Hematology Week

Apoptosis - Doxorubicin induces apoptosis in germ line stem cells in the immature testis

Epistaxis - Arterial embolization is an effective treatment for severe epistaxis

Leukemia - Early allogeneic stem-cell transplantation used to treat leukemia

Obstetrics - Angiogenesis markers increase in pregnancy-induced hypertension

Stem Cell Transplantation - PBSC remobilization ensures rapid and safe engraftment for poor mobilizers

Acute Lymphoblastic Leukemia - European study confirms efficacy of clofarabine in pediatric patients with ALL

Acute Myeloid Leukemia - Acute myeloid leukemia blasts regularly express PRR1 and PRR2

Acute Myeloid Leukemia - Scientists may be able to use novel antibody to target specific cells leading to AML

Acute Myeloid Leukemia - Study of childhood AML yields 1-year survival rates of almost 90%

Adenovirus - Nonhuman adenovirus alters human memory T cells

Anemia - PBI-1402 phase I trial is complete and shows positive results

Oncology - Researchers' data advance oncology research

Angiology - Early post-op coagulation and fibrinolysis are linked to myocardial damage

Angiology - Findings in angiology provide new insights

Angiology - Mechanotransduction drives vascular development

Biomaterials - Silk implants form trabecular-like bone matrices in bioreactors

Biomedical Engineering - Researchers' work adds to Biomedical Engineering body of knowledge

Blood-Borne Pathogens - Perisinusoidal B cells in BM participate in T-independent response to blood-borne microbes

Transplant Medicine - Researchers detail new studies and findings in the area of Transplant Medicine

Bone Regeneration - The osteogenic potential of adipose-derived mesenchymal cells is maintained with aging

Breast Cancer - Oxidative stress implicated in breast cancer

Breast Cancer - Polymorphisms of the BRCA2 gene associated with breast cancer

Business & Finance - Biologics maker announces filing of application to appoint receiver and resignation of directors

Business & Finance - Research note issued on Callisto Pharmaceuticals

Business Update - Vasovist maker to reduce workforce

Cancer Diagnostics - Methods for enumerating circulating tumor cells in carcinoma patients compared

Cancer Gene Therapy - Combinatorial antiangiogenic gene therapy regresses tumors in glioblastoma

Cancer Research - Phase III data show Aranesp increases and maintains patient hemoglobin levels

Cancer Therapy - Advances in radiotherapy show benefit for elderly patients with leukemia and non-Hodgkin lymphoma

Cancer Therapy - Data supports potential clinical utility of GRN163L in patients with multiple myeloma

Cancer Therapy - Hematologic safety and tolerability of topotecan investigated

Cancer Therapy - Human acute lymphoblastic leukemia cells produce human pregnancy hormone hCG

Cancer Therapy - Positive AT-101 data presented in four posters at hematology meeting

Cancer Therapy - Positive PXD101 phase I results presented at the American Society of Hematology

Cancer Therapy - Quadramet/ bortezomib combo demonstrates broad anticancer activity in preclinical study

Cancer Vaccine - Herpes simplex virus type-1 amplicons linked to vaccine generation in lymphoblastic leukemia

Cancer Vaccines - New data illuminates research in Cancer Vaccines

Cardiac Papillary Fibroelastoma - Surgery used to treat cardiac papillary fibroelastoma

Cardiology - Metabolic syndrome or ISI_0,120 , but not HOMA-IR, predicted cardiovascular disease risk

Cardiology - New findings in the area of cardiology described

Cardiovascular Disease - B-type natriuretic peptide is a CV risk marker in chronic kidney disease

Cardiovascular Disease - HDL-C is a key predictor of risk and treatment benefit in people over 70

Cardiovascular Disease - Haplotypes in APOC3 gene, not APOA5 gene, increase susceptibility to MI

Cardiovascular Disease - On- and off-pump CABG yield similar patency rates

Cardiovascular Disease - Periodontitis is associated with atherogenic lipoprotein profile

Cardiovascular Disease - Task force supports more intensive LDL-cholesterol lowering

Cardiovascular Research - Hyperhomocysteinemia is a weak prothrombotic factor

Chronic Lymphocytic Leukemia - Drug for lymphocytic leukemia shown to be generally well tolerated and biologically active

Chronic Lymphocytic Leukemia - Phase II talabostat plus rituximab trial exceeds targeted 20% response rate in CLL patients

Colon Cancer - Anemia deemed poor predictor of right-sided colon cancers

Colorectal Cancer - DCs fused with colorectal cancer cells induce immunity against autologous tumor cells

Cord Blood - UCBT cures severe chronic active Epstein-Barr virus infection after double HSCT failure

Cord Blood - Unrelated cord blood transplant successful in children with Shwachman-Diamond syndrome

Diabetes Complications - Diabetic nephropathy progression is related to elevated dicarbonyl and oxidative stress

Diabetes Complications - MT-I+II-mediated antioxidant defense and its response to exercise are impaired in diabetics

Diabetes Complications - Thromboxane A₂ receptor antagonist prevents atherogenesis caused by diabetes mellitus

Diabetes Pathogenesis - Altered cardiac efficiency and substrate metabolism are seen in obese mouse hearts

Diabetes Pathogenesis - Common pathogenesis of hepatic steatosis and insulin resistance is discussed

Diabetes Pathogenesis - Lower muscle glucose uptake and higher muscle lactate release contribute to glucose control

Diabetes Pathogenesis - Renal cortex of streptozotocin-induced diabetic rats has lower nitric oxide levels

Diabetes Pathogenesis - Resistin is not associated with insulin sensitivity or the metabolic syndrome

Diabetes Pathogenesis - Studies add new findings to Diabetes Pathogenesis body of knowledge

Diabetes Therapy - Potential of sodium glucose cotransporter 2 inhibitors as antidiabetic agents is assessed

Diagnostics - Diagnostics company presents data on soon-to-be introduced assay for hematologic diseases

Diagnostics - Laparoscopic-guided liver biopsy safe and informative in pediatric HSCT

Diagnostics - Molecular end point can be a safe and effective tool for clinical decision making

Diagnostics - Recent findings in diagnostics described

Diet & Nutrition - Argan oil consumption may have antiatherogenic effect

Diet & Nutrition - Cardiovascular disease risk is improved in some men on low-fat and low-saturated-fat diets

Diet & Nutrition - Data predicts reduction in cardiovascular disease risk with the low-fat diet

Diet & Nutrition - Low calorie diet prevents diabetic nephropathy in the obese

Diet & Nutrition - Vitamin D is important for prevention of bone, heart, and autoimmune diseases

Disease Associations - Diabetes and atherosclerosis share vascular homeostasis and glucose metabolism

Disease Associations - Family history of hematopoietic malignancy related to higher risk of lymphoma

Disease Associations - Greater awareness needed for adverse impact of anemia on cancer patients

Disease Associations - Risk factors leading to hypercholesterolemia and colorectal cancer studied

Drug Development - 1,4-DHP derivative promotes DNA repair in cultured human cells

Drug Development - AMN107 can produce dramatic benefits in some forms of leukemia resistant to Gleevec

Drug Development - Eculizumab shows sustained improvements in hemolysis, transfusions in patients with PNH

Drug Development - Novel diaroylhydrazine ligands show promise as iron chelators

Drug Development - Proteasome inhibitors evaluated in lymphoid malignancies

Endotoxic Shock - Oral geranylgeranylacetone pretreatment improves rat survival after LPS injection

Fanconi Anemia - Assay established for complement assignments in FA patients

Finance - Hematology-focused biotech company obtains receipts for short-form prospectus

Gene Expression - Factor VIIa binding causes differential gene expression in macrophages

Gene Research - Carriers of lipoprotein lipase S447X variant show enhanced apoprotein B-48 clearance

Gene Research - Coronary microvascular endothelial cell growth regulates gene expression

Genetics & Genomics - Cyclin D1 polymorphism linked to risk of childhood acute lymphoblastic leukemia

Genetics & Genomics - GATA-1 and Oct-1 are required for expression of hemoglobin-stabilizing gene

Genetics & Genomics - RANTES gene variations predict cardiac mortality in diabetes hemodialysis patients

HIV/AIDS HAART - HAART associated with life-threatening maternal and fetal macrocytic anemia

Healthcare Costs - Itraconazole more cost effective than amphotericin B for systemic fungal infections

Heart Failure - Properties of cardiac muscle contribute to gender-related incidence and mortality of heart failure

Helicobacter pylori -  H. pylori eradication results in complete histological remission of MALT lymphoma

Hematology - Amifostine cuts vascular endothelial growth factor secretion in hemopoietic stem cells

Hematology - Studies suggest red blood cell transfusions may be unnecessary for all heart surgeries

Hemophilia - Study of Factor VIII demonstrates efficacy to prevent joint bleeding in hemophiliacs

Hemophilia Epidemiology - Report reviews demographics of hemophilia in developing countries

Hepatitis B Virus - New data illuminates research in Hepatitis B Virus

Hepatitis C Virus - Chronic viral hepatitis influences graft survival in renal transplant patients

Hepatitis C Virus Therapy - HCV cirrhotic patients safely treated after partial splenic embolization

Hepatitis D Virus - Hepatitis D virus screening serological test required

Hodgkin Lymphoma - Epstein-Barr virus is prognostic marker of survival after Hodgkin lymphoma

Human T Cell Leukemia Virus - Mutations in determinants of HTLV-1 Env SU do not prevent viral replication

Hypertension - Researchers' work adds to hypertension body of knowledge

Imaging - 3-D echo-guided beating heart surgery feasible in swine model