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Hematology Week

Susan Hasty, Publisher

Table of Contents . . . July 18th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Hematology Week | Other Publications

Bioartificial Liver - Small radial flow bioreactor constructs highly functional artificial liver

Human Herpesviruses - Valacyclovir decreases EBV prevalence in saliva but not HHV-6 and HHV-7

Mercury Poisoning - Loss of IQ due to mercury poisoning is economic productivity loss to U.S.

Prostate Cancer - Sca-1-enriched prostate-regenerating cells can initiate prostate tumorigenesis

Stem Cell Transplantation - Clinical sequelae following microbially-contaminated SC infusions are rare

AIDS-Related Kaposi Sarcoma - Docetaxel rapidly effective in anthracycline-pretreated AIDS-related KS patients

Acinetobacter Baumannii - Imipenem-resistant A. baumannii outbreak produced OXA-23 beta-lactamase

Actin - Actin cytoskeleton studied, differential platelet regulation revealed

Acute Vertebrobasilar Occlusion - IV Abciximab, intra-arterial rtPA, and additional PTA/stenting improve outcome

Adverse Drug Reaction - Epoetin alfa for reversing drug-related anemia causes pure red cell aplasia

Anesthesia - High thoracic epidural anesthesia improved diastolic LV function in CAD patients

Angiology - New data illuminates research in angiology

Aneurysm - Extracranial carotid artery aneurysms can be managed with good results

Angiology - Atenolol or lacidipine treatment was accompanied by decrease in LV mass

Angiology - Endovascular abdominal aortic aneurysm repair

Angiology - Findings advance knowledge in angiology research

Angiology - Knowledge of IJV anatomy may reduce the chance of laceration

Angiology - Researchers report details of new studies and findings in the area of angiology

Angiology - One-third of patients unsuitable for stenting, largely due to carotid anatomy

Angiology - U.S. trial for atrial fibrillation underway

Angioplasty - P2Y12H2 haplotype does not affect platelet response to clopidogrel

Angiology - Studies advance knowledge in angiology research

Angioplasty - Study reports positive results of angioplasty in at-risk region

Angiotensin - Review discusses the role of Ang-(1-7) in the heart and blood vessels

Anopheles - Deforestation facilitates survival of immature stage of Anopheles gambiae

Anti-inflammatory Medicine - Adenosine involved in anti-inflammatory action of ketamine

Antimicrobial Drug Adherence - Pharmionics measures patient adherence to prescribed antimicrobial drug regimens

Aortic Trauma - Endovascular treatment of descending aorta trauma effective

Aspergillosis - Itraconazole did not improve outcome of invasive aspergillosis

HIV/AIDS Pathogenesis - Reports advance knowledge in HIV/AIDS pathogenesis research

Aspergillosis - Scoring system developed to help predict risk of invasive aspergillosis

Atherosclerosis - New findings in the area of atherosclerosis detailed

Avian Influenza - Researchers describe findings in avian influenza studies

Bacterial Vaginosis - TNF-alpha secretion/TLR4 mRNA expression stimulated in bacterial vaginosis

Bioartificial Liver - Collagen coating improves biocompatibility of membranes for hepatocyte culture

Bladder Cancer - Cox-2 & Her2/neu coexpression status not a bladder cancer prognostic indicator

HIV/AIDS Pathogenesis - Studies describe new findings in HIV/AIDS pathogenesis research

Blood Safety - Pathogen inactivation proactively protects the blood supply

Bone Fractures - Bone fracture repair analyzed, role of bone marrow-derived cells defined

Brain Aneurysms - New stent procedure for minimally invasive of brain aneurysms announced

Breast Cancer - LAF-4 aberrantly expressed in human breast cancer

Breast Cancer - Treatment regimen associated with higher incidence of febrile neutropenia

Burkholderia Pseudomallei - Schema developed for laboratory identification of Burkholderia pseudomallei

Business Update - Biological products company announces accelerated integration program

Business Update - Device company completes $8.3 million series B financing

Business Update - Japan-based drug developer awards $1.6 million to collect cardiac safety data

Cachexia - Melanocortin-4 receptor antagonist attenuates cachexia/preserves lean body mass

Cancer Therapy - Pancratistatin initiates rapid apoptosis in human lymphoma cells

Cancer Therapy - U.S. FDA grants fast track status for Fodosine in refractory T-cell leukemia

Cardiac Risk Assessment - Wider use of analysis technique might strengthen evidence base for interventions

Cardiology - CABG and PTCA produce improvement in health-related quality of life

Cardiology - Cardiovascular disease experts urge practice of comprehensive CV risk management

Cardiology - Data advance knowledge in cardiology research

Cardiology - Destination therapy implant of artificial hearts in 2 European patients reported

Cardiopulmonary Bypass - Origin of perioperative neuronal-ischemic markers clarified

Cardiovascular Disease - Induced uremia has a permissive effect for CV damage

Cardiovascular Disease - Measurement of Lp-PLA2 may identify individuals at risk for cardiac events

Cardiovascular Disease - Review relates mitochondrial damage to CV disease risk factors and development

Carotid Artery Occlusion - Integrated MR method shows hemodynamic compromise

Cerebral Hemorrhage - Inflammation occurred in brain after experimental subarachnoid hemorrhage

Cervicocerebral Arterial Dissection - Etiology, diagnosis and treatment reviewed

Circadian Rhythm - Study evaluated rate changes of activated factor X, thrombin generation

Coagulation - Researchers' work adds to coagulation body of knowledge

Collaborations - Reagent maker, Kainos agree to form joint venture

Collaborations - Vitae enters alliance to develop and commercialize hypertension treatment

Coronary Artery Calcification - Social network indices are associated with coronary artery calcification

Coronary Artery Disease - Case Method Learning-supported lipid-lowering strategy is cost-effective

Coronary Artery Disease - High resting heart rate is a predictor for total and cardiovascular mortality

Coronary Artery Disease - Optimized pharmacological therapy can improve prognosis of CAD patients

Cytomegalovirus - Integrin alphavbeta3 is a coreceptor for human cytomegalovirus

Dengue Epidemic - Anticipating emergence/preventing spread reduces effects of dengue epidemics

Dengue Fever - Ultrasound assists in diagnosis of dengue fever

Dextran Sulfate - Dextran sulfate may interfere with leukocyte-endothelial cell adhesion

Diabetes Control - Pager-sized monitor for diabetes control receives FDA clearance

Diagnostics - U.S. FDA grants 510(k) clearance for blood screening controls

Diagnostics - U.S. FDA grants clearance for immunoassay for diagnosing venous thrombembolism

Diet & Nutrition - High-energy intake provides folate intake necessary for tHcy decrease

Diet & Nutrition - Vitamin deficiencies may aggravate the risk of coronary artery disease.

Dilated Cardiomyopathy - Blood flow responses imply signaling defects or structural anomalies

Drug Development - CXR Biosciences collaboration to establish drug screening platform initiated

Drug Development - Microfluidic device detects agonist-induced platelet calcium flux

Echocardiography - Positive stress ECG is a valid method for testing high-risk patients for CAD

Electrocardiography - Dipyridamole-stress SAECG easily detects CAD and myocardial ischemia at bedside

Embryonic Stem Cell Research - BMP signaling inhibition by Noggin induces cardiomyocyte ESC differentiation

Embryonic Stem Cell Research - Embryonic stem cell lines derived on serum-free placental fibroblasts

End-Stage Renal Disease - Lanthanum carbonate suitable for use during hemodialysis

Epstein-Barr Virus - Phenotype and frequency of Epstein-Barr virus-infected cells determined

Erythropoiesis - Kell and XK transcripts occur early during erythropoiesis

Etiology - Genetic analysis of common diseases in postmenopausal women is funded

Finance - Medical device company prices IPO of common stock at $14 per share

Follicular Cancer - Follicular thyroid carcinoma distinguished from adenoma

Genetics & Genomics - FGF2 expression cannot be referred to as an independent clinical marker for CAD

HIV/AIDS Coinfection - HIV-specific cytolysis/increased IL-10 associated w/ S. mansoni coinfection

HIV/AIDS Dementia - HIV-induced alterations in CNS converge at neuronal p53 activation

HIV/AIDS Drug Development - Cycloamide-derived HIV protease inhibitors have antiretroviral activity

HIV/AIDS Drug Development - Ginsenosides block ritonavir-induced vascular dysfunction of coronary arteries

HIV/AIDS Drug Development - IL-4 antisense DNA inhibits pathogenic simian HIV replication in macaques

HIV/AIDS Drug Effect - Endoplasmic reticulum stress linked to protease inhibitor-related dyslipidemia

HIV/AIDS Drug Resistance - Mutations not associated with primary antiretroviral resistance in Chili

HIV/AIDS Drug Side Effect - Intracellular cytokines may model abacavir hypersensitivity immunoregulation

HIV/AIDS Epidemiology - Mathematical models make qualitative predictions about spread of HIV over time

HIV/AIDS Epidemiology - Mutagenetic trees describe accumulation of HAART-induced HIV mutations

HIV/AIDS Lipodystrophy - Lipodystrophy severity impacts negatively on body image of HIV-infected patients

HIV/AIDS Lipodystrophy - Risk factors identified for fat atrophy & fat deposition development in HIV/AIDS

HIV/AIDS Pain Management - Pain has substantial impact on physical performance and QOL among HIV patients

HIV/AIDS Pathogenesis - Findings describe new data in HIV/AIDS pathogenesis research

HIV/AIDS Pathogenesis - Fusion activity of HIV-1 gp41 depends on interhelical interactions

HIV/AIDS Pathogenesis - P53 is a proapoptotic signal transducer involved in AIDS

HIV/AIDS Prognostics - HIV-1-specific CD4 cell responses+IgG2 Ab predicts long-term nonprogression

HIV/AIDS Wasting - NRTI is main determinant of mtDNA depletion in adipose tissue of HIV patients

HIV/AIDS-Related Infection - Invasive S. pneumoniae infections declining in HAART era

Heart Disease - Association of H. pylori infection and ischemic HD remains debatable

Heart Disease - Pharma company begins manufacturing torcetrapib/atorvastatin calcium

Helicobacter Pylori - Probiotics improves tolerance to Helicobacter pylori eradication therapy

Hematology - Cell type and developmental stage guide the efficacy of RNA interference

Hematology - Reports add new data to hematology research

Hematopoiesis - PIG-A mutations occur in differentiated progenitors rather than HSCs

Hemodialysis - Silent cerebral infarction is risk factor for vascular events in renal patients

Hemoglobin - Alpha-hemoglobin structure studied, protective mechanism for heme revealed

Hemoglobin - O-raffinose crosslinked hemoglobin lacks site-specificity in cavity

Hepatitis B Virus - Occult hepatitis B is uncommon among dialysis patients in Italy

Homocysteine - Review focuses on the role of homocysteine in development of heart disease

Human Papillomavirus - HPV-directed cell-mediated immune response plays role in wart resolution

Hypoxia - Hypoxia studied, protective role of vitamin C defined

Imaging - Recent studies add new data to imaging research

Inhibitory Factors - Leukemia inhibitory factor blocked early differentiation of skeletal muscle

Intracranial Atherosclerosis - Study determines factors associated with occult coronary artery disease

Ischemia - Forebrain ischemia studied, receptor-tyrosine kinase interactions revealed

Ischemia - New findings in the area of ischemia described

Legal Issues - U.S. District Court jury finds patents infringed by Boston Scientific stents

Legionella Pneumophila - Sequence-based L. pneumophila typing concordant and discriminatory

Leukapheresis - Magnesium supplementation does not reduce side effects of leukapheresis

Leukemia - Conserved molecular signatures found in leukemia

Leukemia - Leukemogenesis linked to covalent modifications of chromatin

Lipoproteins - Coadministration of EZE with ATV led to greater reductions in LDL-C

Liposomes - Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells found

Listeria Monocytogenes - Cell-to-cell spread facilitates L. monocytogenes mom-to-fetal transmission

Liver Cancer - Reports advance knowledge in liver cancer research

Liver Transplants - Hepatic transit time indicated therapeutic response to radiofrequency ablation

Liver Transplants - Interventional radiology advised for liver transplantation

Liver Transplants - Liver transplant outcomes for hepatocellular carcinoma reviewed

Liver Transplants - Recommendations for surgical treatment of hepatoblastoma outlined

Lung Cancer - Researchers find lung cancer may begin in newly isolated lung stem cells

Malaria - Babies born from malaria-infected mothers susceptible to malaria early in life

Malaria - Further studies needed to determine accuracy of rapid malaria diagnostic tests

Medical Devices - Medical device company receives FDA approval for its high flux filter

Multiple Myeloma - Azaspirane hinders cancer proliferation factors in the bone marrow environment

Multiple Myeloma - Celgene's Revlimid: $321M in sales for multiple myeloma drug market in 2009

Mycobacterium Avium -  M. avium enters state of metabolic dormancy in response to starvation

Mycobacterium Tuberculosis -  M. avium subsp. paratuberculosis rapidly detected/typed from broth cultures

Mycobacterium Tuberculosis - HemZ is essential for heme biosynthesis in Mycobacterium tuberculosis

Mycobacterium Tuberculosis - Immunity to infection with Mycobacterium tuberculosis is influenced by age

Mycobacterium Tuberculosis - Transmembrane TNF provides acute control of M. tuberculosis infection

Mycobacterium Tuberculosis - W-Beijing MTB strains identified with targeted IS6110 fingerprints hybridization

Myelodysplastic Syndromes - U.S. FDA grants priority review for REVLIMID

Myeloma - Erk5 analyzed multifunctional role in multiple myeloma defined

Myeloma - International Staging System for multiple myeloma developed

Neural Stem Cell Research - Allopregnanolone promotes neural progenitor cell proliferation

Neural Stem Cell Research - BM-derived MSCs and CD90+ cells express neuroglial transcripts in culture

Neural Stem Cell Research - Neural stem cells may be beneficial to maintaining a normal striatal environment

Neural Stem Cell Research - Neural turnover in vomeronasal epithelium occurs through vertical migration

Neural Stem Cell Research - Neurogenesis diminishes with age

Neural Stem Cell Research - Xenopus Id3 required downstream of Myc for multipotent neural crest SC formation

Neutrophils - Neutrophil platelet-activating factor studied, stress-induced synthesis shown

Nocardiosis - Underlying diseases common in patients with nocardiosis

Nonpromyelocytic Acute Myeloid Leukemia - FLT3 mutation is adverse prognostic factor in nonpromyelocytic AML after SCT

Obstetrics - Pomegranate juice for moms may help babies resist brain injury

Obstetrics - Researchers publish new studies and findings in the area of obstetrics

Omega 3 Fatty Acids - Report describes potential for omega-3 fatty acids to prevent CV conditions

Oncology - Raf signals drive VEGF in Kaposi sarcoma-associated herpesvirus-infected cells

Pain Management - Company announces clinical trial for treatment of critical limb ischemia

Pathogenesis - Calcification inhibitors studied, role in kidney vascular calcification defined

Percutaneous Coronary Intervention - Full antiplatelet effect of 600 mg of clopidogrel is achieved after 2 hours

Personnel - Farallon Medical appoints Dr. Lee Carmack to vice president of development

Personnel - Hematologist Pierre Laneuville, MD, named to cryogenics company advisory board

Plasmodium Falciparum - Transfected erythrocytes studied, virulence factor trafficking clarified

Poliovirus - Cloning system mass produces virus-binding protein specific for poliovirus-1

Prostate Cancer - Statins should be tested as adjuvant therapy in prostate cancer trials

Pseudomonas Aeruginosa - Mab against P. aeruginosa protective against fatal pseudomonas sepsis

Pseudomonas Aeruginosa - Substance P regulates NK cell IFN-gamma production/resist to P. aeruginosa

RNA Research - MicroRNA expression in mouse stem cells study presented at conference

Respiratory Syncytial Virus - Group A RSV isolates from Argentina have more genetic variability than group B

Rotavirus Gastroenteritis - G9 is predominant genotype in pediatric rotavirus gastroenteritis in Belgium

SARS Coronavirus - Rolling circle amplification test rapid/sensitive for SARS coronavirus detection

Saccharomyces Cerevisiae -  Saccharomyces cerevisiae fungemia is an emerging infectious disease

Scleroderma - Skewed X chromosome inactivation mosaicism may play pathogenic role in women

Sepsis Therapy - YC-1 blocks proinflammatory cytokine production in mice

Staphylococcus Aureus -  S. aureus Panton-Valentine leucocidin+ isolates from diverse backgrounds

Statins - Atorvastatin treatment improved atherogenic lipoprotein profile in acromegaly

Stem Cell Blood Banking - Umbilical cord blood banks for transplantation differ in levels of quality

Stem Cell Research - Auditory nerve has capability for self-renewal and replacement

Stem Cell Research - CD34 microbeads used as magnetic cell label for in vivo cell visualization

Stem Cell Research - M-CSF drives differentiation of monocytes into anti-inflammatory M-DCs

Stem Cell Research - Mesenchymal stem cells inhibit differentiation/function of monocyte-derived DCs

Stem Cell Research - Mesenchymal stem cells remain of host origin long after APBSCT or BMT

Stem Cell Research - Microarray sheds slight on aberrant genes in agnogenic myeloid metaplasia

Stem Cell Research - Multipotent adipose-derived SCs are future tool for muscle cell-mediated therapy

Stem Cell Research - Ocular surface cells contain ABCG2-dependent SP cells with stem cell features

Stem Cell Research - PI-MECs are cellular targets for pregnancy-enhanced mammary tumorigenesis

Stem Cell Research - Scientists develop new technology to grow blood cells from embryonic stem cells

Stem Cell Research - Serum free T cell medium for expansion, activation of human T cells introduced

Stem Cell Research - Stem cell quiescence & SC pool maintenance not dependent on TGF-beta signaling

Stem Cell Research - Stromal-derived factor-1 promotes BM stromal SC growth/survival/development

Stem Cell Research - Systematic gene perturbation in planaria identifies genes for SC function

Stem Cell Research - Thrombopoietin initiates GP6 transcription during megakaryocyte differentiation

Stem Cell Research - Umbilical cord blood cells express neurotrophic factors

Stem Cell Research - WNT1 and WNT3a promote expansion of melanocytes through distinct modes of action

Stem Cell Therapy - Phase I clinical trials promising for stem-cell-based cardiac therapy

Stem Cell Transplantation - Mismatched-related cells are a viable therapy for patients with acute leukemia

Stem Cell Transplantation - T-cell chimerism molecular monitoring early after SCT predicts GVHD grades II-IV

Stem Cell Transplantation - Vestibulocochlear nerve supports fetal dorsal root ganlion xenotranplant

Stem Cells & Aging - Aging affects hematopoietic stem cells guidance toward the B-cell pathway

Stents - Data advance knowledge in stents research

Stents - Vivant Z stent was safe and efficacious in de novo coronary artery lesions

Systemic Lupus Erythematosus - SLE patients have a high prevalence of early carotid atherosclerosis

Thrombosis - Resection of jugular vein necessitated by radical neck dissection

Tissue Engineering - Condyle with chondral & osseous components derived from single SC population

Tissue Engineering - Porosity choice of 3D biomaterial scaffolds affects progression of osteogenesis

Toxicology - Shiga toxin studied, up-regulation of tissue factor activity described

Transfusion Medicine - New transfusion technology reduces pathogen transmission

Transfusion Medicine - U.S. FDA grants priority review for Exjade for chronic iron overload

Transplant Medicine - In utero bone marrow transplantation in swine mitigates kidney graft rejection

Tuberculosis - Children require higher INH dose to achieve concentrations comparable to adults

Tuberculosis - Gestational multidrug-resistant tuberculosis therapy not toxic among children

Tuberculosis - High-resolution CT detects activity of suspected smear negative pulmonary TB

Tumor Distribution - Different pneumoperitoneal pressures influenced tumor cell distribution in rats

Umbilical Cord Blood Banking - Semiautomated RBC depletion system saves time/improves cell recovery

Varicella Zoster Virus - VZV reactivates following discontinuation of aciclovir prophylaxis for HSCT

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