Addiction Medicine

Cocaine unbalances endothelial tissue factor and tissue factor pathway inhibitor expression

Published in Hematology Week, July 31st, 2006

Researchers writing in the Journal of Molecular and Cellular Cardiology report, "Cocaine consumption can lead to myocardial infarction. Tissue factor (TF) has been implicated in acute coronary syndromes, and the balance of TF and tissue factor pathway inhibitor (TFPI) determines initiation of thrombus formation."

J. Steffel and colleagues at University of Zurich wrote, "This study was designed to investigate the effect of cocaine on endothelial TF and TFPI expression. Cocaine (10^-8-10^-5 mol/l) increased thrombin-induced TF expression by 24% at 10^-7 mol/l (p<0.001) without affecting basal TF expression. In contrast, cocaine...

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Source: Hematology Week (2006-07-31)

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