Stem Cell Transplantation

Timing of TGF-beta neutralization is important for preventing GVHD after SCT

Published in Hematology Week, November 14th, 2005

The timing of TGF-beta neutralization is important for the prevention of graft-versus-host disease following stem cell transplantation.

According to a study from Australia, "Donor treatment with granulocyte-colony-stimulating factor (G-CSF) attenuates the ability of donor T cells to induce acute graft-versus-host disease (aGVHD) but increases the severity of chronic GVHD (cGVHD).

"We investigated the role of the regulatory cytokine transforming growth factor beta (TGF-beta) in this paradox in well-established murine models of aGVHD and cGVHD wherein recipients undergo transplantation with splenocytes from donors treated with G-CSF."

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Source: Hematology Week (2005-11-14)

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