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Hematology Week

Susan Hasty, Publisher

Table of Contents . . . November 21st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Hematology Week | Other Publications

Coronary Artery Bypass - Hemodilution and surgical hemostasis strongly influence transfusion need

Stem Cell Transplantation - ACE gene D-allele associated with noninfectious pulmonary dysfunction development after HSCT

Stem Cell Transplantation - Glutamine reduces the severity of mucositis in children undergoing HSCT

Stem Cell Transplantation - IIVP salvage regimen yields high response rates before autologous stem cell transplantation

Surgical Technology - FGV is potentially less time-consuming than standard microsurgical vasovasostomy

Acute Myeloid Leukemia - Phase II study to evaluate Xanafide in combination with ara-C for secondary AML

Adverse Drug Reaction - Patients develop acute liver failure after receiving amoxicillin/clavulanate

Allergy & Immunology - Donor HLA alleles may control hepatitis C virus spread to liver grafts

Alzheimer Disease - High-resolution serum proteomic profiling developed for Alzheimer disease detection

Angiology - Cilostazol reduces risk of restenosis after percutaneous transluminal angioplasty

Angiology - Gene transfer stimulates neoangiogenesis in rabbit peripheral ischemia models

Diagnostics - New data illuminates research in diagnostics

Angiology - Low protein Z levels may be a risk factor in central retinal vein or artery occlusion

Angiology - Precise location and preferential conduction of interatrial electrical connections revealed

Angiology - The JAK2/STAT5 pathway maintains neovascular growth during oxygen deprivation

Angioplasty - Ischemic preconditioning may attenuate regional release of inflammatory markers

Apoptosis - Fluorescence-enhanced flow cytometry developed for screening of apoptotic statins

Apoptosis - Immunosuppression by morphine-induced lymphocyte apoptosis did not occur

Hematology - Researchers' findings advance hematology research

Atherosclerosis - Neovessel instability may cause intraplaque hemorrhage in atherosclerotic lesions

Biomedical Engineering - LC/electrospray tandem mass spectrometry quantitatively detects propiverine in plasma

Bladder Cancer - Research in bladder cancer provides new insights

Blood Safety - Study shows ligand technology effective in removing blood-borne TSE infectivity

Cancer Fatigue - Fatigue in cancer patients not related to changes in oxyhemoglobin dissociation

Leukemia - Studies add new findings to leukemia body of knowledge

Cancer Research - UVA and UVB induce melanoma-associated growth factors in fibroblasts

Cancer Risk Factors - Maternal history of miscarriage associated with increased risk of childhood AML

Cancer Therapy - Anticancer drug gets fast track for elderly with acute myelogenous leukemia

Cancer Therapy - Anticoagulant treatment improved survival in cancer patients

Cancer Therapy - Cost of epoetin alfa and darbepoetin alfa treatment in Sweden evaluated

Cancer Therapy - Modification of treatment protocols improved outcome of childhood leukemia

Leukemia - Studies describe new findings in leukemia research

Cardiology - Antibodies to heparin pose a risk of adverse events following cardiac surgery

Cardiology - Flow mediated dilation is associated with changes in coronary diameter and coronary blood flow

Cardiology - Natural history atherosclerosis study to examine vulnerable plaques

Cardiology - Research add new data to cardiology body of knowledge

Cardiovascular Research - Bone marrow-derived myofibroblasts are present in adult human heart valves

Cardiovascular Research - Myocardial tissue level perfusion often impaired in patients

Oncology - New data illuminates research in oncology

Cardiovascular Research - Postangioplasty stenting lowers reocclusion/restenosis risk and improves LV function

Cardiovascular Research - Secondary arteriovenous fistulas underused but highly effective after access failure

Chemotherapy - Chemotherapy induced toxic myelopathy

Chemotherapy - Dose-dense chemotherapy may be superior to CHOP for primary mediastinal large B-cell lymphoma

Chemotherapy - Early efficacy of epoetin alfa superior to darbepoetin alfa

Clinical Trials - Authorization granted for U.K. trial of hemoglobin glutamer in cardiac surgery

Oncology - Researchers provide details of new studies and findings in the area of oncology

Collaborations - NAT maker to collaborate with Molecular Profiling Institute to bolster oncology strategy

Collaborations - Strategic agreement extended to discover blood diagnostics for cancer detection

Colon Cancer - Aberrant cytochrome c oxidase subunit I expression is biomarker for increased colon cancer risk

Colon Cancer - Scientists develop colon cancer blood test by quantifying cancer gene mutations

Complementary & Alternative Medicine -  Centella asiatica extract protects mouse hepatocytes from gamma ray induced changes

Coronary Artery Bypass - Canadian man has first minimally invasive robot-assisted double bypass surgery

Coronary Artery Bypass - Common carotid intima-media thickness doesn't predict secondary cardiovascular events

Coronary Artery Bypass - Radial artery harvesting doesn't cause neurologic hand dysfunction

Coronary Artery Bypass - Researchers provide details of new studies and findings in the area of coronary artery bypass

Coronary Artery Bypass - Triple-site triggered atrial pacing reduces risk of post-CABG atrial fibrillation

Coronary Artery Disease - Recent findings illuminate research in coronary artery disease

Cytotoxicity - Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of acute myeloid leukemia

Diagnostics - Benzodiazepines detected in human plasma and oral fluid using novel method

Diagnostics - Biochemical marker health assessment tool now widely available

Diagnostics - Blood bank safety advanced with U.S. launch of hepatitis test

Diagnostics - Capillary electrophoretic method detects glycolysis metabolites in human red blood cells

Diagnostics - D-dimer diagnostic test more accurate than computerized strain gauge plethysmography

Diagnostics - Diagnostics company launches homocysteine on its BN systems

Diagnostics - Findings in diagnostics provide new insights

Diagnostics - MRI of axial skeleton enabled objective measurement of tumor response

Diagnostics - Novel system enables in vivo analysis of bileaflet prosthesis leakage jet turbulence

Disease Associations - Factor V Leiden homozygosity does not influence dyspnea and reduced pulmonary function

Disease Associations - Neonatal repair of tetralogy of Fallot results in improved pulmonary artery development

Drug Development - Phase I study results of BLX-883 in hepatitis patients support continued development

Drug Safety - High doses of ibuprofen can cause significant GI bleeding despite its safety profile

Embolism - Cerebral embolism occurred after transcatheter arterial chemoembolization

Endocrinology - Neuroblasts migrate in response to endothelin-1 through involvement of endothelin type B receptors

Finance - Antibody-based drug developer reports net loss; initiates clinical trial

Finance - Biomedical testing company closes $15 million placement with private investors

Finance - Cancer vaccine maker records loss of $0.60 per share

Finance - Grants support hemophilia advocacy efforts

Finance - Leukemia drug developer reports loss of $0.29 per share, reports clinical pipeline update

Finance - Maker of cardiovascular-disease-related products completes US$6 million private placement

Finance - Phase III trial of leukemia vaccine raises $14 million

Fitness & Wellness - Exercise capacity in patients with beta-thalassemia intermedia is not significantly affected

Genetics - An XPNPEP2 variant is associated with induced angioedema

Genetics & Genomics - Chromosomal changes used to identify non-MALT marginal zone B-cell lymphomas

Genetics & Genomics - Cooperating cancer genes identified by oncogenic-retrovirus-induced mutagenesis

Genetics & Genomics - Pentameric symmetry loss in CRP induces IL-8 secretion through peroxynitrite signaling

Genetics & Genomics - Platelet glycoprotein IIIa genotype determines effect of aspirin on postoperative bleeding

Graft-versus-Host Disease - Interleukin-4-producing CD8+ cells may be an immunological hallmark of chronic GVHD

Granulocytic Sarcoma - Granulocytic sarcoma manifested as multiple skeletal lesions

Heart Failure - Cardioprotection may be beneficial in the management of acute heart failure syndromes

Hematology - Hemophiliacs respond satisfactorily to chronic hepatitis C therapy

Hematology - Hepatitis C virus infection may be associated with thrombocytopenia

Hematology - Reports describe recent advances in hematology research

Hematology - Thromboembolism complications increase following heart transplantation

Hemodialysis - Access site reuse preferable to de novo placement for conversion to permanent catheters

Hemophilia - Hemophilia organization announces two fellowships in bleeding disorders research

Hepatitis C Virus - Core-specific precursor T cell response reflects viral load in chronic hepatitis C

Hepatocellular Carcinoma - Findings in hepatocellular carcinoma provide new insights

Hypertension - Hypertension has unexpected beneficial effect on femorofemoral bypass graft patency

Hypoxia - Hypoxia delays the ontogeny of cardiovascular control in zebrafish

Hypoxia - Supercooling varies glycogen, free glucose, and lactate in organs of Chrysemys picta

Imaging - Sixteen-slice multidetector-row CT useful in determination of coronary artery lumen diameter

Imaging - Sonography can detect trisomies and other chromosome abnormalities

Influenza - Children with neurological and neuromuscular diseases should receive annual flu shot

Information Technology - Software for blood donor centers offers selective reporting of parameters

Ischemia - Heat stress increases the effectiveness of early ischemic preconditioning in spinal cord protection

Ischemia - Livers retrieved with short warm ischemia times may be acceptable for transplantation

Ischemia - Localized ectopic waves are essential in the progression of ectopic activity

Ischemia - Thrombospondin-1 induction in rat myocardial infarction is accelerated by ischemia/reperfusion

Leukemia - Combination regimen shown effective in treating B-cell lymphocytic leukemia

Leukemia - Common genetic variants linked to infection risk in children undergoing therapy

Leukemia - Data advance knowledge in leukemia research

Leukemia - Pathogenesis and therapy of acute myelogenous leukemia discussed

Lipid Research - Expression of PXR antagonizes cholic acid-mediated changes in plasma lipoprotein profile

Medical Devices - Covered metallic stents optimal for gallbladder carcinoma patients

Medical Devices - Fenestrated endograft gets CE Mark approval for complex aortic aneurysms

Medical Devices - Fractional flow reserve is valid marker of stent restenosis severity

Medical Devices - Georgetown University Hospital acquires BVA-100 blood volume analyzer

Medical Devices - Prototype of non-invasive method to measure hematocrit is complete

Medical Devices - Stentless aortic bioprostheses have excellent hemodynamic performance

Medical Devices - ThromboCheck enables home monitoring of prosthetic valves via digital frequency analysis

Medical Devices - Vasotrac enables noninvasive BP monitoring during prone anesthesia in adolescents

Metabolism - Dietary iron deficiency induces ventricular dilation and mitochondrial ultrastructural aberrations

Myelodysplastic Syndromes - Pharma company seeking authorization to market Revlimid in European Union

Neovascularization - Granulocyte-colony stimulating factor augments bone marrow-induced neovascularization

Nephrology - Cavitation detected in pig kidneys during shock-wave lithotripsy

Nosocomial Infections - Vfend equals two-drug candidemia regimen, with fewer serious side effects

Oncology - Data advance knowledge in oncology research

Ophthalmology - Bevacizumab intravitreal injection may be treatment for macular edema from vein occlusions

Osteoarthritis - Blood-based osteoarthritis biomarker paper published

Pain Management - Flavonoid treatment has little impact on pain or bleeding after ambulatory stapled hemorrhoidopexy

Parkinson Disease - Stem cell implantation shows beneficial effect on Parkinson disease

Pediatric Cancer - Malfunctioning events and catheter-related infections occurred rarely

Peptides - An immunoluminometric assay can measure midregional proadrenomedullin in plasma

Peripheral Vascular Disease - Autologous cell implantation improves limb ischemia in patients with peripheral arterial disease

Pharmaceutical Research - Antibiotic daunomycin binds to human serum albumin at nonclassical drug binding site

Pharmacology - Microdialysis plus capillary electrophoresis detects trimebutine maleate in rabbit blood

Physiology - Osmosensitive mechanisms contribute to the water drinking-induced pressor response in humans

Prognostics - Circulating plasma cells predicted survival in patients with newly diagnosed multiple myeloma

Prognostics - Concentration of thymidine kinase 1 used as proliferation marker in solid tumors

Prognostics - ETV6/RUNX1 rearrangement indicated good prognosis

Prognostics - Imatinib-induced inhibition of ABL kinase activity predicted patient response

Prognostics - Serum amyloid A protein predicts complications in patients with acute myocardial infarction

Reproduction - Large-conductance K+ channels regulate basal uteroplacental blood flow in ovine pregnancy

Respiratory Medicine - Anticoagulant therapy reduces mortality risk

Spinal Cord Injury - Antibody to IL-6R suppresses secondary injury and glial scar formation in spinal cord injury

Stem Cell Disorders - Telomerase activity in MDS may be insufficient to compensate for telomere shortening

Stem Cell Research - Angiopoietin-2 stimulates endothelial progenitor cell migration

Stem Cell Research - Ascorbic acid promotes osteoclastogenesis from embryonic stem cells

Stem Cell Research - Chronic intrathecal injections of a large volume of fluid increase mast cells in the CNS

Stem Cell Research - ESCs generate progeny by microinsemination of male germ cells from chimeric mice

Stem Cell Research - Electromagnetic fields affect transcript levels of apoptosis-related genes

Stem Cell Research - Embryonic stem cells cocultured with Thy1-positive cells differentiate into hepatocytes

Stem Cell Research - Inflammatory endothelial cells disrupt the repair capacity of endothelial progenitor cells

Stem Cell Research - Neural stem cell differentiation is dependent upon endogenous caspase-3 activity

Stem Cell Research - Neuroprotection by stem cell factor in cortical neurons involves Akt and NF kappa B

Stem Cell Research - Repression of DNA replication licensing in quiescence is independent of geminin

Stem Cell Research - Stem cells may potentially be used to modify aging

Stem Cell Therapy - Infused mesenchymal stem cells enhance recovery from I/R-induced acute renal failure

Stem Cell Transplantation - Allogenic chimeric mouse model indicate some donor stem cells exist more than 6 months

Stem Cell Transplantation - Bone marrow remains a significant source of stem cells for autologous HSCT

Stem Cell Transplantation - Higher NK cell dose reduces nonrelapse mortality and infectious events after SCT

Stem Cell Transplantation - Increased DMSO concentration associated with toxicity in stem cell transplantation

Stem Cell Transplantation - Increased TNF levels associated with increased risk of CMV infection after AHSCT

Stem Cell Transplantation - Nonmyeloblative SCT costs the same as myeloblative SCT after considering price of complications

Stem Cell Transplantation - Oral mucosal pathology is common in pediatric patients with cGVHD after HSCT

Stem Cell Transplantation - Perception of problematic social support associated with poor survival after SCT

Stem Cell Transplantation - Prospective monitoring of TNF-alpha and IFN gamma predicts onset of GVHD after ASCT

Stem Cell Transplantation - Protein C levels during HSCT conditioning do not predict veno-occlusive disease

Stem Cell Transplantation - Risk/benefit ratios of GVHD/graft-versus-leukemia effect differ among diseases

Surgery - Clamping of the renal artery recommended during laparoscopic partial nephrectomy

Surgical Technology - 3D CT angiography of internal carotid artery facilitates endoscopic approach

Surgical Technology - Concomitant abdominal and thoracic endovascular repair feasible for multilevel disease

Surgical Technology - Ex situ resection techniques and liver autotransplantation discussed

Surgical Technology - Microkeratome with artificial chamber provides reliable thickness and low endothelial cell loss

Surgical Technology - Single-photon emission CT and balloon occlusion show comparable hypoperfusion

Surgical Technology - SmartSuction HARMONY surgical suction pump cleared by U.S. FDA

Thrombosis - Hemostatic risk factors in predicting arterial thrombotic events clarified

Tissue Engineering - Bioresorbable composites enable adequate suitable properties for bone tissue engineering

Tissue Engineering - Full-thickness cartilage defects of the femoral condyle repaired with implant

Tissue Engineering - Highly differentiated 3D tissues reconstructed by stacking layers of small hepatocytes

Tissue Engineering - Serum deprivation improves repopulation of acellular matrices with valvular interstitial cells

Transplant Medicine - Patients fare well without steroids after hepatitis C-related liver transplants

Transplant Medicine - Pig-to-nonhuman primate organ xenotransplantation reviewed

Transplant Medicine - Researchers report details of new studies and findings in the area of transplant medicine

Transplantation - Cold or heat shock does not improve skeletal myoblast engraftment in infarcted myocardium

Urology - Vascular endothelial growth factor enhances bladder acellular matrix graft regeneration

Varicose Veins - EVLT developer launches next-generation DELTA laser platform

Vascular Disease - Data indicate that adipose stem cells form blood vessels and improve blood flow

Vasculitis - Patients with hepatitis C-associated nerve lesions have altered immune response factors

Virology - Joint Nordic prospective study indicates HHV8 is not linked to multiple myeloma risk

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