Hematology Week
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Acute Lymphoblastic Leukemia Therapy
Reports outline acute lymphoblastic leukemia therapy study results from New York University, Childrens Center for Cancer and Blood Diseases
April 16th, 2007
Investigators publish new data in the report "Diverse pathways mediate chemotherapy-induced cell death in acute lymphoblastic leukemia cell lines. Cancer cell resistance to chemotherapy may be mediated by defects in apoptotic pathways. A prior study showed that in vivo apoptosis of Acute Lymphoblastic Leukemia (ALL) blasts in response to chemotherapy could occur through diverse pathways including both p53-dependent and -independent mechanisms," scientists in the United States report. "In this study we investigated the apoptotic response in more detail by using a panel of ALL cell lines that differed in respect to p53 status. Upon exposure to a uniform stimulus,...
Source: Hematology Week (2007-04-16)
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