Stem Cell Transplantation
Donor cell allodepletion may reduce severe acute GVHD rate in older patients
Published in Hematology Week, September 19th, 2005
"We have selectively depleted host-reactive donor T cells from peripheral blood stem cell (PBSC) transplant allografts ex vivo using an anti-CD25 immunotoxin.
"We report a clinical trial to decrease graft-versus-host disease (GVHD) in elderly patients receiving selectively depleted PBSC transplants from HLA-identical sibling donors," scientists writing in the journal Blood report.
"Sixteen patients (median age, 65 years [range, 51-73 years]), with advanced hematologic malignancies underwent transplantation following...
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Source: Hematology Week (2005-09-19)
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