Hematology Week

Chronic Myeloid Leukemia - Dasatinib targets earlier progenitors than imatinib in primary chronic myeloid leukemia

Hematology - Peripheral artery disease patients improve lipid control with pharmacist-based management

Leukemia - Childhood leukemia risk linked to birth weight and maternal weight

Multiple Myeloma Therapy - Thalidomide analogue-induced neutropenia in multiple myeloma is linked to increase in neutrophils bearing CD64

Peripheral Blood - Donor peripheral blood enriched for memory TCD8+ cells compared to bone marrow grafts

Adverse Drug Reaction - Severe liver disease is associated with prolonged antiretroviral drug exposure

Allergy & Immunology - Allergic inflammation is modified by different bacterial ligands in a rhinitis model

Anemia - Colorectal cancer and anemia interact to increase angiogenesis and cancer proliferation markers

Anemia - Neose reports that NE-180 was well tolerated in clinical trial as treatment for anemia

Angiology - Abdominal aortic aneurysm repair is predominantly done using endovascular techniques

Angiology - Abdominal aortic surgery in children provides excellent quality of life

Angiology - Arteriovenous access-related ischemia is treated using a new technique

Angiology - Cardiopulmonary support-associated distal limb ischemia may be prevented by novel cannula

Angiology - Endoluminal therapy is effective in supra-aortic vascular occlusive disease

Angiology - Endovascular versus open mesenteric revascularization studied for mesenteric ischemia

Angiology - High tumor necrosis factor-alpha in diabetes after MI linked to endothelial dysfunction

Angiology - Liver histopathology in nonalcoholic fatty liver disease related to carotid atherosclerosis

Angiology - Off-pump CABG surgery hematologic complications are reduced with half-dose aprotinin

Angiology - Off-pump coronary artery bypass surgery results in better outcomes

Angiology - Percutaneous coronary intervention-associated bleeding risk is correlated with increased age

Angiology - Symptomatic and asymptomatic carotid stenosis is considered in review

Angiology - Vena cava filter that is long-duration and temporary is safe and effective

Angioplasty - Peripheral artery disease patients show prolonged inflammatory response after angioplasty

Antibacterial Agents - ALT plus systemic antibiotics are effective for IV catheter-related bacteremia

Antibiotics - Prophylaxis dermatologic surgery in wound infections may be overused

Apoptosis - Myocardial apoptosis after hypothermic circulatory arrest is attenuated by cobalt chloride pretreatment

Atherosclerosis - Acute coronary syndrome risk is linked to number of yellow plaques in coronary artery

Atherosclerosis - Carotid and femoral atherosclerosis progression is predicted by oxidized phospholipids

Atherosclerosis - Carotid plaque destabilization and rupture are marked by pregnancy-associated plasma protein-A

Atherosclerosis - Carotid stenosis progression is predicted by myeloperoxidase in states of low HDL cholesterol

Beta-Blockers - Some beta-blockers are effective reactive oxygen and/or reactive nitrogen species scavengers

Biliary Malignancy - Patients with biliary malignancy underwent reconstruction of the right hepatic artery

Biomedical Engineering - Polytetrafluoroethylene graft-associated neointimal hyperplasia is not prevented with perivascular dipyridamole

Biomedical Engineering - Stent coatings for 316 stainless steel are developed

Blood Banking - Embryonic stem cell loss during conventional freeze-thawing due to apoptosis

Blood Vessel Tissue Engineering - Artificial blood vessel was fabricated

Breast Cancer - Breast cancer therapy with radiation to carotid arteries does not increase risk of stroke

Business Update - Chembio submits CLIA Waiver Application for HIV 1/2 Stat Pak

Business Update - Concentric Medical announces release of next-generation ischemic stroke device in Europe

Business Update - Cook Zilver Vascular Stent receives U.S. FDA approval

Business Update - Dade Behring Sysmex CA-7000 Coagulation Analyzer now connects to StreamLAB Analytical Workcell

Business Update - El Camino Hospital opens first center devoted to heart disease prevention for South Asians

Business Update - EPIX Pharmaceuticals retains full rights to fibrin-binding imaging agent EP-2104R

Business Update - Ortec issues update on three technology platforms for regenerative medicine and stem cells

Business Update - Solvay welcomes Abbott, AstraZeneca plan to jointly develop single pill for lipid management

Business Update - Spectral Diagnostics' endotoxin activity assay system placed in two Italian hospitals

Cancer Gene Therapy - Antitumor responses generated by genetic modification of primary human T cells

Cancer Registries - Cancer incidence in patients with systemic sclerosis was higher than in the general population

Cancer Research - No complete remissions observed in study of alemtuzumab for leukemia patients

Cardiac Transplantation - Acute and chronic cardiac allograft rejection was prevented by pioglitazone

Cardiac Transplantation - Induction therapy post-heart transplantation with basiliximab is safer than muromonab

Cardiac Transplantation - Long-term heart preservation may be better with UW rather than Celsior solution

Cardiology - Aortic valve replacement results in impairment of aortic distensibility

Cardiology - Cardiac output estimation with a new Doppler device agrees with thermodilution technique

Cardiology - Elevated serum phytoestrogen levels are associated with more favorable lipoprotein profile

Cardiology - Endothelial function is improved in women consuming soya isoflavone-enhanced diet

Cardiology - Milrinone-vasopressin may be better for maintaining hemodynamics during coronary artery bypass graft

Cardiology - Transesophageal-guided cardioversion with anticoagulation is effective for atrial fibrillation

Cardiology - Transvenous lead systems implanted in children have similar incidences of venous occlusion

Cardiology - Triple valve surgery short- and long-term results have improved since 1990

Cardiology - Vascular function may not be improved by chronic consumption of red wine

Cardiovascular Disease - Cardiac surgery is associated with altered responses to postural change and exercise

Cardiovascular Disease - Coronary artery calcified plaque is strongly linked to clinical coronary heart disease

Cardiovascular Disease - Coronary artery disease extent is associated with elevated C-reactive protein levels

Cardiovascular Disease - Factors affecting delayed growth hormone deficiency were studied in adults

Cardiovascular Disease - Most adverse angiographic events during PCI predict adverse outcome within 6 months

Cardiovascular Disease - Retinal arteriolar and venular caliber is associated with cardiovascular risk factors

Cardiovascular Research - Antiplatelet therapy as adjunct to carotid stenting is reviewed

Cardiovascular Research - CABG surgery outcome can be predicted by preoperative severity of angina

Cardiovascular Research - Cardiac resuscitation using extracorporeal lung and heart assist may require systemic heparin dose

Cardiovascular Research - Cerebral endothelial nitric oxide synthase expression is reduced after very low flow bypass

Cardiovascular Research - Diastolic heart failure in hypertensive rats is linked to NADPH oxidase-mediated ROS production

Cardiovascular Research - Hypotension-induced vasopressin release is enhanced in hindlimb unloaded rats

Cardiovascular Research - Uric acid is a risk factor for myocardial infarction and stroke

Cellular Cardiology - Endotoxin-induced cardiac dysfunction is prevented by polyethylene glycol-superoxide dismutase

Cellular Cardiology - Vascular smooth muscle cell motility is controlled by sphingosine-1-phosphate-activated Ca channel

Cerebrovascular Disease - Prothrombotic risk factors may have a role in ischemic stroke and migraine in children

Chronic Myelogenous Leukemia - BCR-ABL is not an immunodominant antigen in chronic myelogenous leukemia

Clinical Trials - In-stent restenosis treatment with sirolimus-eluting stents yields superior outcomes

Colorectal Cancer - Fetal hemoglobin-blood cells developed within colorectal tumor tissues

Critical Care Medicine - Coronary artery bypass graft surgery patients can have PAC insertion delayed until clinical need

Critical Care Medicine - Mechanical ventilation weaning with an automated ventilator is comparable

Critical Care Medicine - OPCAB surgery patients who are low risk are sufficiently monitored by CVP

Cytomegalovirus & Lymphoma - Cytomegalovirus infection triggers lymphoma cell apoptosis in the liver

Diabetes & Angiology - Sirolimus-eluting stent implants effectively inhibit neointimal hyperplasia in diabetes

Diabetes Complications - Albuminuria and renal impairment are associated with distinct risk factors sets in diabetes

Diabetes Complications - Hyperglycemia stimulates coagulation but hyperinsulinemia impairs fibrinolysis

Diabetes Complications - Microalbuminuria and hypertension rates are higher in youth with type 2 diabetes

Diabetes Control - Glycemic control in type 1 diabetes may improve with better blood glucose event analysis

Diabetes Control - Insulin pump therapy improves glycemic control in youth with type 1 diabetes

Diabetes Pathogenesis - Dyslipidemia occurs more frequently in diabetes mellitus than in controls

Diabetes Pathogenesis - Mercury-induced oxidative stress and phosphoinositide 3-kinase promote beta-cell dysfunction

Diabetes Therapy - Atorvastatin lowered apolipoprotein A5 and triglycerides in type 2 diabetes

Diabetes Therapy - N-3 fatty acid supplements plus statin-fibrate lower homocysteine in diabetic dyslipidemia

Diabetes Therapy - Sulphonylurea affects myocardial glucose utilization regardless of glycemic control

Diabetes Therapy - Voglibose reduces oxidative stress markers and soluble adhesion molecules in obese diabetics

Diabetic Neuropathy - Prediabetic neuropathy improves after lifestyle intervention

Diagnostics - Coronary artery disease is weakly predicted by proton NMR analysis of plasma

Diagnostics - Fontan connection energy loss is primarily due to wall shear stress

Diet & Nutrition -  Lactobacillus-fermented milk decreases cholesterol levels

Diet & Nutrition - Baroreflex sensitivity improves after cashew nut-rich diet regardless of obesity change

Diet & Nutrition - Conjugated linoleic acid affects lipoprotein lipase and lipogenic enzymes in hamster model

Diet & Nutrition - Lipoprotein reductions reduce macrophage content in atherosclerotic lesions

Diet & Nutrition - Methionine content imbalance in maternal diet reduces postnatal growth in rat model

Drug Development - Novel synthesis of nicotinamide derivatives with cytotoxic properties described

Embryogenesis - Testis germline stem cell niche investigated during the late stages of embryogenesis

Embryonic Stem Cell Research - Damaged protein elimination occurs during embryonic stem cell differentiation

Embryonic Stem Cell Research - Sox3 labels specific stages of embryonic stem cell-derived neural progenitors

Endocrinology - Arterial stiffness is increased in subclinical hypothyroidism

Endocrinology - Glucose homeostasis markers in twins are similar to those found in type 2 diabetes

Environmental Risks - Risk factors determined for occupational blood and body fluid exposure in a hospital

Epidemiology - Prediction model of hepatocarcinogenesis validated

Finance - Nasdaq authorizes public trading of Stem Cell Authority Ltd.

Fitness & Wellness - Lifestyle changes lowered high-sensitivity C-reactive protein and improved weight

Gastric Ulcer - Gastric ulcer healing is hastened by platelets expressing angiogenic growth factor

Generic Drugs - U.S. FDA grants tentative approval for Teva to market generic Lotrel capsules for hypertension

Geriatrics - Mortality risk is predicted by interleukin-6 and carotid plaque number in old and very old men

Graft-versus-Host Disease - Lymphocyte function-associated antigen-1 functions in graft-versus-host disease

HIV/AIDS & Heart Disease - HIV/AIDS patients have modifiable risk factors for developing coronary heart disease

HIV/AIDS-Associated Hodgkin Disease - HAART improves survival in HIV-associated Hodgkin disease

Hematology - Antiplatelet therapy in secondary prevention for cerebrovascular disease patients is reviewed

Hematology - Hyperhomocysteinemia is presented in a review of its multiple roles

Hematology - Pathophysiological consequences of homocysteine excess are considered in review

Hematology - Thrombolysis is considered in a review of past, present, and future therapeutic contexts

Hematopoiesis - RAR gamma critical for maintaining balance between stem cell self-renewal and differentiation

Hematopoiesis - Video detects features of proliferating stem cells that are predictive of self-renewal divisions

Hepatitis C Virus - Chronic hepatitis C fibrosis is influenced by keratin variants

Hepatitis C Virus - Noninvasive index predicts significant fibrosis

Hepatology - Acute liver injury and vascular factors are linked in endotoxemic models

Hepatology - Cirrhotic cardiomyopathy is presented in review of clinical features, pathogenesis, and treatment

Hyperglycemia - Acarbose improves endothelial dysfunction in type 2 diabetes model

Hyperglycemia - Total parenteral nutrition in hematopoietic stem cell recipients was related to hyperglycemia

Hypertension - BMI can be an intermediate variable linking depression and hypertension symptoms

Hypertension - Peroxisome proliferator-activated receptors-gamma agonist action shows BP-lowering effects

Immunosuppression - Systematic review details limited sampling strategies for immunosuppressants

Infectious Diseases - Severe sepsis exacerbates cell-mediated immunity in the lung

Kaposi Sarcoma - Peripheral blood dendritic cells and their precursors altered in classic Kaposi sarcoma

Kidney Disease - Renal angiomyolipomas with minimal vascularity do not require prophylaxis

Leukemia - FHIT gene therapy using chimeric adenovirus shows promise for leukemia

Leukemia - Philadelphia chromosome-positive leukemia treated with dasatinib

Lipid Research - Adiponectin in umbilical cord blood is inversely related to LDL-cholesterol but not ethnicity

Market Analysis - Report addresses hypertension therapy market

Mental Health - Depression in older age is a risk factor for first ischemic cardiac events

Mergers & Acquisitions - W. L. Gore & Associates acquires medical device company Neural Intervention Technologies

Myeloma - Revlimid in combination with dexamethasone approved by U.S. Food and Drug Administration

Myocardial Infarction - Heart attack risk is higher in women with elevated von Willebrand and procoagulant factors

Myocardial Infarction - Ischemic colitis associated with MI may be due to hypotension from cardiogenic shock

Natural Products - Antidyslipidemic activity is shown by furano flavonoids isolated from Indigofera tinctoria

Natural Products - Chlorogenic acid attenuates hypertension and improves endothelial function in rats

Natural Products - Lipid lowering activity of Eclipta prostrata in hyperlipidemia is reported

Neural Stem Cell Research - SDF1 alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in neural progenitors

Neurogenesis - Dexefaroxan enhances hippocampal neurogenesis

Neurogenesis - Fluoxetine targets early progenitor cells in the adult brain

Norwalk Virus Transmission - Oysters selectively concentrate norovirus particles

Obesity & Atherosclerosis - Weight loss reduces plasma endothelin-1 concentration in obese men

Obesity & Coronary Heart Disease - Obesity may modify the link between hepatic lipase gene and coronary heart disease risk

Obesity Complications - AdipoR1 expression in intra-abdominal adipose tissue was not altered by obesity or diabetes

Obesity Pathogenesis - Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis

Obstetrics - Presence of sickle cell trait increases risk of fetal loss in women

Occupational Exposure - Incidence of leukemia, lymphoma, and multiple myeloma in Czech uranium miners studied

Oncology - Tumor angiogenesis is enhanced by hematopoietic cells

Patents - Critical Therapeutics announces U.S. patent relating to HMGB1 for arthritis and lupus diagnostics

Patents - Medwave granted five new patents on blood pressure monitoring technology

Patents - Pharming strengthens intellectual property position for recombinant human C1 inhibitor

Pediatric Cardiology - Coagulopathy and inflammation in neonatal heart surgery are focus of review

Pediatric Cardiology - Native aortic root thrombosis in hypoplastic left heart syndrome is rare but life threatening

Pediatric Helicobacter Pylori & Cancer -  Helicobacter pylori cause of gastrointestinal disease in children with hemato-oncologic disease

Pediatric Stem Cell Transplantation - Cidofovir safe and effective for adenoviral infection in pediatric stem cell transplantation

Peptic Ulcers - Bleeding ulcer treatment with transcatheter arterial embolization is facilitated

Personnel - Life Therapeutics appoints Subhash C. Sarda as CEO

Phosphodiesterase Inhibitors - Vardenafil administration combined with alcohol shows no interaction in healthy males

Portal Hypertension - Portal hypertension models show how heme oxygenase-1 renders positive and negative effects

Primary Aldosteronism - Primary aldosteronism is associated with partially reversible renal dysfunction

Prostatic Hyperplasia - Serum lipid levels and I-PSS or Qol are not linked in prostatic hyperplasia

Proteomics - Cardiac fibrosis induced by urokinase plasminogen activator requires plasminogen

RNA Research - RNA transfection allows investigation of endothelin posttranscriptional regulation

Renal Cell Carcinoma - Renal cell carcinoma management with contemporary techniques and cardiovascular procedures evaluated

Renal Disease - Acetate-free biofiltration reduces intradialytic symptoms and improves quality of life

Respiratory Medicine - Degranulation of human leukocytes inhibited by a peptide