Hematology Week

Atherosclerosis - Symptomatic and asymptomatic atherosclerotic carotid plaque features were compared with in vivo MR imaging

Drug Development - High-throughput screen is developed for soluble epoxide hydrolase inhibition

Neonatal Leukemia Treatments - Treatment outcomes improved in neonatal leukemia in Japan

Progenitor Cells - Hyperglycemia accelerated EPC senescence by p38 mitogen-activated protein kinase activation

Adipose Tissue - Cold exposure stimulates synthesis of bioactive lipid oleoylethanolamide in adipose tissue

Alzheimer Disease - Selective Alzheimer Disease Indicator-1 gene abundantly expressed by stem cells

Anemia - Advanced Magnetics completes enrollment in two phase III studies of Ferumoxytol for anemia

Anemia - Biopure's application for Hemopure accepted for review in United Kingdom

Anemia - Researchers find a relationship between anemia and impaired thinking

Anesthesia - Myocardial protection during CABG surgery may be provided by volatile anesthetic agents

Angiology - Bare-metal stent restenosis rates are lower in an unselected patient population

Angiology - Bezafibrate shows anti-atherosclerotic, anti-hypertension benefits beyond lipid lowering

Angiology - Carotid angiography can be performed by vascular surgeons on a routine basis

Angiology - Carotid artery angioplasty with stenting versus carotid endarterectomy is studied

Angiology - Carotid stenting-associated intraprocedural bradycardia is studied

Angiology - Childhood C-reactive protein values predict adult values independent

Angiology - Coronary anastomoses using different adhesives are evaluated

Angiology - Endothelial function is impaired in patients with myocardial bridge

Angiology - Hepatic function recovery lags after hepatic volume changes due to portal vein ligation

Angiology - Lost coronary stent long-term consequences are assessed

Angiology - Protected carotid stenting in high-surgical-risk patients is safe and effective

Angiology - Single-ventricle patients with shunt or conduit obstruction are treated using stenting

Angiology - Stent deployment to repair aortic coarctation is feasible under MR guidance

Antitumor Therapy - Recurrent gastrointestinal stromal tumors in complete remission after imatinib treatment

Apoptosis - Azidothymidine in adult T cell leukemia/lymphoma patients results in tumor cell death

Apoptosis - Pinusolide evaluated for its antileukemic potential

Artificial Blood - Leech behavior modified following foraging for artificial blood

Atherosclerosis - Atherosclerotic plaque stability is affected by novel candidate genes

Atherosclerosis - Cardiac biomarkers in atherosclerotic disease prediction and diagnosis are focus of review

Atherosclerosis - Links between inflammation and thrombogenicity in atherosclerosis are reviewed

Atherosclerosis - Preclinical atherosclerosis prevalence may help explain education differences in coronary morbidity

Biosynthesis - Cholesterol biosynthesis disorders are influenced by precursors that alter cell rafts and function

Blood Safety - Antihemophilic factor concentrates are not without risk

Blood Safety - Pall System to detect bacteria in red blood cells granted CE Mark

Blood Safety - Pathogen safety reconfirmed for Prolastin

Blood Safety - Precautions necessary during hand surgery on patients at high-risk for blood-borne viruses

Blood Safety - Safety concerns over the Canadian blood supply drives patients to autodonate

Blood Safety - Simian foamy virus infection occurred by whole-blood transfer in rhesus macaques

Body Mass Index - Bupropion plus low-key dietary intervention reduce olanzapine-associated weight gain

Breast Cancer - Breast cancer-specific mRNA transcripts after adjuvant chemotherapy predicts poor survival

Business & Finance - Haemacure reports third quarter revenues of $31,409 and updates Hemaseel project

Business Update - Aida Pharmaceuticals provides update on Rh-Apo2L in lymphoma

Business Update - Amgen launches Aranesp prefilled SureClick Autoinjector to treat anemia

Business Update - Deltex Medical new trial data show CardioQ reducing duration of hospital stays by one-third

Business Update - Lifeblood Medical establishes Cell Preservation Solutions, LLC as a wholly owned subsidiary

Business Update - Medical Simulation Corporation launches online course on hemodynamic monitoring

Cancer Immunotherapy - FcR gamma expression not required for HeFi-1-mediated tumor growth inhibition

Cancer Marker - p16INK4 overexpression is a reliable marker of HPV-induced oral high-grade squamous dysplasia

Cancer Pharmacogenomics - Genomics used to predict response to chemotherapy

Cancer Therapy - Single-dose pegfilgrastim induces stem cell mobilization in malignant lymphoma or multiple myeloma

Cancer Therapy - Tumor angiogenesis is limited by promyelocytic leukemia tumor suppressor

Cardiac Medical Devices - Conor Medsystems announces two-year follow-up data from EuroSTAR pivotal study

Cardiac Medical Devices - Data suggest CYPHR Sirolimus-eluting Coronary Stent compares favorably to bare metal stents

Cardiac Medical Devices - Trial follow-up data show positive outcomes at 4 years for paclitaxel-eluting stent system

Cardiac Medical Devices - Two-year data suggest Cypher, Taxus stents have different blood clot and heart attack rates

Cardiac Medical Devices - U.S. FDA approves first totally implanted permanent artificial heart for humanitarian uses

Cardiology - Atrial exclusion device allows rapid and safe left atrial appendage exclusion

Cardiology - Cardiac effects of enzyme replacement therapy for mucopolysaccharidosis probed

Cardiology - Epicardial microwave ablation for atrial fibrillation is dependent on cardiac output

Cardiology - Nuvelo completes enrollment in Phase III trial of alfimeprase in acute arterial occlusion

Cardiology - Percutaneous mitral annuloplasty devices may work by indirect traction

Cardiology - Preoperative statin therapy is associated with reduced cardiac mortality

Cardiology - Published study shows enoxaparin safer than heparin in elective PCI or coronary angioplasty

Cardiology - Pulmonary artery catheter insertion lengths are determined

Cardiology - Rapid pacing facilitates transcatheter prosthetic heart valve implantation

Cardiology - Recombinant factor VIIa use in cardiac surgery produces no adverse effects

Cardiology - Single-ventricle physiology effects on myocardial blood flow are studied

Cardiovascular Disease - Aorta valve stenosis may be driven by elastolytic cathepsins

Cardiovascular Disease - C-reactive protein linked to cardiovascular disease in people with diabetes

Cardiovascular Disease - Coronary artery disease patients show increased plasma concentrations of matrix metalloproteinase-7

Cardiovascular Disease - Evaluation, treatment of ischemic cardiac risk before and after renal transplantation are examined

Cardiovascular Disease - In type 2 diabetes, chronic kidney disease was associated with increased artery stiffness

Cardiovascular Disease - Low-density lipoprotein cholesterol, statins, and cardiovascular events are focus of meta-analysis

Cardiovascular Disease - Lower cardiovascular disease event risk is associated with higher serum estradiol level

Cardiovascular Disease - Microalbuminuria and risk for cardiovascular disease are reviewed

Cardiovascular Disease - Olive constituent is anti-ischemic, antioxidative, and hypolipidemic

Cardiovascular Disease - Vascular disease pathogenesis may involve smooth muscle precursor cells in circulating human blood

Cell Transplants - Reduced survival after HLA-identical SCT may be caused by pre-existing viral infections

Cerebrovascular Disease - Patent foramen ovale and cerebrovascular diseases are considered in review

Cervical Paraganglioma - Cervical paraganglioma-related neurological deficits prevented by early management

Clinical Trials - ACE inhibitors in stable vascular disease reduce serious vascular events

Clinical Trials - Cardiovascular disease clinical trials' efficacy and safety are discussed

Clinical Trials - Lipid-lowering therapy and LDL-cholesterol targets are reviewed in update of clinical trial data

Colon Cancer - IL-11-receptor alpha-protein expression decreased in colon carcinoma

Colorectal Cancer - Colorectal cancer treatment with nadroparin was safer than enoxaparin in terms of bleeding risk

Colorectal Cancer - Isolated tumor cell status in regional lymph nodes correlates with colorectal cancer stage

Complementary & Alternative Medicine - Triptolide displayed potent antileukemic activity

Critical Care Medicine - Cardiac output with the PiCCO system can use femoral or radial arterial input

Critical Care Medicine - Cardiovascular function after trauma is less impaired with rapid control of bowel perforations

Critical Care Medicine - Impedance cardiography is comparable to thermodilution for cardiac output assessment

Depression - Fatty acids of adipose tissue better predict depression than those of cholesteryl esters

Diabetes & Obesity - Atherosclerosis related gene identified in LDL receptor-deficient C57BL/6 mice

Diabetes & Obesity - Reduced cardiac efficiency in obesity and diabetes is reviewed

Diabetes Complications - Blood flow velocity reduction may raise retinal thickness of macula in diabetic macular edema

Diabetes Control - Type 1 diabetes glucose control with insulin reduces blood cell binding activity

Diabetes Pathogenesis - Beta cell compensation for insulin resistance is related to lipolysis and fatty acid signaling

Diabetes Pathogenesis - Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA

Diabetes Pathogenesis - Early alterations in myocardia and vessels of diabetic rat hearts are investigated

Diabetes Pathogenesis - Free fatty acids inhibit vascular insulin signaling and eNOS activation

Diabetes Pathogenesis - In diabetes, endothelial dysfunction of cerebral arterioles requires NO synthase expression

Diabetes Pathogenesis - Insulin regulation of muscle PDK4 mRNA expression impaired in acute insulin-resistant states

Diabetes Prevention - Antidiabetic mechanisms are instigated by supranutritional selenate

Diabetes Therapy - Berberine activates AMPK with beneficial metabolic effects in diabetic and insulin-resistant

Diabetes Therapy - Hyperglycemic impairment is counteracted by benfotiamine

Diabetes Therapy - Intrahepatic transplanted islets secrete insulin in coordinate pulsatile manner to the liver

Diabetes Therapy - The antidiabetic drug FPFS-410 is limited in bioavailability by bile acids

Diabetes Therapy - Thiazolidinedione reverses low fatty acid oxidation and high lipogenesis in obese diabetics

Dialysis - Enoxaparin pharmacokinetics do not correlate with its effect in patients on dialysis

Drug Development - Animal research results show nutmeg extracts illicit anti-diabetic activity in rats

Drug Development - Atherosclerosis reduction may be benefit of combination treatment with CETP inhibitors, statins

Drug Development - Ovation and Cardinal Health announce plans to manufacture Panhematin

Dyslipidemia - Contemporary dyslipidemia management in high-risk patients is suboptimal

Embryonic Stem Cell Research - Magnetically labeled embryonic stem cells tracked both in vitro and in vivo

Environmental Health - Cyanobacterial toxins in water supplies should be examined for carcinogenicity

Environmental Health - Heart rate variability in older CAD disease subjects is adversely affected by course particles

Esophageal Leiomyoma - Esophageal tumor exposed by transecting right superior intercostal vein

Facilities - Bio-Matrix Scientific issues update on stem cell cryogenic banking facility

Finance - Dynavax secures equity financing commitment of up to $30 million

Finance - ThermoGenesis Corp. reports Q4 2006 net revenues up 14.8% over year ago to $3,557,000

Gastric Cancer - Oncogenic T-antigen of JC virus is frequently present in gastric cancers

Genetics & Genomics - Atherothrombosis may involve prostaglandin-E receptor-2 gene variation

Genetics & Genomics - Cardiovascular disease in dialysis patients is predicted by haplotype of STAT3 gene

Genetics & Genomics - Familial hypoalphalipoproteinemia expression is influenced by promoter haplotype of ABCA1 mutant

Genetics & Genomics - Hematopoietic cell proliferation may be mediated by protein modulation

HIV & Venous Thrombotic Events - Venous thrombotic events in HIV patients are due to abnormalities of protein S and factor VIII

Heart Disease - Microalbuminuria predicts more severe angiographic coronary artery disease

Heart Failure - Oxidative stress in aldosteronism is considered within context of congestive heart failure

Heart Failure - Percutaneous mitral annular reduction therapy for functional mitral regurgitation is studied

Hematology - Anemia raises cardiovascular disease risk in patients with elevated serum creatinine

Hematology - Chronic inflammation tied to Chlamydia pneumoniae infection is present in atomic bomb survivors

Hematology - Long-term intensive plasmapheresis donors can safely donate 850 ml plasma up to 60 times/yr

Hematology - New tool helps blood specialists improve patient care

Hematopoiesis - Cytokines induce megakaryocytopoiesis and thrombopoiesis from X-irradiated stem cells

Hemochromatosis Screening - Screening for hereditary hemochromatosis reviewed

Hemophilia - Pediatric hemophilia quality of life outcomes assessed by CHO-KLAT

Hepatitis B Virus - Hepatitis B virus-specific cytotoxic T cells analyzed in acute infection

Hepatitis C Virus - Chronic hepatitis C virus may involve hepatic progenitor cells

Hepatitis C Virus - Hepatitis C and hepatitis B virus risk due to cosmetic procedures clarified

Hepatitis C Virus - Hepatitis C interferon treatment transcriptional response is modified by race

Hepatitis C Virus - Hepatitis C virus-positive liver transplant patients may not benefit from treatment withdrawal

Hepatitis C Virus - Iron accumulation in hepatitis C is influenced by Helicobacter pylori

Hepatocellular Carcinoma - Hepatitis C virus-related hepatocellular carcinoma clinical features clarified

Hepatocellular Carcinoma - Human hepatocellular carcinomas display decreased expressions of hepsin

Imaging - Calcium scoring, contrast-enhanced CT angiography has potential to replace invasive angiography

Imaging - Peripheral arterial occlusive disease can be evaluated accurately by moving-table MR angiography

Immunomodulator - Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation

Infectious Diseases - Nosocomial infections in a Respiratory Intensive Care Unit are studied

Insulin Resistance - Long-term interleukin-1 beta treatment induces insulin resistance in human adipocytes

Insulin Resistance - Pioglitazone restores HSP72 and tolerance against ischemia/reperfusion injury in rat model

Invasive Aspergillosis Therapy - Antifungal therapy not warranted at initial invasive aspergillosis diagnosis

Ischemia - Myocardial ischemia-reperfusion injury is limited by hydrogen sulfide production

Ischemia - Post ischemia renal interstitial fibrosis is regulated by chemokine receptor

Kaposi Sarcoma Therapy - Kaposi sarcoma effectively treated with 8 Gy single-dose radiotherapy

Kidney & Cardiovascular Disease - Myocardial perfusion defect and CRP signal atherosclerosis progression in hemodialysis patients

Kidney & Cardiovascular Disease - Plasma lipoprotein abnormalities in hemodialysis patients are focus of review

Kidney & Cardiovascular Disease - Prognosis of hemodialysis patients with coronary artery disease could be improved with intervention

Kidney Disease - Experimental glomerulonephritis models benefit from mesenchymal stem cell transplantation

Legal Issues - International Trade Commission rules in Roche's favor

Leukemia - Acute myelogenous leukemia remission should be confirmed by FISH

Leukemia - Leukemia antiproliferation and apoptosis induced by C-glycosides

Leukemia - Leukemia chemotherapy efficacy evaluated by minimal residual disease measurement

Leukemia - Leukemia p53-mediated apoptosis induced by Mdm2 inhibitor Nutlin-3a

Leukemia - Leukemia prognosticated by ZAP-70 protein expression

Leukemia - Leukemia resistance to glucocorticoid not related to inability to up-regulate glucocorticoid receptor expression

Leukemia - Leukemia response to chemotherapy predicted by CASP8AP2 expression

Leukemia - Leukemia risk in children with Down syndrome linked to household chemical exposure

Leukemia - Pediatric leukemia treated by home-based chemotherapy might be feasible

Leukemia - T cell acute lymphoblastic leukemia/lymphoma target identified

Licensing Agreements - SurModics and X-Cell Medical sign license agreement for drug eluting stent development

Lipid Metabolism - Conjugated docosahexaenoic acid inhibits lipid accumulation in rats

Lipoproteins - Lipoprotein lipid hydroperoxide sequestering peptides release HLDL-related antioxidant enzymes

Liver Disease - Toray, JT, Torii agree to co-develop antipruritus drug for hepatic disease patients in Japan

Lung Cancer - Cytostatic lung perfusion results in high overall drug uptake by the lung

Lung Cancer - Herbal mixture downregulates COX-2 nonsmall cell lung cancer cells

Lung Cancer - Lung cancer response and progression predicted by D-dimer plasma levels

Malaria - Pasteur Institute scientists report discovery of malaria parasite

Medical Devices - Masimo Rainbow SET Pulse CO-Oximetry technology receives medical design award

Melanoma - Melanoma growth and metastasis increase with excess placenta growth factor expression

Mergers & Acquisitions - CyGenics acquires stake in DNAPro in exchange for Cell Sciences subsidiary

Multiple Myeloma - Multiple myeloma is linked to differential vascular endothelial growth factor expression

Multiple Sclerosis - Multiple sclerosis T cell repertoire is similar in childhood and adult onset

Multiple Sclerosis - Pregnant multiple sclerosis patients display variations in chemokine receptor