Published in Hematology Week, December 19th, 2005
According to recent research published in the Journal of Cerebral Blood Flow and Metabolism, "The heme oxygenase (HO) enzymes catalyze the rate-limiting step in the breakdown of heme to iron, carbon monoxide, and biliverdin. A prior cell culture study demonstrated that deletion of HO-2, the isoform constitutively expressed in neurons, attenuated hemoglobin (Hb) neurotoxicity."
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