Stem Cell Research
Airway epithelia differentiation dependent on erbB2
Published in Hematology Week, September 11th, 2006
"A clinical case documented a reversible change in airway epithelial differentiation that coincided with the initiation and discontinuation of trastuzumab, an anti-erbB2 antibody.
"This prompted the investigation into whether blocking the erbB2 receptor alters differentiation of the airway epithelium," wrote investigators in the United States.
According to P.D. Vermeer and colleagues at the University of Iowa, "To test this hypothesis, we treated an in vitro model of well-differentiated human airway epithelia with trastuzumab or heregulin-alpha, an erbB ligand.
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Source: Hematology Week (2006-09-11)
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