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Hematology Week

Susan Hasty, Publisher

Table of Contents . . . August 22nd, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Hematology Week | Other Publications

Lung Cancer - Lung cancer incidence increasing in Sardinia

SARS - Quarantine is cost saving and effective in containing emerging infections

Tuberculosis - High prevalence of tuberculosis among health care workers in Kampala

Tuberculosis - Low sunlight/vegetarian diet cause of vitamin D deficiency in foreigners with TB

Tuberculosis - Targeted screening strategies for pulmonary tuberculosis in prisons unreliable

Adverse Drug Reaction - Advance liver disease hampers tolerance to hepatitis C combination therapy

Alcohol Use - Chronic ethanol consumption may contribute to development of restenosis

Alzheimer Disease - ELISA developed for amino-terminally truncated beta-amyloid peptide quantitation

Anemia - Outcome of clinical analysis of chronic benzene poisoning revealed

Angiology - Children presenting with SoJIA may have coronary artery dilation

Angiology - Coronary retrograde perfusion may be technique for myocardial ischemia

Angiology - Researchers publish new studies and findings in the area of angiology

Angiology - Heat shock proteins analyzed, regulatory role in vascular muscle tone revealed

Angiology - Laser perforation mobilizes matrix graft adaptation in treated arteries

Angiology - Needle-guided ultrasound enhances cannulation success

Angiology - Researchers detail new studies and findings in the area of angiology

Angiology - Skin sterol associated with history of coronary events, published study states

Ischemia - Reports add new data to ischemia research

Antibiotic Resistant Bacteria - Metallo-beta-lactamase-resistant bacteria is an emerging epidemic

Anticancer Drug - Deguelin enhances leukemia cell chemosensitivity with active PI3K/AKT pathway

Antiplatelet Drugs - Alterations of receptor gene may be a mechanism for clopidogrel failure

Antituberculosis Therapy - Some antituberculous drugs alone or in combination enhance PMN functions

Apoptosis - Hsp70 overexpression examined, effect in neonatal brain injury defined

Arteriosclerosis - Long-term treatment with nicorandil may prevent cardiovascular events

Atherosclerosis - Angiogenic growth factors localize in carotid atherosclerotic plaques

Atherosclerosis - Deposition of cholesteryl linoleate results in inflammatory lesions

Atherosclerosis - Higher serum IL-18 levels may be associated with greater carotid IMT

Bartonella -  Bartonella causes a broad number of infectious diseases

Benzene Exposure - Occupational exposure to benzene in South Korea

Blood Banking - Controlled-rate freezing used to cryopreserve embryonic stem cells

Blood Clots - Scientists measured elastic moduli of individual fibrin fibers in fibrin clots

Blood Safety - Filtration company awarded long-term contract for leukoreduction filter system

Blood Vessels - Model quantifies spiral motion in vessels, reveals progress of stenosis

Bone Marrow - Predictors of posttraumatic growth after bone marrow transplantation examined

Business & Finance - Cord blood banking company reports strong growth

Business Update - European Union's CHMP adopts positive opinion for NOXAFIL

Business Update - HemoSense strengthens worldwide INRatio System distributor network

C-Reactive Protein - Study examined processing of CRP by human aortic endothelial cells

Cancer Risk Factors - Higher cancer risk found in progeny of mice exposed to X-rays before conception

Cancer Therapy - Deltec and Groshong central venous access port systems compared

Cancer Therapy - Hydrocortisone may play a key role in cancer immunotherapy

Cancer Treatments - PSA quick testing used to screen for prostate cancer

Cardiac Drug Therapy - Insufficient data exist to allow selection of specific inotropic agents

Cardiac Drug Therapy - Study examined cerivastatin/nifedipine in injured coronary arteries

Cardiac Surgery - Hextend and Hespan exhibit same effect on platelet function

Cardiac Therapy - COPD and reversibility should be ascertained before withholding beta-blockers

Cardiogenic Shock - RV dilatation identifies subgroup with an improved long-term prognosis

Cardiology - CRP discriminates poorly between people with/without coronary disease

Cardiology - Cardiac index measures compared during rapid fluid loading

Cardiology - Cardiology must embrace preventive interventions that forestall future events

Cardiology - Device enables the crossing of severe coronary artery stenosis

Cardiology - ECG is the most important diagnostic test for aortic regurgitation

Cardiology - MI patients with high BMI were less likely to have invasive coronary procedures

Cardiology - Model provides method to assess changes in cardiac electrophysiology

Cardiology - Study compares sirolimus-eluting stents with vascular brachytherapy

Cardiology - Study examined recruitable coronary collateral blood ECG changes during PCI

Cardioprotection - Study examined effects of flavonoid treatment on endothelial functions

Cardiopulmonary Bypass - ACT system increased the heparin dose required to exceed target ACT

Cardiovascular Assessment - NIRS provides a valuable method to assess working muscle vasodilation

Cardiovascular Disease - Are there reliable mechanisms relating psychosocial stress to CV diseases?

Cardiovascular Disease - Experimental studies suggest NAD(P)H oxidase activates vascular remodeling

Cardiovascular Disease - Method measures all known plasma forms of vitamins B6 and B2

Cardiovascular Research - 2-methoxyestradiol exerts renal and CV protective effects

Cardiovascular Research - Aerobic exercise increase cardiac function in offspring of HT parents

Cardiovascular Research - Deficiency of eNOS is compensated in coronary circulation, not in aorta

Cardiovascular Research - Study examined autonomic activation in response to stress and anger imagery

Cardiovascular Risk Factors - Specificity of low ankle-brachial index to predict CV outcomes is high

Cardiovascular Risk Factors - Strong associations were found between social class and CV risk factors

Childhood Cancer - Management strategies for asymptomatic cardiac damage discussed

Childhood Cancer - Prevalence of RIB anomalies in normal and childhood cancer patients calculated

Chronic Lymphocytic Leukemia - Trial begins for telomerase inhibitor drug GRN163L in patients with CLL

Cisplatin - Cisplatin, gemcitabine and treosulfan used to treat metastatic uveal melanoma

Clinical Trials - Eight-week doxycycline course safe/effective for lymphatic filariasis

Clinical Trials - Florida hospital approved to enroll patients in phase 2 synthethic blood trial

Clinical Trials - Prasugrel and clopidogrel both resulted in low bleeding rates in PCI patients

Coagulation Therapy - Brand-name and generic warfarin have equivalent performance

Coronary Artery Bypass - Depression and anxiety don't alter CABG candidates' neuropsychology

Coronary Artery Bypass - Depression linked to poor postoperative recovery

Critical Care Medicine - Test to rule out heart attack could reduce hospital admissions

Crohn Disease - MAP specific IS900 DNA is a predominant feature of Crohn disease

Cryptococcus Neoformans - CD8+ T cell function independent of CD4+ T cells in C. neoformans infection

Cytomegalovirus - CMV-specific cytotoxic T cells expanded using recombinant polyepitope

Diagnostics - Contrast-enhancement discerns vessel activity in multiple myeloma images

Diagnostics - Young patients with acute leukemia share unique genetic features

Diet & Nutrition - Effects of diet on blood lipids and energy expenditure examined

Diet & Nutrition - Functional foods may offer stress management benefits

Diet & Nutrition - Olive oil compounds are antioxidants, anti-inflammatories, and antimicrobials

Disease Associations - SARS studied, response of memory CD8+ T cells revealed

Dyslipidemia - Effects of acute coffee ingestion on lipid levels determined

Echocardiography - 3D ECG enables measurement of aortic root in Marfan syndrome

Echocardiography - Ultrasound alters microbubble-based myocardial perfusion assessment

Embryonic Stem Cell Research - Patient-specific ESCs derived from somatic cell nuclear transfer blastocysts

End-Stage Renal Disease - Cortical excitability characterized in different patient populations

Endothelial Cells - Computer-controlled microcirculatory EC culture system devised

Epstein-Barr Virus - SM protein enhances expression of Epstein-Barr virus lytic genes

Escherichia Coli -  E. coli 0157:H7 outbreak caused by nonintact blade-tenderized frozen steaks

Escherichia Coli -  E. coli alpha-hemolysin studied, structural/functional role of LPS shown

Estrogen - Estrogen elicits cortical zone-specific effects on fetal adrenal gland growth

Familial Hypercholesterolemia - DNA array provides information about mutations and familial hypercholesterolemia

Fibrin Glue - Intralesional injection of Tisseel fibrin glue used for lymphangioma resection

Finance - Genomics-focused pharma reports Q2 loss of $15.7 million

Finance - Laboratory holdings company reports second quarter 2005 financial results

Food Poisoning - Yusho poisoning affected hematogenesis

Gastric Cancer - Serum aberrant methylation compared to conventional tumor markers

Gene Therapy - Enhanced CD20 expression in tumor B cells controlled by ERK-dependent mechanisms

Genital Herpesvirus Infection - Topical microbicides needed for prevention of genital herpes infections

HAM/TSP Pathogenesis - Interferon-beta 1a affects immune mechanisms central to HAM/TSP pathogenesis

HIV/AIDS Coinfection -  Neisseria gonorrhoeae enhances infection of dendritic cells by HIV-1

HIV/AIDS Disease Progression Risk Factors - Pattern/type of non-injection drug use associated with progression to AIDS

HIV/AIDS Drug Development - Amino acid Asn136 of HIV-1 RT enables rational design of RT inhibitors

HIV/AIDS Drug Development - Mesuol inhibits HIV-1 replication by targeting NF-kappa B pathway

HIV/AIDS Drug Development - Short hairpin RNAs targeting human cyclin T1 suppresses HIV-1 replication

HIV/AIDS Education - Low health literacy associated with HIV test acceptance

HIV/AIDS Education - Peer education or lecture increases HIV/AIDS knowledge among college students

HIV/AIDS Epidemiology - Differential susceptibility important determinant of steady-state HIV prevalence

HIV/AIDS Epidemiology - Majority of HIV-1 cases among Africa-born patients in Minnesota are non-B

HIV/AIDS Needlestick Injury - Postexposure practice inadequate in medical students with needlestick injury

HIV/AIDS Opportunistic Infection - Calciviruses may be important opportunistic pathogen in HIV-infected children

HIV/AIDS Pathogenesis - CD4+ cells have impaired base excision repair/oxidative base lesion accumulation

HIV/AIDS Pathogenesis - Cultured myeloid dendritic cells from HIV patients fail to differentiate

HIV/AIDS Pathogenesis - HIV Tat induction of IL-10 dysregulation associated with PKR activation

HIV/AIDS Pathogenesis - Infectivity of CXCR4-using isolates depends on CD4 expression

HIV/AIDS Pathogenesis - Peripheral S-phase T cells in HIV disease have a central memory phenotype

HIV/AIDS Pathogenesis - Reports describe recent advances in HIV/AIDS pathogenesis research

HIV/AIDS Perinatal Transmission - Nevirapine resistance after single NVP dose higher in women with HIV-1 subtype C

HIV/AIDS Pharmacokinetics - Body weight/female gender affects enfuvirtide clearance but not safety/efficacy

HIV/AIDS Prevention - HIV prevention program increases willingness to reduce adolescent risk behaviors

HIV/AIDS Prognostic Marker - Early HIV-1 PBMC DNA level predicts disease progression independent of RNA/CD4+

HIV/AIDS Research - Single-chain antibody against HIV-1 external glycoprotein gp120 developed

HIV/AIDS Research - Soluble HIV trimeric Env fragment adopting prefusion gp41 structure developed

HIV/AIDS Risk Behavior - Adults with severe mental illness engage in risky sexual behaviors

HIV/AIDS Risk Behavior - Sexual risk behavior is high among youths in psychiatric care

HIV/AIDS Susceptibility - Screening test may be developed to determine susceptibility to HIV/AIDS

HIV/AIDS Transmission - Incorporation of ABO antigens by HIV-1 may affect viral transmission

HIV/AIDS Treatment Failure - Prevalence of virologic response disappears after 96 weeks on HAART

HIV/AIDS Vaccines - Researchers provide details of new studies and findings in the area of HIV/AIDS vaccines

HIV/AIDS-Related Drug Use - Methadone treatment decreases heroin overdose-related mortality in HIV patients

HIV/AIDS-Related Kaposi Sarcoma - HAART plus liposomal doxorubicin induces tumor remission in HIV-related KS

Health Needs Assessment - Health needs assessment is reliable means of identifying patients' needs

Heart Disease - Response to oral bacteria may be more relevant to HD than periodontic signs

Hematology - Genetically modified natural killer cells overcome HLA-mediated resistance

Hematology - Hematologic follow-up recommended for patients treated with radioiodine

Hematology - Researchers describe findings in hematology studies

Hematopoietic - ESCs grown without embryonic fibroblasts/conditioned media undergo hematopoiesis

Hemolytic Uremia -  Streptococcus pneumoniae plus hemolytic uremia is rare in Canada

Hepatic Resection - Novel ultrasound-directed technique used in major hepatic resections

Hepatocellular Carcinoma - Risk factors associated with bile leakage after hepatic resection

Hip Replacement - Aprotinin and EACA treatment reduces post-THA blood loss

Hyperaldosteronism - BK channel dysfunction may underlie forms of hyperaldosteronism

Hyperlipidemia - Clinicians must be aggressive about hyperlipidemia in transplant patients

Hypertension - ACE I/D polymorphism is not useful to predict anti-HT treatment response

Hypertension - Children operated for aortal coarctation have more arterial rigidity

Imaging - Estimation of pulmonary artery pressure by MRI was not feasible

Immunogenetics - Immunoglobulin KV genes isolated by PCR from macaque genomic DNA

Information Technology - Institute for Transfusion Medicine turns to Quovadx for data integration

Intimal Hyperplasia - Patient enrolment in study of therapy to prevent blood vessel blockage complete

Ischemia - Glomerular epithelial cell injury studied, role of ER protein shown

Ischemia - Recent findings illuminate research in ischemia

Kidney Disease - Company reports positive results from DCOR trial favoring use of Renagel

Knee Replacement - Epinephrine-augmented hypotensive epidural anesthesia lowers blood loss

Leptospirosis - Blood monocyte glycolipoprotein studied, Leptospira activation demonstrated

Leukemia - Amino acid concentrations in cerebrospinal fluid measured in ALL children

Leukemia - Children do not show increased susceptibility for developing secondary AML

Leukemia - Fecal fungal flora of immunosuppressed patients studied

Leukemia - Glycated fibrinogen-methotrexate conjugates showed antileukemic activity

Leukemia - Intrathecal chemotherapy evaluated in children with acute leukemia

Leukemia - MLL fusion proteins suppressed p53-mediated response to DNA damage

Liver Transplant - Causes of early acute graft failure elucidated

Lung Transplant - Oxygenation ratio shows promise as early graft dysfunction marker

Lymphoma - MTAP gene silenced by promoter hypermethylation in lymphoma cells

Malaria -  P. falciparum malaria occurred in visitors to E. Coast of Dominican Republic

Malaria -  Plasmodium falciparum STEVOR peptides studied, RBC binding defined

Malaria - Research in malaria provides new insights

Malaria Vaccine -  A. nancymaae is an animal model for malaria subunit vaccine development

Multidrug Resistant - Carbapenem use {{>=}}7 days risks multidrug resistant to P. aeruginosa

Multiple Myeloma - COX-2 is an independent predictor of poor outcome in multiple myeloma

Multiple Myeloma - Cancer-testis antigens correlate with plasma-cell proliferation

Multiple Sclerosis - Modulation of blood vessels is affected by baroreflex dysfunction in MS

Muscular Dystrophy - Muscle side population cells reveal myogenic potential

Mycobacterium Avium - High-temperature/short-time pasteurization inactivates M. avium in milk

Mycobacterium Kansasii - High phenotypic variability of M. kansassi may complicate identification

Mycobacterium Tuberculosis - Early treatment improves MTB-induced disseminated intravascular coagulation

Mycobacterium Tuberculosis - Inducible promoter generates conditional Mycobacerium tuberculosis auxotroph

Mycobacterium Tuberculosis - Pyrosequencing assay rapidly detects rifampin-resistant M. tuberculosis

Mycobacterium Tuberculosis - Virulence of MTB isolates dependent on phenolic glycolipid produced by bacilli

Myeloma - Case of reactive plasmacytosis mimicking multiple myeloma found in pSS patient

Myocardial Infarction - NT-proBNP and renin are predictors of MI risk after stroke or ischemic attack

Neuroscience - New findings in the area of neuroscience described

Neurotransmitters - Blood-retinal barrier studied, nature of Leu transport defined

Norovirus - Multiplex real time RT-PCR assay quantitates norovirus genogroups I and II

Nosocomial Infections - Molecular epidemiology traces hepatitis C outbreaks in a hemodialysis unit

Oncology - Recent findings illuminate research in oncology

Otorhinolaryngology - Use of anterolateral thigh flaps to reconstruct head and neck defects evaluated

Pamidronate - Pamidronate and 1,24(S)-dihydroxyvitamin D-2 inhibited growth of cancer cells

Pancreatic Ductal Carcinoma - Factors predicting recurrence after pancreatic ductal carcinoma resection listed

Patents - Company receives notice of allowance for key U.S. EVLT patent

Pediatric Cardiac Surgery - Surgery for aortic coarctation has excellent results in children under 1 yr. old

Percutaneous Coronary Intervention - PCI with drug-eluting stents highly cost-effective in Germany

Pneumonia -  C. pneumoniae kills cells by a caspase-independent pathway

Prognostics - CT scans predicted weight of Wilms tumor

Prostate Cancer - AMACR expression altered in prostatic adenocarcinoma following hormone therapy

Pulmonary Arterial Hypertension - Increased ADMA plasma levels are associated with poor outcome in IPAH

Pulmonary Hypertension - Assessment of cardiopulmonary function reviewed

Radiation Therapy - Risk of CV mortality after irradiation for childhood cancer is increased

Renal Cell Cancer - Renal cell carcinoma reported secondary to tuberculous nephritis

Respiratory Distress Syndrome - Nitric oxide added to CPAP treatment improves oxygenation

SARS - Anti-SARS-coronavirus drugs are crucial for control of future outbreaks

SARS - Protective mask usefulness during SARS outbreak varies among healthcare workers

Smallpox Vaccine - Stable/effective smallpox vaccine constructed from highly attenuated vaccinia

Statins - Rosuvastatin may be an option for patients requiring 50% LDL reduction

Stem Cell Research - BMSCs have limited plasticity to transdifferentiate into cardiac cells in vitro

Stem Cell Research - Dopamine specifically inhibits forebrain neural stem cell proliferation

Stem Cell Research - Postnatal muscle-derived stem cells have extra capacity for self-renewal

Stem Cell Research - Provider of stem cell transplantation, therapy passes 200 cord blood transplants

Stem Cell Research - TGF-beta 1 tightly regulates intestinal mast cell growth/phenotype/function

Stem Cell Research - TGF-beta-1-2-3 & IFN-beta induce hepatocyte growth factor secretion by microglia

Stem Cell Transplantation - CD133+ SCs used for haploidentically mismatched peripheral blood SCT

Stem Cell Transplantation - Fibrinolytic test findings may facilitate early VOD diagnosis in pediatric HSCT

Stem Cell Transplantation - HLH patients with NK-cell deficiency type 3 will probably require SCT to survive

Stem Cell Transplantation - High-dose cyclophosphamide effective for refractory MM after SCT relapse

Stem Cell Transplantation - Mesenchymal stem cell transplants can improve heart function

Stem Cell Transplantation - Most HLH patients using matched related or unrelated donor survive SCT

Stem Cell Transplantation - New research in the area of stem cell transplantation detailed

Stem Cell Transplantation - Nonmyeloablative SCT corrects disease phenotype in leukocyte adhesion deficiency

Stem Cell Transplantation - Reduced-intensity SCT successful in malignant lymphoma/ileostomy patient

Stroke - Atherosclerosis and cervical artery dissection are not well examined

Stroke - Study analyzed outcomes of stroke patients requiring ventilation

Stroke - Study examined predictors of reocclusion in stroke patients treated with tPA

Stroke - Transthoracic ECG should be performed for all stroke patients in sinus rhythm

Systemic Lupus Erythematosus - First patient treated in pivotal phase III lupus nephritis study

Thalassemia - Single-tube osmotic fragility test suitable for diagnosis

Tissue Engineering - Autologous blood vessels engineered from human cells

Tissue Engineering - BMP-2 induces chondrocyte-specific gene expression in synovium-derived SCs

Tissue Engineering - Cultured porcine cartilage pellets used to study rheumatoid arthritis

Tissue Engineering - Tissue engineering for airway reconstruction avoids tracheotomy

Tissue Engineering - Tissue-engineered vascular autografts seeded with autologous bone marrow cells

Toxoplasma Gondii - Stage-specificity of SRS Ags determines immunogenicity in T. gondi infection

Tuberculosis - Beijing genotype is a major cause of drug-resistant tuberculosis in Kazakhstan

Tuberculosis - Differential regulation of local immune response crucial for containment of MTB

Tuberculosis - ELISA more sensitive than immunoblotting for detection of tuberculosis antibody

Tuberculosis - Short-course chemotherapy safe/effective in pediatric respiratory tuberculosis

Tuberculosis - Tuberculosis drugs not handled properly in lower southern Thailand

Tuberculosis - Tuberculosis risk patterns determined for recent immigrants to Ontario

Tuberculous Meningitis - Isoniazid + rifampicin resistance strongly predictive of death in TB meningitis

Type 1 Diabetes - Pancreatic islet transplantation stabilizes diabetes-related pathologies

Urology - Preoperative chlormadinone reduces blood loss during prostate surgery

Vascular Disease - Heritable deficiency of antioxidant enzymes favors ROS accumulation

Vasculitis - Persisting endothelial dysfunction in vasculitis may have consequences

Venous Leg Ulcer - Low-level laser therapy doesn't enhance wound healing

West Nile Fever - WNF encephalitis may present with functional/intellectual impairment in elderly

Yersinia - MAPK/NF-kappa B inhibition needed for rapid apoptosis in infected cells

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