Stem Cell Transplantation

Two activating donor KIRs protects against leukemic relapse after related HLA-identical HSCT

Published in Hematology Week, December 19th, 2005

Two activating donor killer cell immunoglobulin-like receptors protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation.

"Killer cell immunoglobulin-like receptors (KIRs) recognize different groups of Human Leukocyte Antigen (HLA) class I alleles and are expressed by natural killer (NK) cells and some T lymphocytes. NK cell cytotoxicity is triggered by failure to recognize the appropriate HLA class I ligand on target cells," researchers in Belgium report.

According to S. Verheyden and colleagues at the Vrije University of Brussels, "Recently, it has been shown that HLA class I ligand incompatibility in the...

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Source: Hematology Week (2005-12-19)

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