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Ischemia

Myocardial ischemia-reperfusion injury is limited by hydrogen sulfide production

Published in Hematology Week, October 2nd, 2006

The production of hydrogen sulfide limits myocardial ischemia and reperfusion injury and contributes to the cardioprotective effects of preconditioning with endotoxin, but not ischemia, in the rat.

Researchers working in England report, "We investigated whether (endogenous) hydrogen sulfide (H2 S) protects the heart against myocardial ischemia and reperfusion injury. Furthermore, we investigated whether endogenous H2 S is involved in the protection afforded by

(1) ischemic preconditioning and

(2) the second window of protection caused by endotoxin."

"The involvement of one of the potential...

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