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Tissue Engineering

Bone marrow stromal cells are an alternative cell source for tissue-engineered bladder

Published in Hematology Week, December 19th, 2005

Bone marrow stromal cells are an alternative cell source for tissue-engineered bladder.

In a recent report, researchers in the United States conducted a study to "assess the potential use of bone marrow stromal cell (BMSC)-seeded biodegradable scaffold for bladder regeneration in a canine model, by characterizing BMSCs and comparing them to bladder smooth muscle cells (SMCs) by immunohistochemistry, growth capability, and contractility.

"Bone marrow was taken by direct needle aspiration from the femurs of five beagle dogs for the in vitro study. Mononuclear cells were isolated by Ficoll-Paque density gradient centrifugation and cultivated in medium...

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