Chronic Myeloid Leukemia

BCR-ABL transcript level patterns after allograft is variable in chronic myeloid leukemia

Published in Hematology Week, July 31st, 2006

BCR-ABL transcript level patterns following stem cell transplantation is variable in patients with Philadelphia chromosome-positive chronic myeloid leukemia.

According to a recently published study from the United States, "We identified 243 patients with Philadelphia (Ph) chromosome-positive chronic myeloid leukemia (CML) who had BCR-ABL transcripts monitored by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) after allogeneic stem cell transplantation for a median of 84.3 months.

"Individual patients were regarded as having achieved molecular relapse (MR) if the BCR-ABL/ABL ratio exceeded 0.02% on 3 occasions or reached 0.05% on...

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Source: Hematology Week (2006-07-31)

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