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Hematology Week

Susan Hasty, Publisher

Table of Contents . . . September 19th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Hematology Week | Other Publications

Platelets - Platelet activation analyzed, role of lipid rafts defined

Stem Cell Transplantation - Donor cell allodepletion may reduce severe acute GVHD rate in older patients

Thrombosis - Factor VIII antibody binding studied, role of phospholipid vesicles defined

Tissue Engineering - Wound re-epithialization observed following skin substitute transplantation

Acute Coronary Syndrome - Clinical trial evaluating rNAPc2 as heparin replacement enrollment initiated

Acute Lymphoblastic Leukemia - ALL subtypes originate, transform at distinct hematopoietic development stages

Acute Myocardial Infarction - Coronary clearance frame count useful as microvascular perfusion index

Anemia - Impact of weekly dosing of epoetin alfa on anemic cancer patients examined

Anemia - Pretreatment anemia associated with poorer survival in gastric cancer patients

Anemia - Researchers discover new pathway for the synthesis of heme in zebrafish

Atherosclerosis - Researchers' findings advance atherosclerosis research

Aneurysms - Bioactive Matrix coils can improve postembolization healing

Angiology - CD151 promotes neovascularization in rodent ischemic hindlimbs

Angiology - Platelets play an indirect role in the regulation of new vessel formation

Angiology - Researchers provide details of new studies and findings in the area of angiology

Angiology - Risk of catheter-related bloodstream infection assessed

Angiology - Thrombin-stimulated platelets examined, tyrosine phosphorylation revealed

Cardiology - New findings in the area of cardiology detailed

Anticonvulsant Therapy - Effects of acute valproic acid overdose characterized

Antiphospholipid Syndrome - Antiphospholipid syndrome studied, FXII antigenic binding sites clarified

Aortic Stenosis - Cardiac catheterization may underestimate actual ejection time

Apoptosis - Apoptosis-based therapies for hematologic malignancies discussed

Artificial Organs - Numerical-hydraulic circulatory model developed

Asthma - Peripheral blood cell 15-HETE output marks aspirin-sensitive patients

Cardiology - Researchers' data advance cardiology research

Atherosclerosis - CRP correlates directly with atherosclerosis in rheumatoid arthritis patients

Atherosclerosis - New research in the area of atherosclerosis detailed

Biomedical Engineering - Combined growth factors enhance marrow cell driven bone regeneration

Bioterrorism - Dutch biotech, U.S. Navy to test AdVac-based vaccine against anthrax, plague

Blood Banking - CD34+ cell recovery from cryopreserved autologous stem cell products variable

Cardiology - Researchers' work adds to cardiology body of knowledge

Blood Safety - Exposure levels of di(2-ethylhexyl) phthalate from blood bags reported

Bone Marrow - Endotoxemia analyzed, cytokine response and granulopoiesis clarified

Bone Marrow - Host gammadelta T cells appear to exacerbate GVHD

Business Update - East Coast customer base continues growth for Wyndgate

Cancer Risk Factors - Risk of cancer increased among siblings of long-term childhood cancer survivors

Cancer Therapy - Highly efficient intrabody mediates VEGF signal inhibition

Cardiology - Studies advance knowledge in cardiology research

Cardiology - New findings in the area of cardiology described

Cardiology - U.S. FDA clears catheter for long total occlusions in superficial femoral artery

Diet & Nutrition - Recent findings in diet & nutrition provide new insights

Cardiology - Utility of superior vena cava echocardiography clarified

Cardiolpulmonary Bypass - Transfusion of blood from bypass circuit increased postop hematocrit

Cardiomyopathy - Infrared endoscope enables direct coronary sinus visualization

Cardiopulmonary Bypass - Nitric oxide treatment may reduce postperfusion lung injury

Cardiovascular Disease - CV risk is lower in rheumatoid arthritis patients treated with TNF blockers

Cardiovascular Disease - Iron chelation can prevent oxidative stress-induced myocardial damage

Hematology - Recent findings in hematology described

Cardiovascular Disease - New approach to obtain arteriolar-to-venular diameter ratio is being tested

Cardiovascular Disease - Review examines whether hyperuricemia is a risk factor for adverse CV outcomes

Cardiovascular Magnetic Resonance - Low sensitivity limits single estimation for detecting iron overload

Cardiovascular Research - Study explored the impact of dyslipidemia on EDHF

Tissue Engineering - Researchers' work adds to tissue engineering body of knowledge

Cardiovascular Risk Assessment - Study assessed prognostic significance of measurements of SBP and PP

Cerebrovascular Disease - Researchers compared CASL to PET to assess cerebral blood flow

Chemotherapy - Mylotarg administered after start of chemotherapy produced high remission rate

Chronic Myelogenous Leukemia - Protein kinase inhibitors put under high throughput screening

Cisplatin - Efficacy and safety of intravenous topotecan combinatory chemotherapy tested

Clinical Trials - Amendment to IND for pilot study of blood substitute in brain injury submitted

Clinical Trials - Multinational randomized clinical trial of estradiol eluting stent begun

Colon Cancer - High oxygen radical production found in patients with sporadic colorectal cancer

Congenital Heart Disease - Activation of platelets by high shear rate is possible within grafts

Coronary Artery Bypass - Kidney transplant patients have bypass survival advantage

Coronary Artery Bypass - Multidetector CT and EBT suitable for graft patency assessment

Coronary Artery Bypass - Off-pump CABG improves renal function

Coronary Artery Bypass - Prostacyclin therapy attenuates protamine complications

Coronary Artery Bypass Graft - Acute normovolemic hemodilution provided cardiac protection

Coronary Artery Disease - U.S. FDA approves ACEON to reduce risk of cardiovascular mortality

Coronary Care - Large proportion of coronary event fatalities continue to occur outside hospital

Coronary Heart Disease - Scientists tested association of new biomarkers with traditional CV risk factors

Coronary Stent - Novel computational models used to clarify hemodynamics

Cyclooxygenase Inhibitors - COX-3 mRNA has been isolated in many tissues

Diagnostics - Acute dengue fever diagnosed by both RT-PCR and IgM detection

Diagnostics - Plasma chemokines predict the efficacy of hepatitis C antiviral therapy

Diagnostics - Researchers' work adds to diagnostics body of knowledge

Diagnostics - Technique provides useful information for assessing coronary artery disease

Diet & Nutrition - Cranberries may aid clearance of excessive cholesterol in circulation

Diet & Nutrition - Recent findings in diet & nutrition described

Digestive Bleeding - Capsule endoscopy superior to standard diagnostic tests

Dlk1 Overexpression - Dlk1 may be overexpressed in myelodysplastic syndrome and acute myeloid leukemia

Drug Development - Nebulization of SLP-based antitubercular drugs improves bioavailability

Drug Development - Study of isatoribine in hepatitis C demonstrates proof of concept

Echocardiography - Recent studies add new data to echocardiography research

Embryonic Cell Transplantation - Serum deprivation decreases rate of embryonic cell death after transplantation

Endovascular Intervention - U.S. FDA approves Zenith Renu AAA Ancillary Graft

Epstein-Barr Virus - Researchers' findings advance epstein-barr virus research

Feline Immunodeficiency Virus - IgG from acutely infected cats blocks mucosal FIV infection

Fibrinogen - Review discusses noninherited and inherited variations of fibrinogen

Finance - Carbohydrate drug-development company comments on Q2 loss

Finance - Drug delivery company completes private financing

Genetics & Genomics - 677CT/1298AC detection in MTHFR genotyping results to be interpreted cautiously

Genetics & Genomics - Preabsorption with protein-L: A tool for removing interfering immunoglobulins

HIV/AIDS Epidemiology - HSV-2 is a primary cofactor in facilitating the spread of HIV infection

HIV/AIDS HAART - Lopinavir CSF concentrations exceed the 50% inhibitory concentration for HIV

HIV/AIDS Pharmacogenetics - Mutations related to altered drug pharmacokinetics influences HAART efficacy

HIV/AIDS Vaccines - Researchers' work adds to HIV/AIDS vaccines body of knowledge

HIV/AIDS Viremia - HIV RNA blips during HAART may reflect ongoing viremia which impair CD4 recovery

Hematology - New findings in hematology described

Hematopoiesis - Angiopoietins accelerate marrow vessel regeneration after myelosuppression

Hemodialysis - Hemodynamics in punctured vascular access grafts characterized

Hemodialysis - Implementation of DOQI vascular access guidelines lowers morbidity

Hepatitis B Virus - The hepatitis B virus antigenic loop fosters hepatitis delta virus infectivity

Hepatitis C Therapy - Low accelerating doses of antiviral therapy treat advanced hepatitis C

Hepatitis C Virus - Serum copper and zinc levels are unchanged in patients with chronic hepatitis C

Hepatocellular Cancer - Nonsurgical therapies of hepatocellular carcinoma evaluated

Hypertension - Reports add new data to hypertension research

Hypotension - Hemopressin and bradykinin studied, hypotensive effects compared

Hypoxia - Neonatal hypoxia-ischemia examined, effect on BH4 and NOS levels reported

Imaging - Findings advance knowledge in imaging research

Immunology - Autologous HSCT can alter disease progression in severe autoimmune disease

Immunopharmacology - UTE appears to indirectly modulate immune activity

Infections -  Plasmodium falciparum examined, heme containing peroxidase characterized

Kaposi Sarcoma-Associated Herpesvirus - Researchers provide details of new studies and findings in the area of kaposi sarcoma-associated herpesvirus

Kidney Cancer - Multidetector computed tomography compared to magnetic resonance imaging

Leukemia - Ethnic difference in daycare attendance and early infections related to ALL risk

Leukemia - Health watch exposure estimates underestimated benzene exposure

Leukemia - Protocol for the treatment of newly diagnosed APL children delineated

Leukemia - Wnt16 inhibition induced apoptosis in ALL cells

Liver Cancer - Fatigue patterns studied in liver cancer patients receiving chemoembolization

Liver Cirrhosis - HIV coinfection cuts survival in those with HCV-related decompensated cirrhosis

Lymphoma - Relation between benzene exposure and non-Hodgkin lymphoma studied

Lymphoma - STAT5 is a modifier of interleukin-7-induced lymphomas

Marketing - Japanese, U.S. companies sign agreement to co-market diabetes diagnostics tools

Mental Health - Patients with hematological malignancies showed a restricted body image

Monocytes - Monocyte chemotaxis analyzed, nature of receptor activation defined

Mycobacteria Abscessu Outbreaks -  Mycobacteria abscessu outbreak in U.S. linked to offshore surgicenter

Myelodysplastic Syndrome - Aberrant SOCS-1 methylation induces transcriptional silencing in myeloid cells

Myeloma - Zoledronic acid down-regulated adhesion molecules of bone marrow stromal cells

Myocardial Infarction - Chronic CO inhalation worsens heart failure in rats with myocardial infarction

Myocardial Infarction - Self mesenchymal stem cells and endothelial progenitors aid infarcted hearts

Neurogenesis - Shc3 affects high-grade astrocytoma survival

Neurology - Baicalin analyzed, protective effects in rat hippocampus revealed

Neutrophils - Neutrophil leukotriene production assessed, role of phospholipase revealed

Norwalk Virus - Secretor status most predictive of risk of Norwalk virus infection

Obstetrics - Findings describe new data in obstetrics research

Oncology - Recombinant human erythropoietin suppresses intratumoral blood vessels

Oral Contraceptives - Oral contraceptives examined, decreased activated protein C sensitivity defined

Oral Health - Biomarkers detect angiogenesis in oral hemangiomas and pyogenic granulomas

Ovarian Cancer - Topotecan in pretreated patients with recurrent ovarian carcinoma evaluated

Percutaneous Coronary Intervention - Low plasma PAI-1 levels linked to late restenosis risk

Peripheral Vascular Disease - Early growth response factor-1 gene transfer bolsters limb revascularization

Personnel - Six new members join blood cancer research funding group's board of directors

Physiology - Plasminogen activator inhibitor studied, regulation in lung fibroblasts defined

Platelets -  C. pneumoniae interaction with platelets leads to ROS production

Platelets - Eptifibatide inhibits hypothermia-induced platelet aggregation in vitro

Platelets - Findings in platelets provide new insights

Platelets - Mucetin-activated platelets analyzed, translocation to cytoskeleton clarified

Platelets - New agents that target signaling pathways in platelets promise greater efficacy

Platelets - Platelet activation analyzed, roles of Tyr phosphorylation defined

Portal Venous Obstruction - Endoscopic band ligation improves sclerotherapy results in children

Product Licensing - Pharma company acquires rights for novel oral phosphate binder

Radiation Research - Transcriptional response of HUVEC to ionizing radiation reported

Rheumatic Disease - Clinical utility of diagnostic tests reviewed

SARS - New research in the area of SARS detailed

Sepsis - Diagnostics company and Biosite collaborate to develop diagnostics for sepsis

Solid Tumors - Epoetin alfa 40000 U once weekly and intravenous iron supply treated solid tumor

Space Medicine - Simulated hypogravity alters the angiogenic response of endothelial cells

Statins - Rosuvastatin, pravastatin, and atorvastatin do not affect clopidogrel efficacy

Stem Cell Research - Blood bank notes discovery of embryonic-like stem cells in umbilical cord blood

Stem Cell Research - Bmi-1 promotes neurogenesis by repressing P16Ink4a/P19Arf senescence pathways

Stem Cell Research - CD144 is transiently expressed by fetal liver hematopoietic stem cells

Stem Cell Research - Complications endure after stem cell transplants in patients with hepatitis B

Stem Cell Research - Embryonic stem cell lines generated from poor quality day 3 embryos

Stem Cell Research - Ink4a and Arf differentially affect cell proliferation and NSC self-renewal

Stem Cell Research - Interleukin-4 effects on intestinal mast cell functions are reversible

Stem Cell Research - Intestinal mast cell growth/phenotype/function tightly regulated by TGF-beta1

Stem Cell Research - Monoclonal side population progenitors isolated from fetal pancreas

Stem Cell Research - Osteopontin negatively regulates stem cell pool size

Stem Cell Research - P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression

Stem Cell Research - Skeletal muscle has been generated from transplanted embryonic stem cells

Stem Cell Transplantation - Donor CD31 codon 125 genotype correlates with acute GVHD incidence in HSCT

Stem Cell Transplantation - KIR genotype protects against leukemic relapse after related HLA-identical HSCT

Stem Cell Transplantation - Leaving central vein catheters in place does not increase SCT-related morbidity

Stem Cell Transplantation - Noninvasive oral rinse monitors neutrophil tissue delivery timing in SCT

Stroke - Study examined survival rates in HD patients who experience stroke

Thioredoxin - Thioredoxin studied in human cells

Thromboembolism - Hip fracture patients have a high risk of postoperative morbidity and mortality

Thrombosis - Catheter tip position implicated as risk factor for thrombosis

Tissue Engineering - Bone is formed by hMSCs in biodegradable scaffolds that release Dex/AsP

Tissue Engineering - Data advance knowledge in tissue engineering research

Tissue Engineering - Tissue engineered ceramic artificial joint used to treat osteoarthritis

Tissue Engineering - Tissue engineering techniques used for rotator cuff regeneration

Transplant Medicine - Edaravone reduces cold I/R injury in canine renal autografts

Transplant Medicine - Incidence of OPLC among patients estimated after liver transplantation

Transplant Medicine - Lung preservation assessed, role of surfactant protein A revealed

Tuberculosis Risk Factors - HLA haplotypes related to tuberculosis risk or resistance

Type 1 Diabetes - Study on diagnosing preclinical type 1 diabetes published in journal

Vaccine Vector - Transcription of self-inactivating lentiviral vectors examined

Vinorelbine - Vinorelbine combined with gemcitabine in previously treated SCLC patients

West Nile Virus - Recent findings illuminate research in west nile virus

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