mansoni coinfection
HIV/AIDS Dementia - HIV-induced alterations in CNS converge at neuronal p53 activation
HIV/AIDS Drug Development - Cycloamide-derived HIV protease inhibitors have antiretroviral activity
HIV/AIDS Drug Development - Ginsenosides block ritonavir-induced vascular dysfunction of coronary arteries
HIV/AIDS Drug Development - IL-4 antisense DNA inhibits pathogenic simian HIV replication in macaques
HIV/AIDS Drug Effect - Endoplasmic reticulum stress linked to protease inhibitor-related dyslipidemia
HIV/AIDS Drug Resistance - Mutations not associated with primary antiretroviral resistance in Chili
HIV/AIDS Drug Side Effect - Intracellular cytokines may model abacavir hypersensitivity immunoregulation
HIV/AIDS Epidemiology - Mathematical models make qualitative predictions about spread of HIV over time
HIV/AIDS Epidemiology - Mutagenetic trees describe accumulation of HAART-induced HIV mutations
HIV/AIDS Lipodystrophy - Lipodystrophy severity impacts negatively on body image of HIV-infected patients
HIV/AIDS Lipodystrophy - Risk factors identified for fat atrophy & fat deposition development in HIV/AIDS
HIV/AIDS Pain Management - Pain has substantial impact on physical performance and QOL among HIV patients
HIV/AIDS Pathogenesis - Findings describe new data in HIV/AIDS pathogenesis research
HIV/AIDS Pathogenesis - Fusion activity of HIV-1 gp41 depends on interhelical interactions
HIV/AIDS Pathogenesis - P53 is a proapoptotic signal transducer involved in AIDS
HIV/AIDS Prognostics - HIV-1-specific CD4 cell responses+IgG2 Ab predicts long-term nonprogression
HIV/AIDS Wasting - NRTI is main determinant of mtDNA depletion in adipose tissue of HIV patients
HIV/AIDS-Related Infection - Invasive S. pneumoniae infections declining in HAART era
Heart Disease - Association of H. pylori infection and ischemic HD remains debatable
Heart Disease - Pharma company begins manufacturing torcetrapib/atorvastatin calcium
Helicobacter Pylori - Probiotics improves tolerance to Helicobacter pylori eradication therapy
Hematology - Cell type and developmental stage guide the efficacy of RNA interference
Hematology - Reports add new data to hematology research
Hematopoiesis - PIG-A mutations occur in differentiated progenitors rather than HSCs
Hemodialysis - Silent cerebral infarction is risk factor for vascular events in renal patients
Hemoglobin - Alpha-hemoglobin structure studied, protective mechanism for heme revealed
Hemoglobin - O-raffinose crosslinked hemoglobin lacks site-specificity in cavity
Hepatitis B Virus - Occult hepatitis B is uncommon among dialysis patients in Italy
Homocysteine - Review focuses on the role of homocysteine in development of heart disease
Human Papillomavirus - HPV-directed cell-mediated immune response plays role in wart resolution
Hypoxia - Hypoxia studied, protective role of vitamin C defined
Imaging - Recent studies add new data to imaging research
Inhibitory Factors - Leukemia inhibitory factor blocked early differentiation of skeletal muscle
Intracranial Atherosclerosis - Study determines factors associated with occult coronary artery disease
Ischemia - Forebrain ischemia studied, receptor-tyrosine kinase interactions revealed
Ischemia - New findings in the area of ischemia described
Legal Issues - U.S. District Court jury finds patents infringed by Boston Scientific stents
Legionella Pneumophila - Sequence-based L. pneumophila typing concordant and discriminatory
Leukapheresis - Magnesium supplementation does not reduce side effects of leukapheresis
Leukemia - Conserved molecular signatures found in leukemia
Leukemia - Leukemogenesis linked to covalent modifications of chromatin
Lipoproteins - Coadministration of EZE with ATV led to greater reductions in LDL-C
Liposomes - Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells found
Listeria Monocytogenes - Cell-to-cell spread facilitates L. monocytogenes mom-to-fetal transmission
Liver Cancer - Reports advance knowledge in liver cancer research
Liver Transplants - Hepatic transit time indicated therapeutic response to radiofrequency ablation
Liver Transplants - Interventional radiology advised for liver transplantation
Liver Transplants - Liver transplant outcomes for hepatocellular carcinoma reviewed
Liver Transplants - Recommendations for surgical treatment of hepatoblastoma outlined
Lung Cancer - Researchers find lung cancer may begin in newly isolated lung stem cells
Malaria - Babies born from malaria-infected mothers susceptible to malaria early in life
Malaria - Further studies needed to determine accuracy of rapid malaria diagnostic tests
Medical Devices - Medical device company receives FDA approval for its high flux filter
Multiple Myeloma - Azaspirane hinders cancer proliferation factors in the bone marrow environment
Multiple Myeloma - Celgene's Revlimid: $321M in sales for multiple myeloma drug market in 2009
Mycobacterium Avium - M. avium enters state of metabolic dormancy in response to starvation
Mycobacterium Tuberculosis - M. avium subsp. paratuberculosis rapidly detected/typed from broth cultures
Mycobacterium Tuberculosis - HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis
Mycobacterium Tuberculosis - Immunity to infection with Mycobacterium tuberculosis is influenced by age
Mycobacterium Tuberculosis - Transmembrane TNF provides acute control of M. tuberculosis infection
Mycobacterium Tuberculosis - W-Beijing MTB strains identified with targeted IS6110 fingerprints hybridization
Myelodysplastic Syndromes - U.S. FDA grants priority review for REVLIMID
Myeloma - Erk5 analyzed multifunctional role in multiple myeloma defined
Myeloma - International Staging System for multiple myeloma developed
Neural Stem Cell Research - Allopregnanolone promotes neural progenitor cell proliferation
Neural Stem Cell Research - BM-derived MSCs and CD90+ cells express neuroglial transcripts in culture
Neural Stem Cell Research - Neural stem cells may be beneficial to maintaining a normal striatal environment
Neural Stem Cell Research - Neural turnover in vomeronasal epithelium occurs through vertical migration
Neural Stem Cell Research - Neurogenesis diminishes with age
Neural Stem Cell Research - Xenopus Id3 required downstream of Myc for multipotent neural crest SC formation
Neutrophils - Neutrophil platelet-activating factor studied, stress-induced synthesis shown
Nocardiosis - Underlying diseases common in patients with nocardiosis
Nonpromyelocytic Acute Myeloid Leukemia - FLT3 mutation is adverse prognostic factor in nonpromyelocytic AML after SCT
Obstetrics - Pomegranate juice for moms may help babies resist brain injury
Obstetrics - Researchers publish new studies and findings in the area of obstetrics
Omega 3 Fatty Acids - Report describes potential for omega-3 fatty acids to prevent CV conditions
Oncology - Raf signals drive VEGF in Kaposi sarcoma-associated herpesvirus-infected cells
Pain Management - Company announces clinical trial for treatment of critical limb ischemia
Pathogenesis - Calcification inhibitors studied, role in kidney vascular calcification defined
Percutaneous Coronary Intervention - Full antiplatelet effect of 600 mg of clopidogrel is achieved after 2 hours
Personnel - Farallon Medical appoints Dr. Lee Carmack to vice president of development
Personnel - Hematologist Pierre Laneuville, MD, named to cryogenics company advisory board
Plasmodium Falciparum - Transfected erythrocytes studied, virulence factor trafficking clarified
Poliovirus - Cloning system mass produces virus-binding protein specific for poliovirus-1
Prostate Cancer - Statins should be tested as adjuvant therapy in prostate cancer trials
Pseudomonas Aeruginosa - Mab against P. aeruginosa protective against fatal pseudomonas sepsis
Pseudomonas Aeruginosa - Substance P regulates NK cell IFN-gamma production/resist to P. aeruginosa
RNA Research - MicroRNA expression in mouse stem cells study presented at conference
Respiratory Syncytial Virus - Group A RSV isolates from Argentina have more genetic variability than group B
Rotavirus Gastroenteritis - G9 is predominant genotype in pediatric rotavirus gastroenteritis in Belgium
SARS Coronavirus - Rolling circle amplification test rapid/sensitive for SARS coronavirus detection
Saccharomyces Cerevisiae - Saccharomyces cerevisiae fungemia is an emerging infectious disease
Scleroderma - Skewed X chromosome inactivation mosaicism may play pathogenic role in women
Sepsis Therapy - YC-1 blocks proinflammatory cytokine production in mice
Staphylococcus Aureus - S. aureus Panton-Valentine leucocidin+ isolates from diverse backgrounds
Statins - Atorvastatin treatment improved atherogenic lipoprotein profile in acromegaly
Stem Cell Blood Banking - Umbilical cord blood banks for transplantation differ in levels of quality
Stem Cell Research - Auditory nerve has capability for self-renewal and replacement
Stem Cell Research - CD34 microbeads used as magnetic cell label for in vivo cell visualization
Stem Cell Research - M-CSF drives differentiation of monocytes into anti-inflammatory M-DCs
Stem Cell Research - Mesenchymal stem cells inhibit differentiation/function of monocyte-derived DCs
Stem Cell Research - Mesenchymal stem cells remain of host origin long after APBSCT or BMT
Stem Cell Research - Microarray sheds slight on aberrant genes in agnogenic myeloid metaplasia
Stem Cell Research - Multipotent adipose-derived SCs are future tool for muscle cell-mediated therapy
Stem Cell Research - Ocular surface cells contain ABCG2-dependent SP cells with stem cell features
Stem Cell Research - PI-MECs are cellular targets for pregnancy-enhanced mammary tumorigenesis
Stem Cell Research - Scientists develop new technology to grow blood cells from embryonic stem cells
Stem Cell Research - Serum free T cell medium for expansion, activation of human T cells introduced
Stem Cell Research - Stem cell quiescence & SC pool maintenance not dependent on TGF-beta signaling
Stem Cell Research - Stromal-derived factor-1 promotes BM stromal SC growth/survival/development
Stem Cell Research - Systematic gene perturbation in planaria identifies genes for SC function
Stem Cell Research - Thrombopoietin initiates GP6 transcription during megakaryocyte differentiation
Stem Cell Research - Umbilical cord blood cells express neurotrophic factors
Stem Cell Research - WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action
Stem Cell Therapy - Phase I clinical trials promising for stem-cell-based cardiac therapy
Stem Cell Transplantation - Mismatched-related cells are a viable therapy for patients with acute leukemia
Stem Cell Transplantation - T-cell chimerism molecular monitoring early after SCT predicts GVHD grades II-IV
Stem Cell Transplantation - Vestibulocochlear nerve supports fetal dorsal root ganlion xenotranplant
Stem Cells & Aging - Aging affects hematopoietic stem cells guidance toward the B-cell pathway
Stents - Data advance knowledge in stents research
Stents - Vivant Z stent was safe and efficacious in de novo coronary artery lesions
Systemic Lupus Erythematosus - SLE patients have a high prevalence of early carotid atherosclerosis
Thrombosis - Resection of jugular vein necessitated by radical neck dissection
Tissue Engineering - Condyle with chondral & osseous components derived from single SC population
Tissue Engineering - Porosity choice of 3D biomaterial scaffolds affects progression of osteogenesis
Toxicology - Shiga toxin studied, up-regulation of tissue factor activity described
Transfusion Medicine - New transfusion technology reduces pathogen transmission
Transfusion Medicine - U.S. FDA grants priority review for Exjade for chronic iron overload
Transplant Medicine - In utero bone marrow transplantation in swine mitigates kidney graft rejection
Tuberculosis - Children require higher INH dose to achieve concentrations comparable to adults
Tuberculosis - Gestational multidrug-resistant tuberculosis therapy not toxic among children
Tuberculosis - High-resolution CT detects activity of suspected smear negative pulmonary TB
Tumor Distribution - Different pneumoperitoneal pressures influenced tumor cell distribution in rats
Umbilical Cord Blood Banking - Semiautomated RBC depletion system saves time/improves cell recovery
Varicella Zoster Virus - VZV reactivates following discontinuation of aciclovir prophylaxis for HSCT
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